ASPDH_MOUSE
ID ASPDH_MOUSE Reviewed; 287 AA.
AC Q9DCQ2; Q8VCQ0;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Aspartate dehydrogenase domain-containing protein {ECO:0000305};
GN Name=Aspdh {ECO:0000312|MGI:MGI:1915602};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PROTEIN SEQUENCE OF 13-20, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=OF1; TISSUE=Hippocampus;
RA Lubec G., Sunyer B., Chen W.-Q.;
RL Submitted (JAN-2009) to UniProtKB.
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, and Liver;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the L-aspartate dehydrogenase family.
CC {ECO:0000305}.
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DR EMBL; AK002587; BAB22209.1; -; mRNA.
DR EMBL; BC019451; AAH19451.1; -; mRNA.
DR CCDS; CCDS21207.1; -.
DR RefSeq; NP_080966.1; NM_026690.1.
DR AlphaFoldDB; Q9DCQ2; -.
DR SMR; Q9DCQ2; -.
DR STRING; 10090.ENSMUSP00000039202; -.
DR iPTMnet; Q9DCQ2; -.
DR PhosphoSitePlus; Q9DCQ2; -.
DR jPOST; Q9DCQ2; -.
DR MaxQB; Q9DCQ2; -.
DR PaxDb; Q9DCQ2; -.
DR PeptideAtlas; Q9DCQ2; -.
DR PRIDE; Q9DCQ2; -.
DR ProteomicsDB; 277046; -.
DR Antibodypedia; 46022; 77 antibodies from 12 providers.
DR Ensembl; ENSMUST00000035929; ENSMUSP00000039202; ENSMUSG00000038704.
DR GeneID; 68352; -.
DR KEGG; mmu:68352; -.
DR UCSC; uc009gpk.1; mouse.
DR CTD; 554235; -.
DR MGI; MGI:1915602; Aspdh.
DR VEuPathDB; HostDB:ENSMUSG00000038704; -.
DR eggNOG; ENOG502QVGC; Eukaryota.
DR GeneTree; ENSGT00390000004452; -.
DR InParanoid; Q9DCQ2; -.
DR OMA; HIVEVDV; -.
DR OrthoDB; 1182611at2759; -.
DR PhylomeDB; Q9DCQ2; -.
DR TreeFam; TF315092; -.
DR BioGRID-ORCS; 68352; 4 hits in 71 CRISPR screens.
DR PRO; PR:Q9DCQ2; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q9DCQ2; protein.
DR Bgee; ENSMUSG00000038704; Expressed in right kidney and 33 other tissues.
DR ExpressionAtlas; Q9DCQ2; baseline and differential.
DR Genevisible; Q9DCQ2; MM.
DR GO; GO:0033735; F:aspartate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0009435; P:NAD biosynthetic process; IEA:InterPro.
DR InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR InterPro; IPR002811; Asp_DH.
DR InterPro; IPR011182; L-Asp_DH.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR Pfam; PF01958; DUF108; 1.
DR Pfam; PF03447; NAD_binding_3; 1.
DR PIRSF; PIRSF005227; Asp_dh_NAD_syn; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Phosphoprotein; Reference proteome.
FT CHAIN 1..287
FT /note="Aspartate dehydrogenase domain-containing protein"
FT /id="PRO_0000144901"
FT MOD_RES 24
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A6ND91"
FT MOD_RES 172
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A6ND91"
FT CONFLICT 117
FT /note="A -> V (in Ref. 2; AAH19451)"
FT /evidence="ECO:0000305"
FT CONFLICT 245
FT /note="A -> S (in Ref. 2; AAH19451)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 287 AA; 30270 MW; 889D164D943B88DD CRC64;
MATSTLPQVP YKVGVVGYGR LGQSLVSRLL AQGSELGLEL VFVWNRDPGR MAGSVPPALQ
LQDLTALEER HPDLVVEVAH PKIIHESGAQ ILRHANLLVG SPSALADQTT EQQLLEASKR
WGHTVFVARG ALWGSEDISR LDAAGGLQSL RVTMATHPDG FRLEGPLAAA HSSGPRTVLY
EGPVRGLCPL APRNSNTMAA AALAAPSLGF DRVIGVLVAD LSLTDMHVVD VELLGPPGPS
GRSFAVHTHR ENPAQPGAVT GSATVTAFWH SLLGCCQLTS RPGIHLC
