PCD15_CHICK
ID PCD15_CHICK Reviewed; 1899 AA.
AC Q0ZM14; F1N8B3; Q0ZM04; Q0ZM05; Q0ZM06; Q0ZM07; Q0ZM08; Q0ZM09; Q0ZM10;
AC Q0ZM11; Q0ZM12; Q0ZM13;
DT 24-JUL-2013, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2006, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Protocadherin-15;
DE Flags: Precursor;
GN Name=Pcdh15;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4; 5; 6; 7; 8; 9; 10 AND 11),
RP PROTEIN SEQUENCE OF 37-51; 64-93; 228-237; 462-471; 631-643; 858-878;
RP 918-928; 992-1016; 1220-1230; 1265-1292 AND 1599-1608, AND TISSUE
RP SPECIFICITY.
RC TISSUE=Brain, and Retina;
RX PubMed=16807332; DOI=10.1523/jneurosci.1163-06.2006;
RA Ahmed Z.M., Goodyear R., Riazuddin S., Lagziel A., Legan P.K., Behra M.,
RA Burgess S.M., Lilley K.S., Wilcox E.R., Riazuddin S., Griffith A.J.,
RA Frolenkov G.I., Belyantseva I.A., Richardson G.P., Friedman T.B.;
RT "The tip-link antigen, a protein associated with the transduction complex
RT of sensory hair cells, is protocadherin-15.";
RL J. Neurosci. 26:7022-7034(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Red jungle fowl;
RX PubMed=15592404; DOI=10.1038/nature03154;
RA Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P.,
RA Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B.,
RA Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C.,
RA Fulton R.S., Graves T.A., Kremitzki C., Layman D., Magrini V.,
RA McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O.,
RA Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W.,
RA Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D.,
RA Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K.,
RA Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L.,
RA Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B.,
RA Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M.,
RA Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M.,
RA Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S.,
RA Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M.,
RA Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M.,
RA Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A.,
RA Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S.,
RA Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J.,
RA Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J.,
RA Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E.,
RA Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M.,
RA Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A.,
RA Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E.,
RA Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S.,
RA Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E.,
RA Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R.,
RA Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R.,
RA Wilson R.K.;
RT "Sequence and comparative analysis of the chicken genome provide unique
RT perspectives on vertebrate evolution.";
RL Nature 432:695-716(2004).
CC -!- FUNCTION: Calcium-dependent cell-adhesion protein. Required for inner
CC ear neuroepithelial cell elaboration and cochlear function. Probably
CC involved in the maintenance of normal retinal function (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=11;
CC Name=1; Synonyms=CD1-1;
CC IsoId=Q0ZM14-1; Sequence=Displayed;
CC Name=2; Synonyms=CD1-2;
CC IsoId=Q0ZM14-2; Sequence=VSP_047426, VSP_047427;
CC Name=3; Synonyms=CD2/3-1;
CC IsoId=Q0ZM14-3; Sequence=VSP_047435;
CC Name=4; Synonyms=CD3-1;
CC IsoId=Q0ZM14-4; Sequence=VSP_047436;
CC Name=5; Synonyms=CD3-2;
CC IsoId=Q0ZM14-5; Sequence=VSP_047431, VSP_047434;
CC Name=6; Synonyms=CD3-3;
CC IsoId=Q0ZM14-6; Sequence=VSP_047429, VSP_047430;
CC Name=7; Synonyms=CD3-4;
CC IsoId=Q0ZM14-7; Sequence=VSP_047428, VSP_047433;
CC Name=8; Synonyms=CD3-5;
CC IsoId=Q0ZM14-8; Sequence=VSP_047425, VSP_047432;
CC Name=9; Synonyms=CD3-6;
CC IsoId=Q0ZM14-9; Sequence=VSP_047419, VSP_047420, VSP_047436;
CC Name=10; Synonyms=CD3-7;
CC IsoId=Q0ZM14-10; Sequence=VSP_047423, VSP_047424;
CC Name=11; Synonyms=CD3-8;
CC IsoId=Q0ZM14-11; Sequence=VSP_047421, VSP_047422;
CC -!- TISSUE SPECIFICITY: In the utricle, localizes to the distal region of
CC the kinocilium and near the tips of the stereocilia.
CC {ECO:0000269|PubMed:16807332}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABC79291.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
CC Sequence=ABC79292.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
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DR EMBL; DQ354419; ABC79282.1; -; mRNA.
DR EMBL; DQ354420; ABC79283.1; -; mRNA.
DR EMBL; DQ354421; ABC79284.1; -; mRNA.
DR EMBL; DQ354422; ABC79285.1; -; mRNA.
DR EMBL; DQ354423; ABC79286.1; -; mRNA.
DR EMBL; DQ354424; ABC79287.1; -; mRNA.
DR EMBL; DQ354425; ABC79288.1; -; mRNA.
DR EMBL; DQ354426; ABC79289.1; -; mRNA.
DR EMBL; DQ354427; ABC79290.1; -; mRNA.
DR EMBL; DQ354428; ABC79291.1; ALT_SEQ; mRNA.
DR EMBL; DQ354429; ABC79292.1; ALT_SEQ; mRNA.
DR EMBL; AADN03005146; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AADN02035256; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AADN02035257; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AADN02035258; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001038119.1; NM_001044654.1. [Q0ZM14-3]
DR RefSeq; XP_015143569.1; XM_015288083.1. [Q0ZM14-1]
DR RefSeq; XP_015143573.1; XM_015288087.1. [Q0ZM14-4]
DR AlphaFoldDB; Q0ZM14; -.
DR SMR; Q0ZM14; -.
DR STRING; 9031.ENSGALP00000004315; -.
DR PaxDb; Q0ZM14; -.
DR Ensembl; ENSGALT00000004324; ENSGALP00000004315; ENSGALG00000002744. [Q0ZM14-3]
DR Ensembl; ENSGALT00000044134; ENSGALP00000040727; ENSGALG00000002744. [Q0ZM14-1]
DR Ensembl; ENSGALT00000085003; ENSGALP00000060369; ENSGALG00000002744. [Q0ZM14-2]
DR Ensembl; ENSGALT00000086118; ENSGALP00000058882; ENSGALG00000002744. [Q0ZM14-8]
DR Ensembl; ENSGALT00000087430; ENSGALP00000060700; ENSGALG00000002744. [Q0ZM14-4]
DR Ensembl; ENSGALT00000088076; ENSGALP00000059801; ENSGALG00000002744. [Q0ZM14-5]
DR Ensembl; ENSGALT00000106410; ENSGALP00000071651; ENSGALG00000002744. [Q0ZM14-7]
DR GeneID; 423644; -.
DR KEGG; gga:423644; -.
DR CTD; 65217; -.
DR VEuPathDB; HostDB:geneid_423644; -.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000156675; -.
DR HOGENOM; CLU_001945_0_0_1; -.
DR OMA; PLRCEIY; -.
DR OrthoDB; 21247at2759; -.
DR PhylomeDB; Q0ZM14; -.
DR TreeFam; TF326779; -.
DR PRO; PR:Q0ZM14; -.
DR Proteomes; UP000000539; Chromosome 6.
DR Bgee; ENSGALG00000002744; Expressed in testis and 7 other tissues.
DR ExpressionAtlas; Q0ZM14; baseline and differential.
DR GO; GO:0098981; C:cholinergic synapse; IDA:SynGO.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0098793; C:presynapse; IDA:SynGO.
DR GO; GO:0032420; C:stereocilium; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0048839; P:inner ear development; IEA:InterPro.
DR GO; GO:0007605; P:sensory perception of sound; IEA:InterPro.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR041149; EC_dom.
DR InterPro; IPR030718; Protocadherin-15.
DR PANTHER; PTHR24028:SF11; PTHR24028:SF11; 1.
DR Pfam; PF00028; Cadherin; 8.
DR Pfam; PF18432; ECD; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 11.
DR SUPFAM; SSF49313; SSF49313; 10.
DR PROSITE; PS00232; CADHERIN_1; 4.
DR PROSITE; PS50268; CADHERIN_2; 10.
PE 1: Evidence at protein level;
KW Alternative splicing; Calcium; Cell adhesion; Cell membrane;
KW Direct protein sequencing; Disulfide bond; Membrane; Reference proteome;
KW Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..1899
FT /note="Protocadherin-15"
FT /id="PRO_0000422923"
FT TOPO_DOM 27..1376
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1377..1397
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1398..1899
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 38..147
FT /note="Cadherin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 148..265
FT /note="Cadherin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 278..395
FT /note="Cadherin 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 396..509
FT /note="Cadherin 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 510..616
FT /note="Cadherin 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 617..717
FT /note="Cadherin 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 719..819
FT /note="Cadherin 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 820..926
FT /note="Cadherin 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 927..1035
FT /note="Cadherin 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 1037..1144
FT /note="Cadherin 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 1145..1259
FT /note="Cadherin 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT REGION 1668..1687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1700..1721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1734..1820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1743..1775
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1776..1795
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1801..1815
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 32..120
FT /evidence="ECO:0000250"
FT VAR_SEQ 106
FT /note="D -> E (in isoform 9)"
FT /evidence="ECO:0000303|PubMed:16807332"
FT /id="VSP_047419"
FT VAR_SEQ 107..1269
FT /note="Missing (in isoform 9)"
FT /evidence="ECO:0000303|PubMed:16807332"
FT /id="VSP_047420"
FT VAR_SEQ 107
FT /note="P -> V (in isoform 11)"
FT /evidence="ECO:0000303|PubMed:16807332"
FT /id="VSP_047421"
FT VAR_SEQ 108..1899
FT /note="Missing (in isoform 11)"
FT /evidence="ECO:0000303|PubMed:16807332"
FT /id="VSP_047422"
FT VAR_SEQ 159
FT /note="L -> V (in isoform 10)"
FT /evidence="ECO:0000303|PubMed:16807332"
FT /id="VSP_047423"
FT VAR_SEQ 160..1899
FT /note="Missing (in isoform 10)"
FT /evidence="ECO:0000303|PubMed:16807332"
FT /id="VSP_047424"
FT VAR_SEQ 199..381
FT /note="TSNRTFDIPLTLSGAVVLRERLNYEEKTRYFVIVQANDRAQNLHERRTSTTT
FT LTVDVLDGDDLGPMFLPCVLVNNTRDCRPLTYQASLPELTDPVHVNPISVTPPIQAIDQ
FT DRNIQPPSDRPGILYSILVGTPEDYPQYFHMNLTTAELTLLKPINRDLHQKFDLVIKAE
FT QDNGHPLPAFANL -> WARKKRIKLIVDPEYETSSTGEDSAPDSSQRSRLNNPNIQNN
FT VNGNIYIAQNGSVVRTRRVCLANNLKVTSPVTLGKQFKKLDKLAVTHEENVPLNTLSKG
FT SSSSDKVNTRPCSVSFASSIGAENIVTKPGGSKMKSTEEQESVVDNEDTKEPLESHSEH
FT TQSDEEELWMGPWNNLHIPMTKL (in isoform 8)"
FT /evidence="ECO:0000303|PubMed:16807332"
FT /id="VSP_047425"
FT VAR_SEQ 199..232
FT /note="TSNRTFDIPLTLSGAVVLRERLNYEEKTRYFVIV -> SFSSLPFPTKQGKK
FT VSLRRRRSAESYKQLCFPCY (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16807332"
FT /id="VSP_047426"
FT VAR_SEQ 233..1899
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16807332"
FT /id="VSP_047427"
FT VAR_SEQ 293..384
FT /note="VHVNPISVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPQYFHMNLTT
FT AELTLLKPINRDLHQKFDLVIKAEQDNGHPLPAFANLHIE -> NVPLNTLSKGSSSSD
FT KVNTRPCSVSFASSIGAENIVTKPGGSKMKSTEEQESVVDNEDTKEPLESHSEHTQSDE
FT EELWMGPWNNLHIPMTKL (in isoform 7)"
FT /evidence="ECO:0000303|PubMed:16807332"
FT /id="VSP_047428"
FT VAR_SEQ 294..302
FT /note="HVNPISVTP -> PRWQTAGYQ (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:16807332"
FT /id="VSP_047429"
FT VAR_SEQ 303..1899
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:16807332"
FT /id="VSP_047430"
FT VAR_SEQ 367..618
FT /note="AEQDNGHPLPAFANLHIEVLDENNQKPYFTKSTYEGFILESSPVGTTISDSR
FT NLTSPLQITVLDNDVEETKDPQLHLFLNDYNTFFTVTQSGITRYLTLLQPVDREAQQLY
FT TFSMIASDGVQESTPVTVNIVVIDANDNSPTFSNISYNVKIYTDMGPGEGVIKLTAVDA
FT DEGPNGQIVYEILAGDQGDFIINDRTGLIAIAPGVVLSVGRSYALTVKASDSAPPAQRR
FT SSITTVYIEVLPPNNQSPPRFPQ -> ELSMESGIDPGQEYYGQDYYSYEHGYELPQYG
FT SRRRLLSPSGMYDEYGEVMVENDGGYYYSPHGSTAEEWARKKRIKLIVDPEYETSSTGE
FT DSAPDSSQRSRLNNPNIQNNVNGNIYIAQNGSVVRTRRVCLANNLKVTSPVTLGKQFKK
FT LDKLAVTHEENVPLNTLSKGSSSSDKVNTRPCSVSFASSIGAENIVTKPGGSKMKSTEE
FT QESVVDNEDTKEPLESHSEHTQSDEEELWMGPWNNLHIPMTKL (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:16807332"
FT /id="VSP_047431"
FT VAR_SEQ 382..1899
FT /note="Missing (in isoform 8)"
FT /evidence="ECO:0000303|PubMed:16807332"
FT /id="VSP_047432"
FT VAR_SEQ 385..1899
FT /note="Missing (in isoform 7)"
FT /evidence="ECO:0000303|PubMed:16807332"
FT /id="VSP_047433"
FT VAR_SEQ 619..1899
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:16807332"
FT /id="VSP_047434"
FT VAR_SEQ 1438..1899
FT /note="ILFLLYHFQQSRGKKSVLEEGDRQRVISSFASRAIEAHKQSNINGSLNNNLP
FT KSSSNITFLSDENPLTTQNPLYVEGVTQSPAAAGLLRKRSDALDTLSPMQLVLRDASLG
FT GSHRAWTVPAHVTKRHAPGSLSRPVIMDPVQWQQERLKAENEGTENQHSRVDISSPLFQ
FT KISGPTLTVKEKARQFEQQALQEMKQVKSPDVKSTRSPTHSICLQERDNTLEQSPKSVF
FT ASPCLRSSPLSSPTPCEVVEPEPSAVPSVIITHHDYPEELSPPPTRKPTPPSFRIKKPV
FT CQSFLAPQTKGEVTENIPDPPKTPPPPPPLLPPPPPSPPLLPPHPPTLPLASVPSSSSL
FT PSTQHLSPAKHSKSPAKQPAVPPPAAVPEPPPRRELKGILKNIQNLAAIEKSVANMYSQ
FT IDKNHVLPKHISKLKPVATPELPTPEAAAEHNQQNGNLSCVVEELEKRFPSQSTAL ->
FT MRGYAQQEQQQLLRPSLLRPEELSMESGIDPGQEYYGQDYYSYEHGYELPQYGSRRRLL
FT SPSGMYDEYGEVMVENDGGYYYSPHGSTAEEGMSQSRGPSSRGISQRAGAQIEGRPLDG
FT GMDLRHGSGRAYRTSQGRRKLKAVMHLSRVAVSAHKPVGRSESAHSPWKKAKIFPMILQ
FT KVKGSRKDSSYAKLMSARQADGEKSMIIRGSYFQKSTDDRPSMRKLNHVLKRISVSRKF
FT QEPTSKDAVHLGGKEEEERDEAKSGVSISITAESEHEESDYEKKKKRRRKYSSDESSAK
FT SSSSGSESEDKDYLTVTLDQDEATESTVDSDEESGHDIGDSDDGSGSSSSSESEEDSSE
FT EDSDEEESDSDEDDSLSQSSSTQSSFSKSGTSESSSRRSTGRSSTKSRGSSSRGRARRS
FT SQKSVSSNTSGASCRKTSGSSYKSKTSSASLEIEDTIEEVSEEDEQADAEQVGASPDET
FT IDNTKNKTVSKTSANAKSAKNAATEEDKRRKSGVNSGDNGDESAEEVDTDASDKEETVS
FT KNGSEISVTSKGTGGIKSTASATSGRTATSPDTETQSSDINWARKKRIKLIVDPEYETS
FT STGEDSAPDSSQRSRLNNPNIQNNVNGNIYIAQNGSVVRTRRVCLANNLKVTSPVTLGK
FT QFKKLDKLAVTHEENVPLNTLSKGSSSSDKVNTRPCSVSFASSIGAENIVTKPGGSKMK
FT STEEQESVVDNEDTKEPLESHSEHTQSDEEELWMGPWNNLHIPMTKL (in isoform
FT 3)"
FT /evidence="ECO:0000303|PubMed:16807332"
FT /id="VSP_047435"
FT VAR_SEQ 1438..1899
FT /note="ILFLLYHFQQSRGKKSVLEEGDRQRVISSFASRAIEAHKQSNINGSLNNNLP
FT KSSSNITFLSDENPLTTQNPLYVEGVTQSPAAAGLLRKRSDALDTLSPMQLVLRDASLG
FT GSHRAWTVPAHVTKRHAPGSLSRPVIMDPVQWQQERLKAENEGTENQHSRVDISSPLFQ
FT KISGPTLTVKEKARQFEQQALQEMKQVKSPDVKSTRSPTHSICLQERDNTLEQSPKSVF
FT ASPCLRSSPLSSPTPCEVVEPEPSAVPSVIITHHDYPEELSPPPTRKPTPPSFRIKKPV
FT CQSFLAPQTKGEVTENIPDPPKTPPPPPPLLPPPPPSPPLLPPHPPTLPLASVPSSSSL
FT PSTQHLSPAKHSKSPAKQPAVPPPAAVPEPPPRRELKGILKNIQNLAAIEKSVANMYSQ
FT IDKNHVLPKHISKLKPVATPELPTPEAAAEHNQQNGNLSCVVEELEKRFPSQSTAL ->
FT MRGYAQQEQQQLLRPSLLRPEELSMESGIDPGQEYYGQDYYSYEHGYELPQYGSRRRLL
FT SPSGMYDEYGEVMVENDGGYYYSPHGSTAEEWARKKRIKLIVDPEYETSSTGEDSAPDS
FT SQRSRLNNPNIQNNVNGNIYIAQNGSVVRTRRVCLANNLKVTSPVTLGKQFKKLDKLAV
FT THEENVPLNTLSKGSSSSDKVNTRPCSVSFASSIGAENIVTKPGGSKMKSTEEQESVVD
FT NEDTKEPLESHSEHTQSDEEELWMGPWNNLHIPMTKL (in isoform 4 and
FT isoform 9)"
FT /evidence="ECO:0000303|PubMed:16807332"
FT /id="VSP_047436"
SQ SEQUENCE 1899 AA; 209146 MW; AE7CD4A078E9B31B CRC64;
MLQQFCLWKW LAVGIAVATI LASSLAQNDE DCKLARTGPP ATIVPIDEES RNGTILVDNM
LIKGTAAGPD PTIELSLKDN VDYWVILDPI SQRLYLNSTG RVLDRDPPMS IQSIVVQVQC
VNKKVGTIIN HEVRIVVRDR NDNSPQFQQQ RYYVAVNELT PVGTTIFTGF SGNNGATDID
DGPNGQIEYV IQYNPNDKTS NRTFDIPLTL SGAVVLRERL NYEEKTRYFV IVQANDRAQN
LHERRTSTTT LTVDVLDGDD LGPMFLPCVL VNNTRDCRPL TYQASLPELT DPVHVNPISV
TPPIQAIDQD RNIQPPSDRP GILYSILVGT PEDYPQYFHM NLTTAELTLL KPINRDLHQK
FDLVIKAEQD NGHPLPAFAN LHIEVLDENN QKPYFTKSTY EGFILESSPV GTTISDSRNL
TSPLQITVLD NDVEETKDPQ LHLFLNDYNT FFTVTQSGIT RYLTLLQPVD REAQQLYTFS
MIASDGVQES TPVTVNIVVI DANDNSPTFS NISYNVKIYT DMGPGEGVIK LTAVDADEGP
NGQIVYEILA GDQGDFIIND RTGLIAIAPG VVLSVGRSYA LTVKASDSAP PAQRRSSITT
VYIEVLPPNN QSPPRFPQLM YSLEVSEAMR TGAILLNLQA FDREGDPIRY LIENGDPQQV
FNLSQSSGLL ALGKPLDRES TDRYILIVTA SDGRPDGTST ATVNIVVTDV NDNGPVFDMF
LPKNLSVQEE EANAFVGQVR ATDPDAGVNG QVHYSLANFK NLFRITSNGS IYTAVKLNRE
VRDYYELIVE ATDGAVDPRR STLTLAIKVL DIDDNSPVFT NASYSVLVPE NLPPGTVFLQ
IEAKDVDLGS NVTYRIRTQE ALEYFALNKY TGELSLLKSL DYESFSDTDA TFTFLVEAFD
SKGTMPPGLA TVTVRVKDMN DYSPVFSKTL YRGMVAPDAV KGTVITTVSA EDQDPPGTPA
SRVRYKVDVV QFPYSASIFD VEENSGRVVT RVNLNEEPST VFKLVVIAYD DGDPVKFNTT
TVEIAVLQPS VIPRFTQDEY RPPPVSESAP KGTVVTVVMA AALNQTIVYS IVSGNEEDVF
AINNRTGVIS VKKPLDYERV TSYELRVQAD SLQVVRSNLR VPSKSNTAKV FIEVKDENDH
APVFTKKMYI GGVSEDAKMF SSVLKVKADD KDTGNYSAMQ YRLIIPPIKD GKEGFVIEAY
TGLIKTAMLF KNMRRSYFKF QVIATDDYGK GLSSKADVLV SVVNQLDMQV IVSNVPPTLV
EQNKDQLIGI LERYVQDQIP GATVVVESIG ARRFGDGYSE EDYTKSDLMV YAIDPQTNRA
IMRNELFKFL DGKLLDINKE FQPYLGQGGR ILEIRTPDVV ANVKKQAQAV GYTEGALLAL
AVIIILCCMP AILIVMVSYR QRQAECAKTA RIQMALPAGK PASTAANNLY EELGDSTILF
LLYHFQQSRG KKSVLEEGDR QRVISSFASR AIEAHKQSNI NGSLNNNLPK SSSNITFLSD
ENPLTTQNPL YVEGVTQSPA AAGLLRKRSD ALDTLSPMQL VLRDASLGGS HRAWTVPAHV
TKRHAPGSLS RPVIMDPVQW QQERLKAENE GTENQHSRVD ISSPLFQKIS GPTLTVKEKA
RQFEQQALQE MKQVKSPDVK STRSPTHSIC LQERDNTLEQ SPKSVFASPC LRSSPLSSPT
PCEVVEPEPS AVPSVIITHH DYPEELSPPP TRKPTPPSFR IKKPVCQSFL APQTKGEVTE
NIPDPPKTPP PPPPLLPPPP PSPPLLPPHP PTLPLASVPS SSSLPSTQHL SPAKHSKSPA
KQPAVPPPAA VPEPPPRREL KGILKNIQNL AAIEKSVANM YSQIDKNHVL PKHISKLKPV
ATPELPTPEA AAEHNQQNGN LSCVVEELEK RFPSQSTAL
