PCD15_HUMAN
ID PCD15_HUMAN Reviewed; 1955 AA.
AC Q96QU1; A6NL19; C6ZEF5; C6ZEF6; C6ZEF7; Q5VY38; Q5VY39; Q6TRH8; Q8NDB9;
AC Q96QT8;
DT 31-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 186.
DE RecName: Full=Protocadherin-15;
DE Flags: Precursor;
GN Name=PCDH15; Synonyms=USH1F;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INVOLVEMENT IN
RP USHER SYNDROME TYPE 1F, AND VARIANT GLN-929.
RC TISSUE=Fetal brain;
RX PubMed=11487575; DOI=10.1093/hmg/10.16.1709;
RA Alagramam K.N., Yuan H., Kuehn M.H., Murcia C.L., Wayne S.,
RA Srisailpathy C.R.S., Lowry R.B., Knaus R., Van Laer L., Bernier F.P.,
RA Schwartz S., Lee C., Morton C.C., Mullins R.F., Ramesh A., Van Camp G.,
RA Hagemen G.S., Woychik R.P., Smith R.J.H.;
RT "Mutations in the novel protocadherin PCDH15 cause Usher syndrome type
RT 1F.";
RL Hum. Mol. Genet. 10:1709-1718(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND INVOLVEMENT IN USHER SYNDROME
RP TYPE 1F.
RX PubMed=11398101; DOI=10.1086/321277;
RA Ahmed Z.M., Riazuddin S., Bernstein S.L., Ahmed Z., Khan S., Griffith A.J.,
RA Morell R.J., Friedman T.B., Riazuddin S., Wilcox E.R.;
RT "Mutations of the protocadherin gene PCDH15 cause Usher syndrome type 1F.";
RL Am. J. Hum. Genet. 69:25-34(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND VARIANTS DFNB23 GLY-134 AND
RP ASP-262.
RX PubMed=14570705; DOI=10.1093/hmg/ddg358;
RA Ahmed Z.M., Riazuddin S., Ahmad J., Bernstein S.L., Guo Y., Sabar M.F.,
RA Sieving P., Riazuddin S., Griffith A.J., Friedman T.B., Belyantseva I.A.,
RA Wilcox E.R.;
RT "PCDH15 is expressed in the neurosensory epithelium of the eye and ear and
RT mutant alleles are responsible for both USH1F and DFNB23.";
RL Hum. Mol. Genet. 12:3215-3223(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4 AND 5), TISSUE SPECIFICITY, VARIANT
RP DFNB23 GLY-134, AND VARIANT USH1DF GLY-178.
RC TISSUE=Retina;
RX PubMed=18719945; DOI=10.1007/s00439-008-0543-3;
RA Ahmed Z.M., Riazuddin S., Aye S., Ali R.A., Venselaar H., Anwar S.,
RA Belyantseva P.P., Qasim M., Riazuddin S., Friedman T.B.;
RT "Gene structure and mutant alleles of PCDH15: nonsyndromic deafness DFNB23
RT and type 1 Usher syndrome.";
RL Hum. Genet. 124:215-223(2008).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND VARIANTS ALA-435
RP AND GLN-929.
RC TISSUE=Lymph node;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [7]
RP IDENTIFICATION OF ISOFORMS 1 AND 3, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, AND VARIANT ALA-19.
RX PubMed=16369489; DOI=10.1038/sj.onc.1209301;
RA Rouget-Quermalet V., Giustiniani J., Marie-Cardine A., Beaud G.,
RA Besnard F., Loyaux D., Ferrara P., Leroy K., Shimizu N., Gaulard P.,
RA Bensussan A., Schmitt C.;
RT "Protocadherin 15 (PCDH15): a new secreted isoform and a potential marker
RT for NK/T cell lymphomas.";
RL Oncogene 25:2807-2811(2006).
RN [8]
RP VARIANTS USH1F LYS-1342 AND THR-1867 DEL.
RX PubMed=15660226; DOI=10.1007/s00439-004-1227-2;
RA Ouyang X.M., Yan D., Du L.L., Hejtmancik J.F., Jacobson S.G., Nance W.E.,
RA Li A.R., Angeli S., Kaiser M., Newton V., Brown S.D.M., Balkany T.,
RA Liu X.Z.;
RT "Characterization of Usher syndrome type I gene mutations in an Usher
RT syndrome patient population.";
RL Hum. Genet. 116:292-299(2005).
RN [9]
RP INVOLVEMENT IN USH1DF.
RX PubMed=15537665; DOI=10.1093/hmg/ddi010;
RA Zheng Q.Y., Yan D., Ouyang X.M., Du L.L., Yu H., Chang B., Johnson K.R.,
RA Liu X.Z.;
RT "Digenic inheritance of deafness caused by mutations in genes encoding
RT cadherin 23 and protocadherin 15 in mice and humans.";
RL Hum. Mol. Genet. 14:103-111(2005).
RN [10]
RP VARIANTS USH1F GLN-134 AND ALA-1161 (ISOFORM 4), AND VARIANTS ALA-19;
RP SER-174; SER-380; ALA-435; GLN-929 AND SER-1273.
RX PubMed=22815625;
RA Jaijo T., Oshima A., Aller E., Carney C., Usami S., Millan J.M.,
RA Kimberling W.J.;
RT "Mutation screening of the PCDH15 gene in Spanish patients with Usher
RT syndrome type I.";
RL Mol. Vis. 18:1719-1726(2012).
RN [11]
RP VARIANT DFNB23 1576-GLN--LEU-1955 DEL.
RX PubMed=28281779; DOI=10.1089/gtmb.2016.0328;
RA Wang R., Han S., Khan A., Zhang X.;
RT "Molecular Analysis of Twelve Pakistani Families with Nonsyndromic or
RT Syndromic Hearing Loss.";
RL Genet. Test. Mol. Biomarkers 21:316-321(2017).
CC -!- FUNCTION: Calcium-dependent cell-adhesion protein. Essential for
CC maintenance of normal retinal and cochlear function.
CC -!- SUBUNIT: Antiparallel heterodimer with CDH23. Found in a complex with
CC TMIE and LHFPL5. Interacts with LHFPL5/TMHS; this interaction is
CC required for efficient localization to hair bundles. Interacts with
CC MYO7A. Interacts with USH1G; this interaction may recruit USH1G to the
CC plasma membrane. Interacts with TOMT. Isoforms CD1 and CD3 interact
CC with TMC1 (via N-terminus) and TMC2 (via N-terminus).
CC {ECO:0000250|UniProtKB:Q99PJ1}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}. Note=Efficient localization to the
CC plasma membrane requires the presence of LHFPL5. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: [Isoform 3]: Secreted.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1; Synonyms=A, CD1-1;
CC IsoId=Q96QU1-1; Sequence=Displayed;
CC Name=2; Synonyms=B;
CC IsoId=Q96QU1-2; Sequence=VSP_028257, VSP_028258;
CC Name=3; Synonyms=C;
CC IsoId=Q96QU1-3; Sequence=VSP_028259, VSP_028260;
CC Name=4; Synonyms=CD2-1;
CC IsoId=Q96QU1-4; Sequence=VSP_046616, VSP_046617, VSP_046622;
CC Name=5; Synonyms=CD3-1;
CC IsoId=Q96QU1-6; Sequence=VSP_046618, VSP_046621;
CC -!- TISSUE SPECIFICITY: Expressed in brain, lung, kidney, spleen and
CC testis. Found also in the inner and outer synaptic layers, and the
CC nerve fiber layer in adult and fetal retinas. Found in the supporting
CC cells, outer sulcus cells and spiral ganglion of fetal cochlea.
CC Expressed in cytotoxic tumor-derived T- and NK-cell lines as well as
CC biopsies of nasal NK/T-cell lymphomas. Not detected in normal or in
CC vitro activated peripheral blood cells, CD4 or CD8 lymphocytes or NK
CC cells. Isoform 3 is expressed in brain, heart, cerebellum and kidney.
CC CD1 isoforms, such as isoform 1, have a limited pattern of expression
CC and is detected in testis, retina and cochlea. CD2 isoforms, such as
CC isoforms 4 and 5, are expressed in heart, kidney, thymus, spleen,
CC testis, retina and cochlea. CD3 isoforms, such as isoform 6, are widely
CC expressed. {ECO:0000269|PubMed:11487575, ECO:0000269|PubMed:16369489,
CC ECO:0000269|PubMed:18719945}.
CC -!- DOMAIN: Cadherin repeats 1 and 2 mediate calcium-dependent heterophilic
CC interaction with CDH23. {ECO:0000250}.
CC -!- DOMAIN: Three calcium ions are usually bound at the interface of each
CC cadherin domain and rigidify the connections, imparting a strong
CC curvature to the full-length ectodomain. {ECO:0000250}.
CC -!- DISEASE: Usher syndrome 1F (USH1F) [MIM:602083]: USH is a genetically
CC heterogeneous condition characterized by the association of retinitis
CC pigmentosa with sensorineural deafness. Age at onset and differences in
CC auditory and vestibular function distinguish Usher syndrome type 1
CC (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3).
CC USH1 is characterized by profound congenital sensorineural deafness,
CC absent vestibular function and prepubertal onset of progressive
CC retinitis pigmentosa leading to blindness.
CC {ECO:0000269|PubMed:15660226, ECO:0000269|PubMed:22815625}. Note=The
CC disease is caused by variants affecting the gene represented in this
CC entry.
CC -!- DISEASE: Usher syndrome 1D/F (USH1DF) [MIM:601067]: USH1DF patients are
CC heterozygous for mutations in CDH23 and PCDH15, indicating a digenic
CC inheritance pattern. {ECO:0000269|PubMed:15537665,
CC ECO:0000269|PubMed:18719945}. Note=The disease is caused by variants
CC affecting distinct genetic loci, including the gene represented in this
CC entry.
CC -!- DISEASE: Deafness, autosomal recessive, 23 (DFNB23) [MIM:609533]: A
CC form of non-syndromic sensorineural hearing loss. Sensorineural
CC deafness results from damage to the neural receptors of the inner ear,
CC the nerve pathways to the brain, or the area of the brain that receives
CC sound information. {ECO:0000269|PubMed:14570705,
CC ECO:0000269|PubMed:18719945, ECO:0000269|PubMed:28281779}. Note=The
CC disease is caused by variants affecting the gene represented in this
CC entry.
CC -!- SEQUENCE CAUTION:
CC Sequence=ACF76477.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Probable cloning artifact.; Evidence={ECO:0000305};
CC -!- SEQUENCE CAUTION: [Isoform 3]:
CC Sequence=CAD38850.2; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY029205; AAK31581.1; -; mRNA.
DR EMBL; AY029237; AAK31804.1; -; mRNA.
DR EMBL; AY388963; AAR26468.1; -; mRNA.
DR EMBL; EU718480; ACF76476.1; -; mRNA.
DR EMBL; EU718481; ACF76477.1; ALT_SEQ; mRNA.
DR EMBL; EU718482; ACF76478.1; -; mRNA.
DR EMBL; AL834134; CAD38850.2; ALT_TERM; mRNA.
DR EMBL; AC013737; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC016817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC024073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC027671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL353784; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL356114; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL360214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL365496; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS7248.1; -. [Q96QU1-1]
DR CCDS; CCDS86093.1; -. [Q96QU1-3]
DR CCDS; CCDS86094.1; -. [Q96QU1-6]
DR CCDS; CCDS86095.1; -. [Q96QU1-4]
DR RefSeq; NP_149045.3; NM_033056.3. [Q96QU1-1]
DR RefSeq; XP_016872061.1; XM_017016572.1.
DR PDB; 4XHZ; X-ray; 2.80 A; A=816-1144.
DR PDB; 5T4M; X-ray; 2.24 A; A/B=263-616.
DR PDB; 5T4N; X-ray; 2.70 A; A/B=263-616.
DR PDB; 5ULY; X-ray; 2.64 A; A/B/C/D=143-390.
DR PDB; 6E8F; X-ray; 2.99 A; A/B/C=263-608.
DR PDB; 6EB5; X-ray; 2.60 A; A/B=143-390.
DR PDB; 6MFO; X-ray; 3.15 A; A=27-391.
DR PDB; 6N2E; X-ray; 2.90 A; A/B=27-391.
DR PDBsum; 4XHZ; -.
DR PDBsum; 5T4M; -.
DR PDBsum; 5T4N; -.
DR PDBsum; 5ULY; -.
DR PDBsum; 6E8F; -.
DR PDBsum; 6EB5; -.
DR PDBsum; 6MFO; -.
DR PDBsum; 6N2E; -.
DR AlphaFoldDB; Q96QU1; -.
DR SMR; Q96QU1; -.
DR BioGRID; 122407; 2.
DR IntAct; Q96QU1; 1.
DR MINT; Q96QU1; -.
DR STRING; 9606.ENSP00000363068; -.
DR ChEMBL; CHEMBL6112; -.
DR GlyGen; Q96QU1; 13 sites.
DR iPTMnet; Q96QU1; -.
DR PhosphoSitePlus; Q96QU1; -.
DR BioMuta; PCDH15; -.
DR DMDM; 116242702; -.
DR EPD; Q96QU1; -.
DR jPOST; Q96QU1; -.
DR MassIVE; Q96QU1; -.
DR MaxQB; Q96QU1; -.
DR PaxDb; Q96QU1; -.
DR PeptideAtlas; Q96QU1; -.
DR PRIDE; Q96QU1; -.
DR ProteomicsDB; 77903; -. [Q96QU1-1]
DR ProteomicsDB; 77904; -. [Q96QU1-2]
DR ProteomicsDB; 77905; -. [Q96QU1-3]
DR Antibodypedia; 27955; 99 antibodies from 20 providers.
DR DNASU; 65217; -.
DR Ensembl; ENST00000320301.11; ENSP00000322604.6; ENSG00000150275.20. [Q96QU1-1]
DR Ensembl; ENST00000373955.5; ENSP00000363066.1; ENSG00000150275.20. [Q96QU1-3]
DR Ensembl; ENST00000395445.6; ENSP00000378832.2; ENSG00000150275.20. [Q96QU1-4]
DR Ensembl; ENST00000616114.4; ENSP00000483745.1; ENSG00000150275.20. [Q96QU1-6]
DR GeneID; 65217; -.
DR KEGG; hsa:65217; -.
DR UCSC; uc001jju.2; human. [Q96QU1-1]
DR CTD; 65217; -.
DR DisGeNET; 65217; -.
DR GeneCards; PCDH15; -.
DR GeneReviews; PCDH15; -.
DR HGNC; HGNC:14674; PCDH15.
DR HPA; ENSG00000150275; Group enriched (adrenal gland, brain, retina).
DR MalaCards; PCDH15; -.
DR MIM; 276900; phenotype.
DR MIM; 601067; phenotype.
DR MIM; 602083; phenotype.
DR MIM; 605514; gene.
DR MIM; 609533; phenotype.
DR neXtProt; NX_Q96QU1; -.
DR OpenTargets; ENSG00000150275; -.
DR Orphanet; 90636; Autosomal recessive non-syndromic sensorineural deafness type DFNB.
DR Orphanet; 231169; Usher syndrome type 1.
DR PharmGKB; PA32999; -.
DR VEuPathDB; HostDB:ENSG00000150275; -.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000156675; -.
DR HOGENOM; CLU_286776_0_0_1; -.
DR InParanoid; Q96QU1; -.
DR PhylomeDB; Q96QU1; -.
DR PathwayCommons; Q96QU1; -.
DR Reactome; R-HSA-9662360; Sensory processing of sound by inner hair cells of the cochlea.
DR Reactome; R-HSA-9662361; Sensory processing of sound by outer hair cells of the cochlea.
DR SignaLink; Q96QU1; -.
DR SIGNOR; Q96QU1; -.
DR BioGRID-ORCS; 65217; 7 hits in 1060 CRISPR screens.
DR ChiTaRS; PCDH15; human.
DR GeneWiki; PCDH15; -.
DR GenomeRNAi; 65217; -.
DR Pharos; Q96QU1; Tbio.
DR PRO; PR:Q96QU1; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q96QU1; protein.
DR Bgee; ENSG00000150275; Expressed in left adrenal gland cortex and 94 other tissues.
DR ExpressionAtlas; Q96QU1; baseline and differential.
DR Genevisible; Q96QU1; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005615; C:extracellular space; IDA:HGNC-UCL.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0001750; C:photoreceptor outer segment; IDA:HGNC-UCL.
DR GO; GO:0032420; C:stereocilium; ISS:HGNC-UCL.
DR GO; GO:0045202; C:synapse; IDA:HGNC-UCL.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0050957; P:equilibrioception; IMP:HGNC-UCL.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0048839; P:inner ear development; IEA:InterPro.
DR GO; GO:0045494; P:photoreceptor cell maintenance; IMP:HGNC-UCL.
DR GO; GO:0050953; P:sensory perception of light stimulus; IMP:HGNC-UCL.
DR GO; GO:0007605; P:sensory perception of sound; IMP:HGNC-UCL.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR041149; EC_dom.
DR InterPro; IPR030718; Protocadherin-15.
DR PANTHER; PTHR24028:SF11; PTHR24028:SF11; 1.
DR Pfam; PF00028; Cadherin; 8.
DR Pfam; PF18432; ECD; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 11.
DR SUPFAM; SSF49313; SSF49313; 10.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 10.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Calcium; Cell adhesion; Cell membrane;
KW Deafness; Disease variant; Disulfide bond; Glycoprotein; Hearing; Membrane;
KW Non-syndromic deafness; Reference proteome; Repeat; Retinitis pigmentosa;
KW Secreted; Signal; Transmembrane; Transmembrane helix; Usher syndrome.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..1955
FT /note="Protocadherin-15"
FT /id="PRO_0000003998"
FT TOPO_DOM 27..1376
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1377..1397
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1398..1955
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 40..147
FT /note="Cadherin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 148..265
FT /note="Cadherin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 278..395
FT /note="Cadherin 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 396..509
FT /note="Cadherin 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 510..616
FT /note="Cadherin 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 617..717
FT /note="Cadherin 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 719..819
FT /note="Cadherin 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 820..926
FT /note="Cadherin 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 927..1035
FT /note="Cadherin 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 1037..1144
FT /note="Cadherin 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 1145..1259
FT /note="Cadherin 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT REGION 1426..1446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1601..1623
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1745..1766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1928..1955
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 52
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 97
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 201
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 419
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 559
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 662
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 724
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 768
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 821
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 851
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1064
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1084
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1175
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 32..120
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..1118
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14570705"
FT /id="VSP_028257"
FT VAR_SEQ 435
FT /note="D -> DVPPSGVP (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:18719945"
FT /id="VSP_046616"
FT VAR_SEQ 957..961
FT /note="GLPAS -> VSRRH (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_028259"
FT VAR_SEQ 962..1955
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_028260"
FT VAR_SEQ 1119..1125
FT /note="LRVPSKS -> MTFSHSG (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14570705"
FT /id="VSP_028258"
FT VAR_SEQ 1456..1776
FT /note="ILFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHVDGSLKSNKL
FT KSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQAKSKSLRGP
FT REKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNKRGSSNPL
FT LTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVSRTVELK
FT SEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPPNISPS
FT ACPLPPPPPISPPSPPPAPAPLAPPPDISPFSL -> MYEMPQYGSRRRLLPPAGQEEY
FT GEVVGEAEEEYEEEEEEPKKIKKPKVEIREPSEEEEVVVTIEKPPAAEPTYTTWKRARI
FT FPMIFKKVRGLADKRGIVDLEGEEWQRRLEEEDKDYLKLTLDQEEATESTVESEEESSS
FT DYTEYSEEESEFSESETTEEESESETPSEEEESSTPESEESESTESEGEKARKNIVLAR
FT RRPMVEEVKEVKGRKEEPQEEQKEPKMEEEEHSEEEESGPAPVEESTDPEAQDIPEEGS
FT AESASVEGGVESEEESESGSSSSSSESQSGGPWGYQVPAYDRSKNANQKKSPGANSEGY
FT NTAL (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:18719945"
FT /id="VSP_046617"
FT VAR_SEQ 1456..1675
FT /note="ILFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHVDGSLKSNKL
FT KSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQAKSKSLRGP
FT REKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNKRGSSNPL
FT LTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLP -> MYEMP
FT QYGSRRRLLPPAGQEEYGEVVGEAEEEYEEEEWARKRMIKLVVDREYETSSTGEDSAPE
FT CQRNRLHHPSIHSNINGNIYIAQNGSVVRTRRACLTDNLKVASPVRLGGPFKKLDKLAV
FT THEENVPLNTLSKGPFSTEKMNARPTLVTFAPCPVGTDNTAVKPLRNRLKSTVEQESMI
FT DSKNIKEALEFHSDHTQSDDEELWMGPWNNLHIPMTKL (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:18719945"
FT /id="VSP_046618"
FT VAR_SEQ 1676..1955
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:18719945"
FT /id="VSP_046621"
FT VAR_SEQ 1777..1955
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:18719945"
FT /id="VSP_046622"
FT VARIANT 19
FT /note="S -> A (in dbSNP:rs11004439)"
FT /evidence="ECO:0000269|PubMed:16369489,
FT ECO:0000269|PubMed:22815625"
FT /id="VAR_028289"
FT VARIANT 134
FT /note="R -> G (in DFNB23; dbSNP:rs137853003)"
FT /evidence="ECO:0000269|PubMed:14570705,
FT ECO:0000269|PubMed:18719945"
FT /id="VAR_024035"
FT VARIANT 134
FT /note="R -> Q (in USH1F; dbSNP:rs767966376)"
FT /evidence="ECO:0000269|PubMed:22815625"
FT /id="VAR_071696"
FT VARIANT 174
FT /note="N -> S (in dbSNP:rs145037203)"
FT /evidence="ECO:0000269|PubMed:22815625"
FT /id="VAR_071697"
FT VARIANT 178
FT /note="D -> G (in USH1DF)"
FT /evidence="ECO:0000269|PubMed:18719945"
FT /id="VAR_069297"
FT VARIANT 262
FT /note="G -> D (in DFNB23; dbSNP:rs137853002)"
FT /evidence="ECO:0000269|PubMed:14570705"
FT /id="VAR_024036"
FT VARIANT 380
FT /note="G -> S (in dbSNP:rs10825269)"
FT /evidence="ECO:0000269|PubMed:22815625"
FT /id="VAR_028290"
FT VARIANT 435
FT /note="D -> A (in dbSNP:rs4935502)"
FT /evidence="ECO:0000269|PubMed:17974005,
FT ECO:0000269|PubMed:22815625"
FT /id="VAR_028291"
FT VARIANT 929
FT /note="R -> Q (in dbSNP:rs2135720)"
FT /evidence="ECO:0000269|PubMed:11487575,
FT ECO:0000269|PubMed:17974005, ECO:0000269|PubMed:22815625"
FT /id="VAR_028292"
FT VARIANT 1273
FT /note="R -> S (in dbSNP:rs111033363)"
FT /evidence="ECO:0000269|PubMed:22815625"
FT /id="VAR_071698"
FT VARIANT 1342
FT /note="Q -> K (in USH1F; benign variant; dbSNP:rs61731387)"
FT /evidence="ECO:0000269|PubMed:15660226"
FT /id="VAR_024037"
FT VARIANT 1576..1955
FT /note="Missing (in DFNB23)"
FT /evidence="ECO:0000269|PubMed:28281779"
FT /id="VAR_079507"
FT VARIANT 1867
FT /note="Missing (in USH1F)"
FT /evidence="ECO:0000269|PubMed:15660226"
FT /id="VAR_024038"
FT CONFLICT 261
FT /note="L -> S (in Ref. 1; AAK31581)"
FT /evidence="ECO:0000305"
FT CONFLICT 467
FT /note="Q -> L (in Ref. 1; AAK31581)"
FT /evidence="ECO:0000305"
FT CONFLICT 1276
FT /note="Q -> R (in Ref. 1; AAK31581)"
FT /evidence="ECO:0000305"
FT STRAND 36..38
FT /evidence="ECO:0007829|PDB:6N2E"
FT STRAND 40..47
FT /evidence="ECO:0007829|PDB:6N2E"
FT STRAND 55..58
FT /evidence="ECO:0007829|PDB:6N2E"
FT STRAND 62..64
FT /evidence="ECO:0007829|PDB:6MFO"
FT STRAND 66..70
FT /evidence="ECO:0007829|PDB:6N2E"
FT STRAND 73..79
FT /evidence="ECO:0007829|PDB:6N2E"
FT HELIX 81..83
FT /evidence="ECO:0007829|PDB:6N2E"
FT STRAND 85..88
FT /evidence="ECO:0007829|PDB:6N2E"
FT TURN 89..92
FT /evidence="ECO:0007829|PDB:6N2E"
FT STRAND 93..96
FT /evidence="ECO:0007829|PDB:6N2E"
FT TURN 107..109
FT /evidence="ECO:0007829|PDB:6N2E"
FT STRAND 113..122
FT /evidence="ECO:0007829|PDB:6N2E"
FT TURN 123..125
FT /evidence="ECO:0007829|PDB:6N2E"
FT STRAND 128..138
FT /evidence="ECO:0007829|PDB:6N2E"
FT STRAND 146..150
FT /evidence="ECO:0007829|PDB:6EB5"
FT STRAND 152..157
FT /evidence="ECO:0007829|PDB:6EB5"
FT STRAND 165..167
FT /evidence="ECO:0007829|PDB:6EB5"
FT TURN 169..174
FT /evidence="ECO:0007829|PDB:6EB5"
FT STRAND 175..177
FT /evidence="ECO:0007829|PDB:6EB5"
FT HELIX 182..185
FT /evidence="ECO:0007829|PDB:6N2E"
FT STRAND 187..192
FT /evidence="ECO:0007829|PDB:6EB5"
FT HELIX 200..203
FT /evidence="ECO:0007829|PDB:6EB5"
FT TURN 209..211
FT /evidence="ECO:0007829|PDB:6EB5"
FT STRAND 214..216
FT /evidence="ECO:0007829|PDB:6EB5"
FT TURN 222..224
FT /evidence="ECO:0007829|PDB:6EB5"
FT STRAND 227..236
FT /evidence="ECO:0007829|PDB:6EB5"
FT STRAND 241..243
FT /evidence="ECO:0007829|PDB:5ULY"
FT STRAND 247..257
FT /evidence="ECO:0007829|PDB:6EB5"
FT STRAND 264..266
FT /evidence="ECO:0007829|PDB:5T4M"
FT STRAND 281..287
FT /evidence="ECO:0007829|PDB:5T4M"
FT HELIX 292..295
FT /evidence="ECO:0007829|PDB:5T4M"
FT STRAND 300..302
FT /evidence="ECO:0007829|PDB:6EB5"
FT STRAND 305..307
FT /evidence="ECO:0007829|PDB:6E8F"
FT STRAND 309..311
FT /evidence="ECO:0007829|PDB:5T4M"
FT STRAND 313..315
FT /evidence="ECO:0007829|PDB:6EB5"
FT HELIX 316..318
FT /evidence="ECO:0007829|PDB:6EB5"
FT STRAND 322..331
FT /evidence="ECO:0007829|PDB:5T4M"
FT HELIX 334..337
FT /evidence="ECO:0007829|PDB:5T4M"
FT STRAND 338..340
FT /evidence="ECO:0007829|PDB:5T4M"
FT TURN 342..344
FT /evidence="ECO:0007829|PDB:5T4M"
FT STRAND 347..349
FT /evidence="ECO:0007829|PDB:5T4M"
FT TURN 355..357
FT /evidence="ECO:0007829|PDB:5T4M"
FT STRAND 360..372
FT /evidence="ECO:0007829|PDB:5T4M"
FT STRAND 377..386
FT /evidence="ECO:0007829|PDB:5T4M"
FT STRAND 394..405
FT /evidence="ECO:0007829|PDB:5T4M"
FT STRAND 415..417
FT /evidence="ECO:0007829|PDB:5T4M"
FT STRAND 426..429
FT /evidence="ECO:0007829|PDB:5T4M"
FT TURN 431..433
FT /evidence="ECO:0007829|PDB:6E8F"
FT STRAND 442..447
FT /evidence="ECO:0007829|PDB:5T4M"
FT TURN 449..451
FT /evidence="ECO:0007829|PDB:5T4M"
FT STRAND 452..454
FT /evidence="ECO:0007829|PDB:5T4M"
FT STRAND 456..461
FT /evidence="ECO:0007829|PDB:5T4M"
FT STRAND 463..467
FT /evidence="ECO:0007829|PDB:5T4M"
FT TURN 471..473
FT /evidence="ECO:0007829|PDB:5T4M"
FT STRAND 476..484
FT /evidence="ECO:0007829|PDB:5T4M"
FT STRAND 493..500
FT /evidence="ECO:0007829|PDB:5T4M"
FT STRAND 512..519
FT /evidence="ECO:0007829|PDB:5T4M"
FT STRAND 527..530
FT /evidence="ECO:0007829|PDB:5T4M"
FT HELIX 539..541
FT /evidence="ECO:0007829|PDB:5T4M"
FT STRAND 544..550
FT /evidence="ECO:0007829|PDB:5T4M"
FT STRAND 555..558
FT /evidence="ECO:0007829|PDB:5T4M"
FT TURN 560..562
FT /evidence="ECO:0007829|PDB:5T4M"
FT STRAND 564..567
FT /evidence="ECO:0007829|PDB:5T4M"
FT STRAND 578..587
FT /evidence="ECO:0007829|PDB:5T4M"
FT TURN 591..593
FT /evidence="ECO:0007829|PDB:5T4M"
FT STRAND 596..606
FT /evidence="ECO:0007829|PDB:5T4M"
FT STRAND 818..829
FT /evidence="ECO:0007829|PDB:4XHZ"
FT STRAND 837..840
FT /evidence="ECO:0007829|PDB:4XHZ"
FT TURN 846..848
FT /evidence="ECO:0007829|PDB:4XHZ"
FT STRAND 853..856
FT /evidence="ECO:0007829|PDB:4XHZ"
FT HELIX 859..861
FT /evidence="ECO:0007829|PDB:4XHZ"
FT TURN 862..864
FT /evidence="ECO:0007829|PDB:4XHZ"
FT STRAND 865..867
FT /evidence="ECO:0007829|PDB:4XHZ"
FT TURN 869..871
FT /evidence="ECO:0007829|PDB:4XHZ"
FT STRAND 873..878
FT /evidence="ECO:0007829|PDB:4XHZ"
FT HELIX 882..884
FT /evidence="ECO:0007829|PDB:4XHZ"
FT STRAND 891..899
FT /evidence="ECO:0007829|PDB:4XHZ"
FT STRAND 908..917
FT /evidence="ECO:0007829|PDB:4XHZ"
FT STRAND 924..927
FT /evidence="ECO:0007829|PDB:4XHZ"
FT STRAND 929..935
FT /evidence="ECO:0007829|PDB:4XHZ"
FT STRAND 944..947
FT /evidence="ECO:0007829|PDB:4XHZ"
FT STRAND 950..952
FT /evidence="ECO:0007829|PDB:4XHZ"
FT HELIX 959..961
FT /evidence="ECO:0007829|PDB:4XHZ"
FT STRAND 964..968
FT /evidence="ECO:0007829|PDB:4XHZ"
FT HELIX 973..978
FT /evidence="ECO:0007829|PDB:4XHZ"
FT STRAND 979..981
FT /evidence="ECO:0007829|PDB:4XHZ"
FT TURN 983..985
FT /evidence="ECO:0007829|PDB:4XHZ"
FT STRAND 987..992
FT /evidence="ECO:0007829|PDB:4XHZ"
FT STRAND 1001..1009
FT /evidence="ECO:0007829|PDB:4XHZ"
FT STRAND 1012..1014
FT /evidence="ECO:0007829|PDB:4XHZ"
FT STRAND 1017..1026
FT /evidence="ECO:0007829|PDB:4XHZ"
FT HELIX 1029..1031
FT /evidence="ECO:0007829|PDB:4XHZ"
FT STRAND 1034..1036
FT /evidence="ECO:0007829|PDB:4XHZ"
FT STRAND 1038..1040
FT /evidence="ECO:0007829|PDB:4XHZ"
FT STRAND 1054..1057
FT /evidence="ECO:0007829|PDB:4XHZ"
FT STRAND 1067..1074
FT /evidence="ECO:0007829|PDB:4XHZ"
FT STRAND 1080..1082
FT /evidence="ECO:0007829|PDB:4XHZ"
FT TURN 1084..1086
FT /evidence="ECO:0007829|PDB:4XHZ"
FT STRAND 1088..1091
FT /evidence="ECO:0007829|PDB:4XHZ"
FT TURN 1097..1099
FT /evidence="ECO:0007829|PDB:4XHZ"
FT STRAND 1102..1111
FT /evidence="ECO:0007829|PDB:4XHZ"
FT HELIX 1112..1115
FT /evidence="ECO:0007829|PDB:4XHZ"
FT TURN 1116..1118
FT /evidence="ECO:0007829|PDB:4XHZ"
FT STRAND 1127..1135
FT /evidence="ECO:0007829|PDB:4XHZ"
FT VARIANT Q96QU1-4:1611
FT /note="E -> A (in USH1F; dbSNP:rs11003863)"
FT /evidence="ECO:0000269|PubMed:22815625"
FT /id="VAR_082801"
SQ SEQUENCE 1955 AA; 216069 MW; 23BA3A237CB188E7 CRC64;
MFRQFYLWTC LASGIILGSL FEICLGQYDD DCKLARGGPP ATIVAIDEES RNGTILVDNM
LIKGTAGGPD PTIELSLKDN VDYWVLMDPV KQMLFLNSTG RVLDRDPPMN IHSIVVQVQC
INKKVGTIIY HEVRIVVRDR NDNSPTFKHE SYYATVNELT PVGTTIFTGF SGDNGATDID
DGPNGQIEYV IQYNPDDPTS NDTFEIPLML TGNIVLRKRL NYEDKTRYFV IIQANDRAQN
LNERRTTTTT LTVDVLDGDD LGPMFLPCVL VPNTRDCRPL TYQAAIPELR TPEELNPIIV
TPPIQAIDQD RNIQPPSDRP GILYSILVGT PEDYPRFFHM HPRTAELSLL EPVNRDFHQK
FDLVIKAEQD NGHPLPAFAG LHIEILDENN QSPYFTMPSY QGYILESAPV GATISDSLNL
TSPLRIVALD KDIEDTKDPE LHLFLNDYTS VFTVTQTGIT RYLTLLQPVD REEQQTYTFS
ITAFDGVQES EPVIVNIQVM DANDNTPTFP EISYDVYVYT DMRPGDSVIQ LTAVDADEGS
NGEITYEILV GAQGDFIINK TTGLITIAPG VEMIVGRTYA LTVQAADNAP PAERRNSICT
VYIEVLPPNN QSPPRFPQLM YSLEISEAMR VGAVLLNLQA TDREGDSITY AIENGDPQRV
FNLSETTGIL TLGKALDRES TDRYILIITA SDGRPDGTST ATVNIVVTDV NDNAPVFDPY
LPRNLSVVEE EANAFVGQVK ATDPDAGING QVHYSLGNFN NLFRITSNGS IYTAVKLNRE
VRDYYELVVV ATDGAVHPRH STLTLAIKVL DIDDNSPVFT NSTYTVLVEE NLPAGTTILQ
IEAKDVDLGA NVSYRIRSPE VKHFFALHPF TGELSLLRSL DYEAFPDQEA SITFLVEAFD
IYGTMPPGIA TVTVIVKDMN DYPPVFSKRI YKGMVAPDAV KGTPITTVYA EDADPPGLPA
SRVRYRVDDV QFPYPASIFE VEEDSGRVIT RVNLNEEPTT IFKLVVVAFD DGEPVMSSSA
TVKILVLHPG EIPRFTQEEY RPPPVSELAT KGTMVGVISA AAINQSIVYS IVSGNEEDTF
GINNITGVIY VNGPLDYETR TSYVLRVQAD SLEVVLANLR VPSKSNTAKV YIEIQDENNH
PPVFQKKFYI GGVSEDARMF TSVLRVKATD KDTGNYSVMA YRLIIPPIKE GKEGFVVETY
TGLIKTAMLF HNMRRSYFKF QVIATDDYGK GLSGKADVLV SVVNQLDMQV IVSNVPPTLV
EKKIEDLTEI LDRYVQEQIP GAKVVVESIG ARRHGDAFSL EDYTKCDLTV YAIDPQTNRA
IDRNELFKFL DGKLLDINKD FQPYYGEGGR ILEIRTPEAV TSIKKRGESL GYTEGALLAL
AFIIILCCIP AILVVLVSYR QFKVRQAECT KTARIQAALP AAKPAVPAPA PVAAPPPPPP
PPPGAHLYEE LGDSSILFLL YHFQQSRGNN SVSEDRKHQQ VVMPFSSNTI EAHKSAHVDG
SLKSNKLKSA RKFTFLSDED DLSAHNPLYK ENISQVSTNS DISQRTDFVD PFSPKIQAKS
KSLRGPREKI QRLWSQSVSL PRRLMRKVPN RPEIIDLQQW QGTRQKAENE NTGICTNKRG
SSNPLLTTEE ANLTEKEEIR QGETLMIEGT EQLKSLSSDS SFCFPRPHFS FSTLPTVSRT
VELKSEPNVI SSPAECSLEL SPSRPCVLHS SLSRRETPIC MLPIETERNI FENFAHPPNI
SPSACPLPPP PPISPPSPPP APAPLAPPPD ISPFSLFCPP PSPPSIPLPL PPPTFFPLSV
STSGPPTPPL LPPFPTPLPP PPPSIPCPPP PSASFLSTEC VCITGVKCTT NLMPAEKIKS
SMTQLSTTTV CKTDPQREPK GILRHVKNLA ELEKSVANMY SQIEKNYLRT NVSELQTMCP
SEVTNMEITS EQNKGSLNNI VEGTEKQSHS QSTSL
