PCC1_ASHGO
ID PCC1_ASHGO Reviewed; 81 AA.
AC Q753M3;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=EKC/KEOPS complex subunit PCC1;
GN Name=PCC1; OrderedLocusNames=AFR289W;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Component of the EKC/KEOPS complex that is required for the
CC formation of a threonylcarbamoyl group on adenosine at position 37
CC (t(6)A37) in tRNAs that read codons beginning with adenine. The complex
CC is probably involved in the transfer of the threonylcarbamoyl moiety of
CC threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. PCC1 functions
CC as a dimerization module for the complex. The EKC/KEOPS complex also
CC promotes both telomere uncapping and telomere elongation. The complex
CC is required for efficient recruitment of transcriptional coactivators
CC (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the EKC/KEOPS complex composed of at least BUD32,
CC CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, telomere
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CTAG/PCC1 family. {ECO:0000305}.
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DR EMBL; AE016819; AAS53660.1; -; Genomic_DNA.
DR RefSeq; NP_985836.1; NM_211191.1.
DR AlphaFoldDB; Q753M3; -.
DR SMR; Q753M3; -.
DR STRING; 33169.AAS53660; -.
DR EnsemblFungi; AAS53660; AAS53660; AGOS_AFR289W.
DR GeneID; 4622099; -.
DR KEGG; ago:AGOS_AFR289W; -.
DR eggNOG; ENOG502S7CS; Eukaryota.
DR HOGENOM; CLU_113770_5_0_1; -.
DR InParanoid; Q753M3; -.
DR Proteomes; UP000000591; Chromosome VI.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0000408; C:EKC/KEOPS complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0070525; P:tRNA threonylcarbamoyladenosine metabolic process; IBA:GO_Central.
DR InterPro; IPR015419; CTAG/Pcc1.
DR PANTHER; PTHR31283; PTHR31283; 1.
DR Pfam; PF09341; Pcc1; 1.
PE 3: Inferred from homology;
KW Activator; Chromosome; Nucleus; Reference proteome; Telomere;
KW Transcription; Transcription regulation; tRNA processing.
FT CHAIN 1..81
FT /note="EKC/KEOPS complex subunit PCC1"
FT /id="PRO_0000278942"
SQ SEQUENCE 81 AA; 8768 MW; CE85B773158BBECC CRC64;
MDHTLHLHVP FESARLADIA ARALAPDPLL RPEELSVSFA SDGASLNIKL AAIDARVLRV
ATNSIFEALK TVVETADELD F
