ID   PCD18_BOVIN             Reviewed;        1134 AA.
AC   A7MB46;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Protocadherin-18;
DE   Flags: Precursor;
GN   Name=PCDH18;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Potential calcium-dependent cell-adhesion protein.
CC   -!- SUBUNIT: Interacts with DAB1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}.
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DR   EMBL; BC151333; AAI51334.1; -; mRNA.
DR   RefSeq; NP_001095699.1; NM_001102229.2.
DR   AlphaFoldDB; A7MB46; -.
DR   SMR; A7MB46; -.
DR   STRING; 9913.ENSBTAP00000020655; -.
DR   PaxDb; A7MB46; -.
DR   PRIDE; A7MB46; -.
DR   GeneID; 539464; -.
DR   KEGG; bta:539464; -.
DR   CTD; 54510; -.
DR   eggNOG; KOG3594; Eukaryota.
DR   InParanoid; A7MB46; -.
DR   OrthoDB; 64478at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007420; P:brain development; ISS:UniProtKB.
DR   GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR013164; Cadherin_N.
DR   InterPro; IPR030714; Protocadherin-18.
DR   PANTHER; PTHR24028:SF9; PTHR24028:SF9; 1.
DR   Pfam; PF00028; Cadherin; 5.
DR   Pfam; PF08266; Cadherin_2; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 6.
DR   SUPFAM; SSF49313; SSF49313; 5.
DR   PROSITE; PS00232; CADHERIN_1; 5.
DR   PROSITE; PS50268; CADHERIN_2; 6.
PE   2: Evidence at transcript level;
KW   Calcium; Cell adhesion; Cell membrane; Glycoprotein; Membrane;
KW   Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..1134
FT                   /note="Protocadherin-18"
FT                   /id="PRO_0000352393"
FT   TOPO_DOM        28..699
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        700..720
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        721..1134
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          28..137
FT                   /note="Cadherin 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          138..246
FT                   /note="Cadherin 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          247..354
FT                   /note="Cadherin 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          361..465
FT                   /note="Cadherin 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          466..576
FT                   /note="Cadherin 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          582..697
FT                   /note="Cadherin 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   REGION          768..800
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          868..888
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          892..1134
FT                   /note="Interaction with DAB1"
FT                   /evidence="ECO:0000250"
FT   REGION          941..1003
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        967..994
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        103
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        269
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        559
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1134 AA;  125864 MW;  1685D1AE8DF19817 CRC64;
     MYQMNAKMHF TFVFALLVVS FNLDVLGKNL KYRIYEEQRV GSVIARLSED VADVLVKLPN
     PSTVRFRAMQ RGNTPLLVVN EDNGEISIGA KIDREQLCQK NLNCSIEFDV ITLPTEHLQL
     FHIEVEVLDI NDNSPQFSRS LIPIEISESA AVGTRIPLDS AFDPDVGENS LHTYSLSAND
     FFNIEVRTRT DGAKYAELIV VRELDRELKS SYELQLTASD MGVPQRSGSS ILKISISDSN
     DNSPAFEQQS YIIQLLENSP VGTLLLDLNA TDPDEGANGK IVYSFSSHVS PKIIETFKID
     SERGHLTLFK QVDYEITKSY EIDVQAQDLG PNSIPAHCKI IIKVVDVNDN KPEISINLMS
     PGKEEISYIF EGDPIDTFVA LVRVQDKDSG LNGEIVCKLH GHGHFKLQKT YENNYLILTN
     ATLDREKRSE YSLTVIAEDK GTPSLSTVKH FTVQINDIND NPPHFQRSRY EFAISENNSP
     GAYITTVTAT DPDLGENGQV TYTILESFIL GSSITTYDTI DPSNGAIYAL RIFDHEEVSQ
     ITFVVEARDG GSPKQLVSNT TVVLTIIDEN DNVPVVIGPA LRNNTAEISI PKGAESGFHV
     TRIRAIDRDS GVNAELSCSI VAGNEENIFV IDPRSCDIHT NVSMESVPYT EWELSVVIQD
     KGNPQLHTKV LLKCVIFEYA ESVTSTAMTS VSQAPLDVSM IIIISLGAIC AVLLVIMVLF
     ATRCNREKKD TRSYNCRVAE STYQHHPKRP SRQIHKGDIT LVPTVNGTLP IRSHHRSSPS
     SSPTLERGQM GSRQSHNSHQ SLNSLVTISS NHVPENFSLE LTHATPAVEV SQLLSMLHQG
     QYQPRPSFRG NKYSRSYRYA LQDMDKFSLK DSGRGDSEAG DSDYDLGRDS PIDRLLGEGF
     SDLFLTDGRI PAAMRLCTEE CRVLGHSDQC WMPPLPSPSS DYRSNMFIPG EEFPAQPQQQ
     HPHQSLEDDV QPVDSGEKKK SFSTFGKDSP SEEDSGDTST SSLLSEMSSV FQRLLPASLD
     TYSECTEMDR SNSLERRKGP LPAKTVGYPQ GVAAWAASTH FQNPTNNSGP PLGTHSSVQP
     SSKWLPAMEE IPENYEEDDF DNVLNHLNDG KHELMDASEL VAEINKLLQD VRQS