PCARE_HUMAN
ID PCARE_HUMAN Reviewed; 1288 AA.
AC A6NGG8;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Photoreceptor cilium actin regulator {ECO:0000312|HGNC:HGNC:34383};
GN Name=PCARE {ECO:0000312|HGNC:HGNC:34383}; Synonyms=C2orf71;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1156-1288.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP INVOLVEMENT IN RP54, VARIANT LEU-867, AND TISSUE SPECIFICITY.
RX PubMed=20398884; DOI=10.1016/j.ajhg.2010.03.016;
RA Collin R.W.J., Safieh C., Littink K.W., Shalev S.A., Garzozi H.J.,
RA Rizel L., Abbasi A.H., Cremers F.P.M., den Hollander A.I., Klevering B.J.,
RA Ben-Yosef T.;
RT "Mutations in C2orf71 cause autosomal-recessive retinitis pigmentosa.";
RL Am. J. Hum. Genet. 86:783-788(2010).
RN [4]
RP FUNCTION, VARIANT RP54 PHE-201, INVOLVEMENT IN RP54, AND SUBCELLULAR
RP LOCATION.
RX PubMed=20398886; DOI=10.1016/j.ajhg.2010.03.005;
RA Nishimura D.Y., Baye L.M., Perveen R., Searby C.C., Avila-Fernandez A.,
RA Pereiro I., Ayuso C., Valverde D., Bishop P.N., Manson F.D.C., Urquhart J.,
RA Stone E.M., Slusarski D.C., Black G.C.M., Sheffield V.C.;
RT "Discovery and functional analysis of a retinitis pigmentosa gene,
RT C2orf71.";
RL Am. J. Hum. Genet. 86:686-695(2010).
RN [5]
RP VARIANTS RP54 CYS-320; ASN-372; PRO-612 AND ASP-615, AND VARIANTS CYS-13;
RP LYS-227; ALA-247; ASP-252; ILE-258; ASN-312; LYS-378; ARG-421; MET-580;
RP THR-628; PRO-648; TYR-688; VAL-792; LEU-867; SER-954; GLN-955; THR-959;
RP ARG-1020; PRO-1089 DEL; THR-1160; GLN-1177; SER-1225 INS; SER-1247 AND
RP LEU-1254.
RX PubMed=21412943; DOI=10.1002/humu.21460;
RA Audo I., Lancelot M.E., Mohand-Said S., Antonio A., Germain A., Sahel J.A.,
RA Bhattacharya S.S., Zeitz C.;
RT "Novel C2orf71 mutations account for approximately 1% of cases in a large
RT French arRP cohort.";
RL Hum. Mutat. 32:E2091-E2103(2011).
RN [6]
RP VARIANT ARG-1176.
RX PubMed=28837730; DOI=10.1167/iovs.16-20941;
RA Wang B., Liu Y., Chen S., Wu Y., Lin S., Duan Y., Zheng K., Zhang L.,
RA Gu X., Hong W., Shao H., Zeng X., Sun B., Duan S.;
RT "A novel potentially causative variant of NDUFAF7 revealed by mutation
RT screening in a chinese family with pathologic myopia.";
RL Invest. Ophthalmol. Vis. Sci. 58:4182-4192(2017).
RN [7]
RP VARIANT 1097-GLN--SER-1288 DEL.
RX PubMed=24780881; DOI=10.1136/jmedgenet-2014-102287;
RA Khateb S., Zelinger L., Mizrahi-Meissonnier L., Ayuso C., Koenekoop R.K.,
RA Laxer U., Gross M., Banin E., Sharon D.;
RT "A homozygous nonsense CEP250 mutation combined with a heterozygous
RT nonsense C2orf71 mutation is associated with atypical Usher syndrome.";
RL J. Med. Genet. 51:460-469(2014).
CC -!- FUNCTION: Plays an essential role for normal photoreceptor cell
CC maintenance and vision. {ECO:0000269|PubMed:20398886}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, photoreceptor outer
CC segment {ECO:0000269|PubMed:20398886}. Photoreceptor inner segment
CC {ECO:0000250|UniProtKB:Q6PAC4}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in retina.
CC {ECO:0000269|PubMed:20398884}.
CC -!- DISEASE: Retinitis pigmentosa 54 (RP54) [MIM:613428]: A retinal
CC dystrophy belonging to the group of pigmentary retinopathies. Retinitis
CC pigmentosa is characterized by retinal pigment deposits visible on
CC fundus examination and primary loss of rod photoreceptor cells followed
CC by secondary loss of cone photoreceptors. Patients typically have night
CC vision blindness and loss of midperipheral visual field. As their
CC condition progresses, they lose their far peripheral visual field and
CC eventually central vision as well. {ECO:0000269|PubMed:20398884,
CC ECO:0000269|PubMed:20398886, ECO:0000269|PubMed:21412943}. Note=The
CC disease is caused by variants affecting the gene represented in this
CC entry.
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DR EMBL; AC105398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK092250; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS42669.1; -.
DR RefSeq; NP_001025054.1; NM_001029883.2.
DR PDB; 7LXF; X-ray; 1.65 A; A=813-848.
DR PDBsum; 7LXF; -.
DR AlphaFoldDB; A6NGG8; -.
DR SMR; A6NGG8; -.
DR BioGRID; 132908; 6.
DR IntAct; A6NGG8; 5.
DR STRING; 9606.ENSP00000332809; -.
DR iPTMnet; A6NGG8; -.
DR PhosphoSitePlus; A6NGG8; -.
DR BioMuta; C2orf71; -.
DR EPD; A6NGG8; -.
DR jPOST; A6NGG8; -.
DR MassIVE; A6NGG8; -.
DR PaxDb; A6NGG8; -.
DR PeptideAtlas; A6NGG8; -.
DR PRIDE; A6NGG8; -.
DR ProteomicsDB; 1125; -.
DR Antibodypedia; 62851; 37 antibodies from 12 providers.
DR DNASU; 388939; -.
DR Ensembl; ENST00000331664.6; ENSP00000332809.4; ENSG00000179270.7.
DR GeneID; 388939; -.
DR KEGG; hsa:388939; -.
DR MANE-Select; ENST00000331664.6; ENSP00000332809.4; NM_001029883.3; NP_001025054.1.
DR UCSC; uc002rmt.3; human.
DR CTD; 388939; -.
DR DisGeNET; 388939; -.
DR GeneCards; PCARE; -.
DR GeneReviews; PCARE; -.
DR HGNC; HGNC:34383; PCARE.
DR HPA; ENSG00000179270; Tissue enriched (retina).
DR MalaCards; PCARE; -.
DR MIM; 613425; gene.
DR MIM; 613428; phenotype.
DR neXtProt; NX_A6NGG8; -.
DR OpenTargets; ENSG00000179270; -.
DR Orphanet; 791; Retinitis pigmentosa.
DR PharmGKB; PA162379508; -.
DR VEuPathDB; HostDB:ENSG00000179270; -.
DR eggNOG; ENOG502QUWN; Eukaryota.
DR GeneTree; ENSGT00390000002768; -.
DR HOGENOM; CLU_007417_0_0_1; -.
DR InParanoid; A6NGG8; -.
DR OMA; IMPPRFP; -.
DR OrthoDB; 268004at2759; -.
DR PhylomeDB; A6NGG8; -.
DR TreeFam; TF336604; -.
DR PathwayCommons; A6NGG8; -.
DR SignaLink; A6NGG8; -.
DR BioGRID-ORCS; 388939; 12 hits in 1033 CRISPR screens.
DR GenomeRNAi; 388939; -.
DR Pharos; A6NGG8; Tbio.
DR PRO; PR:A6NGG8; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; A6NGG8; protein.
DR Bgee; ENSG00000179270; Expressed in apex of heart and 55 other tissues.
DR Genevisible; A6NGG8; HS.
DR GO; GO:0005929; C:cilium; IDA:MGI.
DR GO; GO:0120199; C:cone photoreceptor outer segment; IEA:Ensembl.
DR GO; GO:0001917; C:photoreceptor inner segment; IBA:GO_Central.
DR GO; GO:0001750; C:photoreceptor outer segment; IBA:GO_Central.
DR GO; GO:0035845; P:photoreceptor cell outer segment organization; IBA:GO_Central.
DR GO; GO:1903546; P:protein localization to photoreceptor outer segment; IBA:GO_Central.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR InterPro; IPR029352; PCARE.
DR PANTHER; PTHR22017; PTHR22017; 1.
DR Pfam; PF15449; Retinal; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell projection; Ciliopathy; Cilium; Disease variant;
KW Lipoprotein; Myristate; Palmitate; Reference proteome;
KW Retinitis pigmentosa; Sensory transduction; Vision.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000255"
FT CHAIN 2..1288
FT /note="Photoreceptor cilium actin regulator"
FT /id="PRO_0000329078"
FT REGION 78..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 368..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 467..527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 563..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 686..707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 813..1109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1132..1169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1190..1288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..133
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 386..401
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..527
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 584..605
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 845..862
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 890..913
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 925..949
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1023..1039
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1052..1094
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1139..1153
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1207..1226
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1270..1288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000255"
FT LIPID 3
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT VARIANT 13
FT /note="S -> C (in dbSNP:rs10084168)"
FT /evidence="ECO:0000269|PubMed:21412943"
FT /id="VAR_042646"
FT VARIANT 201
FT /note="I -> F (in RP54; induces proteasomal degradation;
FT dbSNP:rs267606690)"
FT /evidence="ECO:0000269|PubMed:20398886"
FT /id="VAR_063395"
FT VARIANT 227
FT /note="E -> K (in dbSNP:rs114057537)"
FT /evidence="ECO:0000269|PubMed:21412943"
FT /id="VAR_065267"
FT VARIANT 247
FT /note="V -> A (in dbSNP:rs77828062)"
FT /evidence="ECO:0000269|PubMed:21412943"
FT /id="VAR_065268"
FT VARIANT 252
FT /note="A -> D (in dbSNP:rs77003681)"
FT /evidence="ECO:0000269|PubMed:21412943"
FT /id="VAR_065269"
FT VARIANT 258
FT /note="R -> I (in dbSNP:rs116156338)"
FT /evidence="ECO:0000269|PubMed:21412943"
FT /id="VAR_065270"
FT VARIANT 312
FT /note="S -> N (in dbSNP:rs1572829341)"
FT /evidence="ECO:0000269|PubMed:21412943"
FT /id="VAR_065271"
FT VARIANT 320
FT /note="R -> C (in RP54; unknown pathological significance;
FT dbSNP:rs374283240)"
FT /evidence="ECO:0000269|PubMed:21412943"
FT /id="VAR_065272"
FT VARIANT 372
FT /note="D -> N (in RP54; dbSNP:rs201284350)"
FT /evidence="ECO:0000269|PubMed:21412943"
FT /id="VAR_065273"
FT VARIANT 378
FT /note="E -> K (in dbSNP:rs201900716)"
FT /evidence="ECO:0000269|PubMed:21412943"
FT /id="VAR_065274"
FT VARIANT 421
FT /note="K -> R (in dbSNP:rs17007544)"
FT /evidence="ECO:0000269|PubMed:21412943"
FT /id="VAR_042647"
FT VARIANT 580
FT /note="T -> M (in dbSNP:rs10166913)"
FT /evidence="ECO:0000269|PubMed:21412943"
FT /id="VAR_042648"
FT VARIANT 612
FT /note="L -> P (in RP54; dbSNP:rs200758183)"
FT /evidence="ECO:0000269|PubMed:21412943"
FT /id="VAR_065275"
FT VARIANT 615
FT /note="V -> D (in RP54; dbSNP:rs140776870)"
FT /evidence="ECO:0000269|PubMed:21412943"
FT /id="VAR_065276"
FT VARIANT 628
FT /note="A -> T (in dbSNP:rs571059484)"
FT /evidence="ECO:0000269|PubMed:21412943"
FT /id="VAR_065277"
FT VARIANT 648
FT /note="A -> P"
FT /evidence="ECO:0000269|PubMed:21412943"
FT /id="VAR_065278"
FT VARIANT 688
FT /note="C -> Y (in dbSNP:rs149601594)"
FT /evidence="ECO:0000269|PubMed:21412943"
FT /id="VAR_065279"
FT VARIANT 792
FT /note="L -> V (in dbSNP:rs17744093)"
FT /evidence="ECO:0000269|PubMed:21412943"
FT /id="VAR_042649"
FT VARIANT 867
FT /note="P -> L (in dbSNP:rs182248363)"
FT /evidence="ECO:0000269|PubMed:20398884,
FT ECO:0000269|PubMed:21412943"
FT /id="VAR_063396"
FT VARIANT 954
FT /note="P -> S (in dbSNP:rs758883789)"
FT /evidence="ECO:0000269|PubMed:21412943"
FT /id="VAR_065280"
FT VARIANT 955
FT /note="R -> Q (in dbSNP:rs184249075)"
FT /evidence="ECO:0000269|PubMed:21412943"
FT /id="VAR_065281"
FT VARIANT 959
FT /note="A -> T (in dbSNP:rs192350796)"
FT /evidence="ECO:0000269|PubMed:21412943"
FT /id="VAR_065282"
FT VARIANT 1020
FT /note="Q -> R (in dbSNP:rs200367963)"
FT /evidence="ECO:0000269|PubMed:21412943"
FT /id="VAR_065283"
FT VARIANT 1089
FT /note="Missing"
FT /evidence="ECO:0000269|PubMed:21412943"
FT /id="VAR_065284"
FT VARIANT 1097..1288
FT /note="Missing (probable disease-associated variant found
FT in a family with sensorineural hearing loss and retinal
FT degeneration; the retinal involvement is more severe in
FT double homozygotes also carrying a CEP250 truncating
FT variant)"
FT /evidence="ECO:0000269|PubMed:24780881"
FT /id="VAR_081751"
FT VARIANT 1160
FT /note="A -> T (in dbSNP:rs766723736)"
FT /evidence="ECO:0000269|PubMed:21412943"
FT /id="VAR_065285"
FT VARIANT 1176
FT /note="Q -> R (found in patients with pathologic myopia;
FT unknown pathological significance; dbSNP:rs182812191)"
FT /evidence="ECO:0000269|PubMed:28837730"
FT /id="VAR_079609"
FT VARIANT 1177
FT /note="R -> Q (in dbSNP:rs375826049)"
FT /evidence="ECO:0000269|PubMed:21412943"
FT /id="VAR_065286"
FT VARIANT 1225
FT /note="S -> SS"
FT /evidence="ECO:0000269|PubMed:21412943"
FT /id="VAR_065287"
FT VARIANT 1247
FT /note="G -> S (in dbSNP:rs187333111)"
FT /evidence="ECO:0000269|PubMed:21412943"
FT /id="VAR_065288"
FT VARIANT 1254
FT /note="P -> L (in dbSNP:rs1975713)"
FT /evidence="ECO:0000269|PubMed:21412943"
FT /id="VAR_042650"
FT HELIX 835..838
FT /evidence="ECO:0007829|PDB:7LXF"
FT HELIX 842..845
FT /evidence="ECO:0007829|PDB:7LXF"
SQ SEQUENCE 1288 AA; 139655 MW; 97AC10B7AB0ED158 CRC64;
MGCTPSHSDL VNSVAKSGIQ FLKKPKAIRP GCQGGSERGS IPLLVKNSTC YDAGEGLAEE
QPSPRRNQTT AKGLCQLMGD PASGKRKDME GLIPGTKTSS SQLNKSQSHM AKDIPFKTQG
SHGSQGADFS GDESEESSTQ DTSKWKRTAK CHTSSTQSHC YQTIHPAHEP EGKVDFPEPL
VKAHQQAYTY LHSSLSKYEA ILCIIHQATQ TRELLQPMVS FLLLCFEEIS QLLGEISKDG
EVLLQEVRED LAWPLKKREP QEQPNLLQQL LQYTVSKLQV LNGTVASLTG SFLEGSSSYL
HSTATHLENK LSTKRNVDER LLRALRQLES LASGCGDPGV QGLPLCSEDS GIGADNESVQ
SVDKLGKQTS WDLAPEPEEW KSVTSPHTEA RQSGHTWQQS PFCLGSGRPQ DCLLSGAPMA
KVQPRAQDEA RSPCLSSTSP ENITSPPLKL GTSTPCDSFG IGVSVEPHLS KTSRPMDASS
LSDSEDSSPE EEEEDKMSSM SLCAWQEKTP HSRPQSSPAD RESPFQARTR RLRSLQAQEM
ILKMKESISE RIKFVPVPCG HQDWSEEEEG RTVVPPRPST VSGSRRAPER QTRSQSESCL
QSHVEDPTFQ ELRRVQRDLS QKLEAFYALG AKGQGQSQEQ ILQPRAAAVW PNGTCRVSPS
NTTSRLKASL TKNFSILPSQ DKSILQKCNP HPEDEQGKAG KLPNAIPSGE VSEAAKATDW
NVRGCPTRTS VKKLIETFSP TESLRMLGDS KDAGASPCLR NCIMPPRFPK YTGLAPLYPK
PQISPASGRE SLKMGIGWKP LAPIFPPLPK AEAAKSEELS CEMEGNLEHL PPPPMEVLMD
KSFASLESPE SSKSTENSPK ETQEPGPGEA GPTRRTWASP KLRASVSPLD LLPSKSTASL
TKPHSTGPGS GRSSCQPRKP ALDLSSPPAT SQSPEVKGGT WSQAEKATSL YRQPRKAIAW
HHSGPPSGQN RTSESSLARP RQSRERSPPV GRKASPTRTH WVPQADKRRR SLPSSYRPAQ
PSPSAVQTPP SPPVSPRVLS PPTTKRRTSP PHQPKLPNPP PESAPAQCKV PSPPTQHPEA
SPPFSIPSPS PPMSPSQEHK ETRDSEDSQA VIAKVSGNTH SIFCPATSSL FEAKPPLSTA
HPLTPPSLPP EAGGPLGNPA ECWKNSSGPW LRADSQRRAA LCALNPLPFL RRTASDRQPG
GRPQPPTLDP TSTSYESQLG QNSSSEESPK KDTEPGSSPC SPELQGGTRR ASPPEFCVLG
HGLQPEPRTG HIQDKSQPEA QPQQEEVS
