PCAU_ACIAD
ID PCAU_ACIAD Reviewed; 278 AA.
AC O83046; Q43939;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Pca operon regulatory protein;
GN Name=pcaU; OrderedLocusNames=ACIAD1702;
OS Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter.
OX NCBI_TaxID=62977;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9515921; DOI=10.1128/jb.180.6.1512-1524.1998;
RA Gerischer U., Segura A., Ornston L.N.;
RT "PcaU, a transcriptional activator of genes for protocatechuate utilization
RT in Acinetobacter.";
RL J. Bacteriol. 180:1512-1524(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33305 / BD413 / ADP1;
RX PubMed=15514110; DOI=10.1093/nar/gkh910;
RA Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L.,
RA Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N.,
RA Weissenbach J., Marliere P., Cohen G.N., Medigue C.;
RT "Unique features revealed by the genome sequence of Acinetobacter sp. ADP1,
RT a versatile and naturally transformation competent bacterium.";
RL Nucleic Acids Res. 32:5766-5779(2004).
CC -!- FUNCTION: Activates transcription of the pca operon.
CC -!- INDUCTION: By protocatechuate.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-5 is the initiator.
CC {ECO:0000305}.
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DR EMBL; L05770; AAC37157.1; -; Genomic_DNA.
DR EMBL; CR543861; CAG68545.1; -; Genomic_DNA.
DR AlphaFoldDB; O83046; -.
DR SMR; O83046; -.
DR STRING; 62977.ACIAD1702; -.
DR PRIDE; O83046; -.
DR EnsemblBacteria; CAG68545; CAG68545; ACIAD1702.
DR KEGG; aci:ACIAD1702; -.
DR eggNOG; COG1414; Bacteria.
DR HOGENOM; CLU_062618_0_1_6; -.
DR OMA; HTHKIMS; -.
DR Proteomes; UP000000430; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046278; P:3,4-dihydroxybenzoate metabolic process; IEA:InterPro.
DR GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR012794; PcaR_PcaU.
DR InterPro; IPR014757; Tscrpt_reg_IclR_C.
DR InterPro; IPR005471; Tscrpt_reg_IclR_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF09339; HTH_IclR; 1.
DR Pfam; PF01614; IclR; 1.
DR SMART; SM00346; HTH_ICLR; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR TIGRFAMs; TIGR02431; pcaR_pcaU; 1.
DR PROSITE; PS51077; HTH_ICLR; 1.
DR PROSITE; PS51078; ICLR_ED; 1.
PE 2: Evidence at transcript level;
KW Activator; Aromatic hydrocarbons catabolism; DNA-binding;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..278
FT /note="Pca operon regulatory protein"
FT /id="PRO_0000201765"
FT DOMAIN 31..91
FT /note="HTH iclR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
FT DOMAIN 106..278
FT /note="IclR-ED"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00394"
FT DNA_BIND 53..72
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
SQ SEQUENCE 278 AA; 31595 MW; FF63F12044FB4B93 CRC64;
MWSNMDDKKV KEEKILHNST NKKIIRHEDF VAGISKGMAI LDSFGTDRHR LNITMAAEKT
GMTRAAARRH LLTLEYLGYL ESDGHYFYLT PKILKFSGSY LGGAQLPKIS QPLLNLLTTQ
TSLIYSVMVL DGYEAITIAR SAAHQQTDRV NPYGLHLGNR LPAHATSAGK ILLAYLDDHA
QQEWLNQYPL QRLTKYTYTN NIDFLRLLSE IKEQGWCYSS EEHELGVHAL AVPIYGQQSR
VVAALNIVSP TMRTTKEYLI QHILPLLQET ARELRNIL
