ID   PCC1_DEBHA              Reviewed;         100 AA.
AC   Q6BNU4;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=EKC/KEOPS complex subunit PCC1;
GN   Name=PCC1; OrderedLocusNames=DEHA2E18964g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the EKC/KEOPS complex that is required for the
CC       formation of a threonylcarbamoyl group on adenosine at position 37
CC       (t(6)A37) in tRNAs that read codons beginning with adenine. The complex
CC       is probably involved in the transfer of the threonylcarbamoyl moiety of
CC       threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. PCC1 functions
CC       as a dimerization module for the complex. The EKC/KEOPS complex also
CC       promotes both telomere uncapping and telomere elongation. The complex
CC       is required for efficient recruitment of transcriptional coactivators
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the EKC/KEOPS complex composed of at least BUD32,
CC       CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, telomere
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CTAG/PCC1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR382137; CAG88396.2; -; Genomic_DNA.
DR   RefSeq; XP_460126.2; XM_460126.1.
DR   AlphaFoldDB; Q6BNU4; -.
DR   SMR; Q6BNU4; -.
DR   STRING; 4959.XP_460126.2; -.
DR   EnsemblFungi; CAG88396; CAG88396; DEHA2E18964g.
DR   GeneID; 2901900; -.
DR   KEGG; dha:DEHA2E18964g; -.
DR   VEuPathDB; FungiDB:DEHA2E18964g; -.
DR   eggNOG; ENOG502S7CS; Eukaryota.
DR   HOGENOM; CLU_113770_5_0_1; -.
DR   InParanoid; Q6BNU4; -.
DR   OMA; KTIIECM; -.
DR   OrthoDB; 1584653at2759; -.
DR   Proteomes; UP000000599; Chromosome E.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR015419; CTAG/Pcc1.
DR   PANTHER; PTHR31283; PTHR31283; 1.
DR   Pfam; PF09341; Pcc1; 1.
PE   3: Inferred from homology;
KW   Activator; Chromosome; Nucleus; Reference proteome; Telomere;
KW   Transcription; Transcription regulation; tRNA processing.
FT   CHAIN           1..100
FT                   /note="EKC/KEOPS complex subunit PCC1"
FT                   /id="PRO_0000278943"
SQ   SEQUENCE   100 AA;  11088 MW;  DE3899945FF5B4C8 CRC64;
     MTTQTITDEK LSHQVSINIP FESEKQASIA CNSLSPDLIL RSTELSVSCR SSDRNLICEF
     SGSSDRVIRV AISSVIDNLK TIIECMDEFD AKEDVIFTEA