ID   PCCR_CERS4              Reviewed;         461 AA.
AC   Q3J4E6;
DT   11-NOV-2015, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Propionyl-CoA carboxylase regulator {ECO:0000303|PubMed:26170412};
GN   Name=pccR {ECO:0000303|PubMed:26170412};
GN   OrderedLocusNames=RHOS4_07700 {ECO:0000305};
GN   ORFNames=RSP_2186 {ECO:0000312|EMBL:ABA78338.1};
OS   Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG
OS   31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (Rhodobacter
OS   sphaeroides).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Cereibacter.
OX   NCBI_TaxID=272943;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203
RC   / NCIMB 8253 / ATH 2.4.1.;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C.,
RA   Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.;
RT   "Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION AS A REGULATOR, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203
RC   / NCIMB 8253 / ATH 2.4.1.;
RX   PubMed=26170412; DOI=10.1128/jb.00402-15;
RA   Carter M.S., Alber B.E.;
RT   "Transcriptional regulation by the short-chain fatty acyl coenzyme A
RT   regulator (ScfR) PccR controls propionyl coenzyme A assimilation by
RT   Rhodobacter sphaeroides.";
RL   J. Bacteriol. 197:3048-3056(2015).
CC   -!- FUNCTION: Transcriptional regulator that controls propionyl-CoA
CC       assimilation through the methylmalonyl-CoA pathway via regulation of
CC       pccB expression. {ECO:0000269|PubMed:26170412}.
CC   -!- DISRUPTION PHENOTYPE: Mutant is unable to grow with propionate-
CC       HCO(3)(-) as the carbon source. However, the mutant can grow normally
CC       with succinate or acetate as the carbon source.
CC       {ECO:0000269|PubMed:26170412}.
CC   -!- SIMILARITY: Belongs to the short-chain fatty acyl-CoA assimilation
CC       regulator (ScfR) family. {ECO:0000305|PubMed:26170412}.
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DR   EMBL; CP000143; ABA78338.1; -; Genomic_DNA.
DR   RefSeq; WP_002719339.1; NZ_CP030271.1.
DR   RefSeq; YP_352239.1; NC_007493.2.
DR   AlphaFoldDB; Q3J4E6; -.
DR   SMR; Q3J4E6; -.
DR   STRING; 272943.RSP_2186; -.
DR   EnsemblBacteria; ABA78338; ABA78338; RSP_2186.
DR   GeneID; 57469540; -.
DR   GeneID; 67445955; -.
DR   KEGG; rsp:RSP_2186; -.
DR   PATRIC; fig|272943.9.peg.1082; -.
DR   eggNOG; COG1396; Bacteria.
DR   eggNOG; COG3800; Bacteria.
DR   OMA; QRAFPPI; -.
DR   PhylomeDB; Q3J4E6; -.
DR   Proteomes; UP000002703; Chromosome 1.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00093; HTH_XRE; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR001387; Cro/C1-type_HTH.
DR   InterPro; IPR026281; HTH_RamB.
DR   InterPro; IPR010359; IrrE_HExxH.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR018653; ScfR_C.
DR   Pfam; PF01381; HTH_3; 1.
DR   Pfam; PF06114; Peptidase_M78; 1.
DR   Pfam; PF09856; ScfRs; 1.
DR   PIRSF; PIRSF019251; Rv0465c; 1.
DR   SMART; SM00530; HTH_XRE; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   PROSITE; PS50943; HTH_CROC1; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..461
FT                   /note="Propionyl-CoA carboxylase regulator"
FT                   /id="PRO_0000434653"
FT   DOMAIN          11..65
FT                   /note="HTH cro/C1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
FT   DNA_BIND        22..41
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
SQ   SEQUENCE   461 AA;  51311 MW;  44135A624A68B365 CRC64;
     MAQKLYAGAK LRELRVKLGL TQKVFAERLG ASLPYLNQME NNHRPVSATV VLALAQEFGV
     DVTKLTTSEA ERIVTDMREA LADPVFTDSP PLADLRLVAS NAPAFARAFL DLHRAYRQTH
     ERLASLDEAL GRDEADLRPS PWEEVRDFFH YCDNYLDAVD RAAEHYAAPG GVRRDVFSAA
     METLTRAGLD LQISDMPAIR SREGNALRLS ARAAAPTQRF QLLHQVALLT QNDLLEATLD
     LARFQTAEAR EIAKIGLANY FAGAALLPYR PFLQAAAETR HDLERLADLF GASIEQVAHR
     LSTLQRPGAK GVPFFFVRVD QAGTITKRHS ATRFQFARFG GACPLWNVHR AFETPGRFLR
     QLAQTPDGVR YLLLARDVSK PGGSFTAPVR RYAIGLGCEV QHADALVYAD GLDLKGSFEP
     IGISCRICDR QECHQRSVPP LEKRLRVDPD RRGLLPYEIV D