ID   PCC1_PYRAB              Reviewed;          82 AA.
AC   Q9V1Z9; G8ZHQ9;
DT   01-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2014, sequence version 2.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=KEOPS complex subunit Pcc1;
GN   Name=pcc1; OrderedLocusNames=PYRAB02750, PAB3073;
OS   Pyrococcus abyssi (strain GE5 / Orsay).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=272844;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GE5 / Orsay;
RX   PubMed=12622808; DOI=10.1046/j.1365-2958.2003.03381.x;
RA   Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O.,
RA   Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J.,
RA   Weissenbach J., Zivanovic Y., Forterre P.;
RT   "An integrated analysis of the genome of the hyperthermophilic archaeon
RT   Pyrococcus abyssi.";
RL   Mol. Microbiol. 47:1495-1512(2003).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=GE5 / Orsay;
RX   PubMed=22057919; DOI=10.1007/s00284-011-0035-x;
RA   Gao J., Wang J.;
RT   "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and
RT   Pyrococcus furiosus DSM 3638.";
RL   Curr. Microbiol. 64:118-129(2012).
RN   [3]
RP   FUNCTION IN T(6)A TRNA MODIFICATION, AND SUBUNIT.
RX   PubMed=23258706; DOI=10.1093/nar/gks1287;
RA   Perrochia L., Crozat E., Hecker A., Zhang W., Bareille J., Collinet B.,
RA   van Tilbeurgh H., Forterre P., Basta T.;
RT   "In vitro biosynthesis of a universal t6A tRNA modification in Archaea and
RT   Eukarya.";
RL   Nucleic Acids Res. 41:1953-1964(2013).
RN   [4]
RP   FUNCTION IN THE KEOPS COMPLEX, AND SUBUNIT.
RX   PubMed=23945934; DOI=10.1093/nar/gkt720;
RA   Perrochia L., Guetta D., Hecker A., Forterre P., Basta T.;
RT   "Functional assignment of KEOPS/EKC complex subunits in the biosynthesis of
RT   the universal t6A tRNA modification.";
RL   Nucleic Acids Res. 41:9484-9499(2013).
CC   -!- FUNCTION: Component of the KEOPS complex that is required for the
CC       formation of a threonylcarbamoyl group on adenosine at position 37
CC       (t(6)A37) in tRNAs that read codons beginning with adenine. The complex
CC       is probably involved in the transfer of the threonylcarbamoyl moiety of
CC       threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Pcc1 functions
CC       as a dimerization module for the complex. {ECO:0000269|PubMed:23258706,
CC       ECO:0000269|PubMed:23945934}.
CC   -!- SUBUNIT: Component of the KEOPS complex that consists of Kae1, Bud32,
CC       Cgi121 and Pcc1; the whole complex dimerizes.
CC       {ECO:0000269|PubMed:23258706, ECO:0000269|PubMed:23945934}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CTAG/PCC1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAB49199.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AJ248283; CAB49199.1; ALT_INIT; Genomic_DNA.
DR   EMBL; HE613800; CCE69652.1; -; Genomic_DNA.
DR   PIR; H75218; H75218.
DR   RefSeq; WP_048146522.1; NC_000868.1.
DR   PDB; 7A67; X-ray; 3.18 A; A=1-82.
DR   PDBsum; 7A67; -.
DR   AlphaFoldDB; Q9V1Z9; -.
DR   SMR; Q9V1Z9; -.
DR   STRING; 272844.PAB3073; -.
DR   EnsemblBacteria; CAB49199; CAB49199; PAB3073.
DR   GeneID; 1495165; -.
DR   KEGG; pab:PAB3073; -.
DR   PATRIC; fig|272844.11.peg.295; -.
DR   eggNOG; arCOG04414; Archaea.
DR   HOGENOM; CLU_170076_0_1_2; -.
DR   OrthoDB; 131677at2157; -.
DR   Proteomes; UP000000810; Chromosome.
DR   Proteomes; UP000009139; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000408; C:EKC/KEOPS complex; IDA:UniProtKB.
DR   GO; GO:0002949; P:tRNA threonylcarbamoyladenosine modification; IDA:UniProtKB.
DR   InterPro; IPR015419; CTAG/Pcc1.
DR   Pfam; PF09341; Pcc1; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; tRNA processing.
FT   CHAIN           1..82
FT                   /note="KEOPS complex subunit Pcc1"
FT                   /id="PRO_0000430324"
SQ   SEQUENCE   82 AA;  9565 MW;  7768068262DAA939 CRC64;
     MKPKRVQGKI VIEFPSEDIA EVVYTSVLYE HVSVPYRRSR VNFRREGRRI VLEIEANDSS
     AMRGTVNSYL RWIKVALDVL NI