ID   PCBP4_BOVIN             Reviewed;         403 AA.
AC   Q0VCU0;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Poly(rC)-binding protein 4;
DE   AltName: Full=Alpha-CP4;
GN   Name=PCBP4;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal pons;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Single-stranded nucleic acid binding protein that binds
CC       preferentially to oligo dC. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; BC120009; AAI20010.1; -; mRNA.
DR   RefSeq; NP_001068751.1; NM_001075283.2.
DR   RefSeq; XP_010815992.1; XM_010817690.2.
DR   AlphaFoldDB; Q0VCU0; -.
DR   SMR; Q0VCU0; -.
DR   STRING; 9913.ENSBTAP00000024779; -.
DR   PaxDb; Q0VCU0; -.
DR   PRIDE; Q0VCU0; -.
DR   Ensembl; ENSBTAT00000024779; ENSBTAP00000024779; ENSBTAG00000018622.
DR   GeneID; 506889; -.
DR   KEGG; bta:506889; -.
DR   CTD; 57060; -.
DR   VEuPathDB; HostDB:ENSBTAG00000018622; -.
DR   eggNOG; KOG2190; Eukaryota.
DR   GeneTree; ENSGT00940000159711; -.
DR   HOGENOM; CLU_022670_0_0_1; -.
DR   InParanoid; Q0VCU0; -.
DR   OMA; GKAGHRI; -.
DR   OrthoDB; 954970at2759; -.
DR   TreeFam; TF318292; -.
DR   Proteomes; UP000009136; Chromosome 22.
DR   Bgee; ENSBTAG00000018622; Expressed in retina and 106 other tissues.
DR   ExpressionAtlas; Q0VCU0; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003730; F:mRNA 3'-UTR binding; IEA:Ensembl.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0048025; P:negative regulation of mRNA splicing, via spliceosome; IBA:GO_Central.
DR   GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR   GO; GO:0043488; P:regulation of mRNA stability; IEA:Ensembl.
DR   GO; GO:0051252; P:regulation of RNA metabolic process; IBA:GO_Central.
DR   Gene3D; 3.30.1370.10; -; 3.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR004088; KH_dom_type_1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR033088; PCBP4.
DR   PANTHER; PTHR10288:SF166; PTHR10288:SF166; 1.
DR   Pfam; PF00013; KH_1; 3.
DR   SMART; SM00322; KH; 3.
DR   SUPFAM; SSF54791; SSF54791; 3.
DR   PROSITE; PS50084; KH_TYPE_1; 3.
PE   2: Evidence at transcript level;
KW   Cytoplasm; DNA-binding; Reference proteome; Repeat; Ribonucleoprotein;
KW   RNA-binding.
FT   CHAIN           1..403
FT                   /note="Poly(rC)-binding protein 4"
FT                   /id="PRO_0000263084"
FT   DOMAIN          17..67
FT                   /note="KH 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT   DOMAIN          101..154
FT                   /note="KH 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT   DOMAIN          241..293
FT                   /note="KH 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
SQ   SEQUENCE   403 AA;  41542 MW;  74FCB5CFC7A298E9 CRC64;
     MSGSDAGLEE EPELSITLTL RMLMHGKEVG SIIGKKGETV KRIREQSSAR ITISEGSCPE
     RITTITGSTA AVFHAVSMIA FKLDEDLCAA PANGGNVSRP PVTLRLVIPA SQCGSLIGKA
     GTKIKEIRET TGAQVQVAGD LLPNSTERAV TVSGVPDAII LCVRQICAVI LESPPKGATI
     PYHPSLSLGT VLLSTNQGFS VQGQYGTVTP AEVTKLQQLS GHAVPFASPS MVPGLDPSTQ
     TSSQEFLVPN DLIGCVIGRQ GSKISEIRQM SGAHIKIGNQ AEGAGERHVT ITGSPVSIAL
     AQYLITACLE TAKSTSGGTP GSAPTDLPAP FSPPLTALPT APPGLLGTPY AISLSNFIGL
     KPVPFLALPP ASPGPPPGLA AYTAKMAAAN GSKKAERQKF SPY