PCAQ_AGRFC
ID PCAQ_AGRFC Reviewed; 311 AA.
AC P0A4T6; P52668;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=HTH-type transcriptional regulator PcaQ;
DE AltName: Full=Pca operon transcriptional activator;
GN Name=pcaQ; OrderedLocusNames=Atu4543; ORFNames=AGR_L_649;
OS Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens
OS (strain C58)).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium;
OC Agrobacterium tumefaciens complex.
OX NCBI_TaxID=176299;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C58 / ATCC 33970;
RX PubMed=11743193; DOI=10.1126/science.1066804;
RA Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P., Okura V.K.,
RA Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L., Chen Y.,
RA Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr., Chapman P.,
RA Clendenning J., Deatherage G., Gillet W., Grant C., Kutyavin T., Levy R.,
RA Li M.-J., McClelland E., Palmieri A., Raymond C., Rouse G.,
RA Saenphimmachak C., Wu Z., Romero P., Gordon D., Zhang S., Yoo H., Tao Y.,
RA Biddle P., Jung M., Krespan W., Perry M., Gordon-Kamm B., Liao L., Kim S.,
RA Hendrick C., Zhao Z.-Y., Dolan M., Chumley F., Tingey S.V., Tomb J.-F.,
RA Gordon M.P., Olson M.V., Nester E.W.;
RT "The genome of the natural genetic engineer Agrobacterium tumefaciens
RT C58.";
RL Science 294:2317-2323(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C58 / ATCC 33970;
RX PubMed=11743194; DOI=10.1126/science.1066803;
RA Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M., Qurollo B.,
RA Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L., Houmiel K.,
RA Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F., Wollam C., Allinger M.,
RA Doughty D., Scott C., Lappas C., Markelz B., Flanagan C., Crowell C.,
RA Gurson J., Lomo C., Sear C., Strub G., Cielo C., Slater S.;
RT "Genome sequence of the plant pathogen and biotechnology agent
RT Agrobacterium tumefaciens C58.";
RL Science 294:2323-2328(2001).
CC -!- FUNCTION: Activates transcription of the pcaDCHGB operon for the
CC catabolism of the phenolic compound protocatechuate.
CC -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE007870; AAK88900.2; -; Genomic_DNA.
DR PIR; AC3115; AC3115.
DR PIR; B98172; B98172.
DR RefSeq; NP_356115.2; NC_003063.2.
DR RefSeq; WP_010973945.1; NC_003063.2.
DR AlphaFoldDB; P0A4T6; -.
DR SMR; P0A4T6; -.
DR STRING; 176299.Atu4543; -.
DR EnsemblBacteria; AAK88900; AAK88900; Atu4543.
DR KEGG; atu:Atu4543; -.
DR PATRIC; fig|176299.10.peg.4349; -.
DR eggNOG; COG0583; Bacteria.
DR HOGENOM; CLU_039613_6_0_5; -.
DR OMA; HLYSEQV; -.
DR PhylomeDB; P0A4T6; -.
DR BioCyc; AGRO:ATU4543-MON; -.
DR Proteomes; UP000000813; Chromosome linear.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0019619; P:3,4-dihydroxybenzoate catabolic process; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR005119; LysR_subst-bd.
DR InterPro; IPR012787; TF_PcaQ.
DR InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00126; HTH_1; 1.
DR Pfam; PF03466; LysR_substrate; 1.
DR PRINTS; PR00039; HTHLYSR.
DR SUPFAM; SSF46785; SSF46785; 1.
DR TIGRFAMs; TIGR02424; TF_pcaQ; 1.
DR PROSITE; PS50931; HTH_LYSR; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..311
FT /note="HTH-type transcriptional regulator PcaQ"
FT /id="PRO_0000105739"
FT DOMAIN 6..63
FT /note="HTH lysR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT DNA_BIND 23..42
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ SEQUENCE 311 AA; 33546 MW; DCE6C7B6127CE6F6 CRC64;
MVDQRIKFRH LQTFVEVARQ KSVIRAAEIL HVSQPAVTKT IRELEDVLGV SLLEREGRGI
RISRYGEVFL RHAGATMTAL RQAVDSVSQE AARAGPPVRV GALPTVSVRI MPKAMSGFLA
EKTGSPVKIV TGENAVLLEQ LRVGDLDLVV GRLAAPQKMA GFSFEHLYSE KVRFVVRAGH
PLLSPGLSVF DHLHEYPVLM PTRQSVIGPV VEQFLIANGV PALPIRIETV SDAFGRAFLR
TSDAIWIISE GVVAADVADG ILAILPVETG DTSGPVGLTV RADTQPSLPL SLLMQAIREA
AGELFDGRTE G