ID   PCAI_PSEPU              Reviewed;         231 AA.
AC   Q01103;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 2.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=3-oxoadipate CoA-transferase subunit A;
DE            EC=2.8.3.6;
DE   AltName: Full=Beta-ketoadipate:succinyl-CoA transferase subunit A;
GN   Name=pcaI;
OS   Pseudomonas putida (Arthrobacter siderocapsulatus).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=303;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=PRS2000;
RX   PubMed=1624453; DOI=10.1128/jb.174.14.4657-4666.1992;
RA   Parales R.E., Harwood C.S.;
RT   "Characterization of the genes encoding beta-ketoadipate: succinyl-coenzyme
RT   A transferase in Pseudomonas putida.";
RL   J. Bacteriol. 174:4657-4666(1992).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-6.
RX   PubMed=6780551; DOI=10.1016/s0021-9258(19)69841-8;
RA   Yeh W.-K., Ornston L.N.;
RT   "Evolutionarily homologous alpha 2 beta 2 oligomeric structures in beta-
RT   ketoadipate succinyl-CoA transferases from Acinetobacter calcoaceticus and
RT   Pseudomonas putida.";
RL   J. Biol. Chem. 256:1565-1569(1981).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-oxoadipate + succinyl-CoA = 3-oxoadipyl-CoA + succinate;
CC         Xref=Rhea:RHEA:12048, ChEBI:CHEBI:15775, ChEBI:CHEBI:30031,
CC         ChEBI:CHEBI:57292, ChEBI:CHEBI:57348; EC=2.8.3.6;
CC   -!- PATHWAY: Aromatic compound metabolism; beta-ketoadipate pathway;
CC       acetyl-CoA and succinyl-CoA from 3-oxoadipate: step 1/2.
CC   -!- SUBUNIT: Heterodimer.
CC   -!- SIMILARITY: Belongs to the 3-oxoacid CoA-transferase subunit A family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M88763; AAA25922.1; -; Genomic_DNA.
DR   PIR; A42985; A42985.
DR   AlphaFoldDB; Q01103; -.
DR   SMR; Q01103; -.
DR   BioCyc; MetaCyc:MON-3190; -.
DR   BRENDA; 2.8.3.6; 5092.
DR   UniPathway; UPA00157; UER00262.
DR   GO; GO:0047569; F:3-oxoadipate CoA-transferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0042952; P:beta-ketoadipate pathway; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR012792; 3-oxoacid_CoA-transf_A.
DR   InterPro; IPR004165; CoA_trans_fam_I.
DR   InterPro; IPR004163; CoA_transf_BS.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   PANTHER; PTHR13707; PTHR13707; 1.
DR   Pfam; PF01144; CoA_trans; 1.
DR   SMART; SM00882; CoA_trans; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   TIGRFAMs; TIGR02429; pcaI_scoA_fam; 1.
DR   PROSITE; PS01273; COA_TRANSF_1; 1.
PE   1: Evidence at protein level;
KW   Aromatic hydrocarbons catabolism; Direct protein sequencing; Transferase.
FT   CHAIN           1..231
FT                   /note="3-oxoadipate CoA-transferase subunit A"
FT                   /id="PRO_0000157907"
FT   BINDING         25..31
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   231 AA;  24234 MW;  B5071507AC6A442C CRC64;
     MINKTYESIA SAVEGITDGS TIMVGGFGTA GMPSELIDGL IATGARDLTI ISNNAGNGEI
     GLAALLMAGS VRKVVCSFPR QSDSYVFDEL YRAGKIELEV VPQGNLAERI AAAGSGIGAF
     FSPTGYGTLL AEGKETREID GRMYVLEMPL HADFALIKAH KGDRWGNLTY RKAARNFGPI
     MAMAAKTAIA QVDQVVELGE LDPEHIITPG IFVQRVVAVS GAAASSIAKA I