ID   PCAR_PSEPU              Reviewed;         291 AA.
AC   Q52154;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Pca regulon regulatory protein;
GN   Name=pcaR;
OS   Pseudomonas putida (Arthrobacter siderocapsulatus).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=303;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=PRS2000;
RX   PubMed=8083169; DOI=10.1128/jb.176.18.5771-5779.1994;
RA   Romero-Steiner S., Parales R.E., Harwood C.S., Houghton J.E.;
RT   "Characterization of the pcaR regulatory gene from Pseudomonas putida,
RT   which is required for the complete degradation of p-hydroxybenzoate.";
RL   J. Bacteriol. 176:5771-5779(1994).
CC   -!- FUNCTION: Positive regulator of all genes within the pca regulon,
CC       pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to
CC       aromatic compounds.
CC   -!- INDUCTION: By beta-ketoadipate.
CC   -!- CAUTION: It is uncertain whether Met-1, Met-23 or Met-45 is the
CC       initiator. {ECO:0000305}.
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DR   EMBL; L33795; AAA57136.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q52154; -.
DR   SMR; Q52154; -.
DR   STRING; 1240350.AMZE01000001_gene2836; -.
DR   eggNOG; COG1414; Bacteria.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046278; P:3,4-dihydroxybenzoate metabolic process; IEA:InterPro.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR012794; PcaR_PcaU.
DR   InterPro; IPR014757; Tscrpt_reg_IclR_C.
DR   InterPro; IPR005471; Tscrpt_reg_IclR_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF09339; HTH_IclR; 1.
DR   Pfam; PF01614; IclR; 1.
DR   SMART; SM00346; HTH_ICLR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR02431; pcaR_pcaU; 1.
DR   PROSITE; PS51077; HTH_ICLR; 1.
DR   PROSITE; PS51078; ICLR_ED; 1.
PE   2: Evidence at transcript level;
KW   Activator; Aromatic hydrocarbons catabolism; DNA-binding; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..291
FT                   /note="Pca regulon regulatory protein"
FT                   /id="PRO_0000201764"
FT   DOMAIN          45..105
FT                   /note="HTH iclR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
FT   DOMAIN          120..291
FT                   /note="IclR-ED"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00394"
FT   DNA_BIND        67..86
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   291 AA;  31811 MW;  BA6F384876935F6B CRC64;
     MSDETLVNDP VNPEPARPAS AAMAPPIVAS PAKRIQAFTG DPDFMTSLAR GLAVIQAFQE
     RKRHLTIAQI SHRTEIPRAA VRRCLHTLIK LGYATSDGRT YSLLPKVLTL GHAYLSSTPL
     AISAQPYLDR ISDQLHEAAN MATLEGDDIL YIARSATVER LISVDLSVGG RLPAYCTSMG
     RILLAAMDDT SLREYLGRAD LKARTSRTLH DPESLFACIQ QVRAQGWCVV DQELEQGLRS
     IAVPIYDASG QVLAALNVST HVGRVTRSEL EQRFLPILLA ASRDLCHQLF G