ID   ASPDH_DANRE             Reviewed;         276 AA.
AC   Q66I59;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Aspartate dehydrogenase domain-containing protein {ECO:0000305};
GN   Name=aspdh; ORFNames=zgc:103722;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the L-aspartate dehydrogenase family.
CC       {ECO:0000305}.
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DR   EMBL; BC081519; AAH81519.1; -; mRNA.
DR   RefSeq; NP_001004657.1; NM_001004657.1.
DR   AlphaFoldDB; Q66I59; -.
DR   SMR; Q66I59; -.
DR   STRING; 7955.ENSDARP00000055854; -.
DR   PaxDb; Q66I59; -.
DR   GeneID; 447919; -.
DR   KEGG; dre:447919; -.
DR   CTD; 554235; -.
DR   ZFIN; ZDB-GENE-040912-102; aspdh.
DR   eggNOG; ENOG502QVGC; Eukaryota.
DR   InParanoid; Q66I59; -.
DR   PhylomeDB; Q66I59; -.
DR   PRO; PR:Q66I59; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0033735; F:aspartate dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009435; P:NAD biosynthetic process; IEA:InterPro.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR002811; Asp_DH.
DR   InterPro; IPR011182; L-Asp_DH.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01958; DUF108; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF005227; Asp_dh_NAD_syn; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..276
FT                   /note="Aspartate dehydrogenase domain-containing protein"
FT                   /id="PRO_0000144903"
SQ   SEQUENCE   276 AA;  29753 MW;  8DEC2D2AEB852CA9 CRC64;
     MADKALKVGI VGYGHLGQFL VEKIQSEGAE VGLQLAFVWN RNADKLKDSL PKDLILHDLS
     DFTQRDTDVI VEVCHPLIVK EFGVRFLSHA HFLVGSPSAL SDGQLEQDLR TAAKQQGKTL
     YVPSGALWGG QDIQKMNDSG TLRALSIRMS KHPSCFRLTG GLLSDWTEGE GRRVLYRGSV
     AELCPLAPNN VNTMAAAAIA ASKLGFHGVT GEIVSDTALA DYHVVEVDVT GPDGFSVKTM
     RQNPAKLGAV TGKATYNSFW SSLLVCKGHG GRVYLC