PCD20_MOUSE
ID PCD20_MOUSE Reviewed; 952 AA.
AC Q8BIZ0; E9QK76; Q8BIV2;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 18-SEP-2013, sequence version 3.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Protocadherin-20;
DE Flags: Precursor;
GN Name=Pcdh20;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Hippocampus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Potential calcium-dependent cell-adhesion protein.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC34009.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK049965; BAC34009.1; ALT_INIT; mRNA.
DR EMBL; AK083114; BAC38766.1; -; mRNA.
DR EMBL; AC164553; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS27306.1; -.
DR RefSeq; NP_848800.3; NM_178685.5.
DR AlphaFoldDB; Q8BIZ0; -.
DR SMR; Q8BIZ0; -.
DR STRING; 10090.ENSMUSP00000054774; -.
DR GlyGen; Q8BIZ0; 8 sites.
DR iPTMnet; Q8BIZ0; -.
DR PhosphoSitePlus; Q8BIZ0; -.
DR MaxQB; Q8BIZ0; -.
DR PaxDb; Q8BIZ0; -.
DR PRIDE; Q8BIZ0; -.
DR ProteomicsDB; 289317; -.
DR DNASU; 219257; -.
DR Ensembl; ENSMUST00000061628; ENSMUSP00000054774; ENSMUSG00000050505.
DR Ensembl; ENSMUST00000192557; ENSMUSP00000141860; ENSMUSG00000050505.
DR GeneID; 219257; -.
DR KEGG; mmu:219257; -.
DR UCSC; uc007uuh.2; mouse.
DR CTD; 64881; -.
DR MGI; MGI:2443376; Pcdh20.
DR VEuPathDB; HostDB:ENSMUSG00000050505; -.
DR eggNOG; ENOG502QU9U; Eukaryota.
DR GeneTree; ENSGT00940000156743; -.
DR HOGENOM; CLU_006480_5_2_1; -.
DR InParanoid; Q8BIZ0; -.
DR OMA; NCFASYS; -.
DR OrthoDB; 82835at2759; -.
DR PhylomeDB; Q8BIZ0; -.
DR TreeFam; TF320624; -.
DR BioGRID-ORCS; 219257; 4 hits in 72 CRISPR screens.
DR PRO; PR:Q8BIZ0; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q8BIZ0; protein.
DR Bgee; ENSMUSG00000050505; Expressed in utricle of membranous labyrinth and 117 other tissues.
DR Genevisible; Q8BIZ0; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR Pfam; PF00028; Cadherin; 5.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 7.
DR SUPFAM; SSF49313; SSF49313; 6.
DR PROSITE; PS00232; CADHERIN_1; 5.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 2: Evidence at transcript level;
KW Calcium; Cell adhesion; Cell membrane; Glycoprotein; Membrane;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..60
FT /evidence="ECO:0000255"
FT CHAIN 61..952
FT /note="Protocadherin-20"
FT /id="PRO_0000004006"
FT TOPO_DOM 61..891
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 892..912
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 913..952
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 64..210
FT /note="Cadherin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 211..321
FT /note="Cadherin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 322..536
FT /note="Cadherin 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 537..640
FT /note="Cadherin 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 641..743
FT /note="Cadherin 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 747..864
FT /note="Cadherin 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT CARBOHYD 135
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 327
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 333
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 681
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 749
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 804
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 845
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 850
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 720
FT /note="E -> G (in Ref. 1; BAC38766)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 952 AA; 104737 MW; B5E3BC6FFDC84EB4 CRC64;
MRGRGNARSL LVQAVSLRPA TWHPCLDMGH LHRPSSRTSH RNLPHVFLLF LFVGPFNCLA
SYSRATELLY SLNEGLPAGV LIGSLAEDLR LLPRASGRQN QQLLHPERTA SEGNPPLSFS
LASGGLSGQY VTLNNRSGEL HTSAQEIDRE ALCLDGGGGA AWAGSTSIAS SPSSDSCLLL
LDVLVLPQEY FRFVKVKIAI RDINDNAPQF PISEISVWVP ENSPVNTRLA IEHPAVDPDV
GINGVQTYRL LDYHGMFTLD VEENENGERT PYLIVMGALD RETQDQYVSI IIAEDGGSPP
LLGSATLTIG ISDINDNCPL FIDSQINVTV YGNATVGTPV ATVQAVDRDL GTNAQITYSY
SQKVPQETKD LFHLDEVTGV IKLSSKIGGS VLQTHKLTIL ANGPGCIPAV ITALVSIIKV
VFRPPEIVPR YIANEVDGVV YLKELEPVNT PIAFFTIRDP EGKYKINCFL DGEGPFRLAP
YKPYNNEYLL ETTKPMDYEV QSFYEIAVVA WNSEGFHVKR IIKVQLLDDN DNAPVFLQPL
IELTIEENNA PNAFLTKLYA TDADSGEMGR VSYFLGPDAP SYFSLDSVTG ILTVSTQLDR
EEKEKYRYTV RAVDCGTPPR ESVATVALTV LDKNDNSPRF INKDFSFFVP ENFPGYGEIG
VISVTDADAG RNGWVALSVM NQSDIFVIDT GKGMLRAKVS LDREQQSSYT LWVEAVDGGE
PALSSTTKIT ILLLDINDNP PLVLFPQSNM SYLLVLPSTL PGSPVTEVYA VDKDTGMNAV
IAYSIIGRRG PRPESFRIDP KTGNITLEEA LLQTDYGLHR LLVKVSDHGY PEPLHSTVMV
NLFVNDTVSN ESYIESLLRK EPEINIEEKE PQISIEPTHR KVESMSCMPT LVALSVISLG
SITLVTGMGI YICLRKGKKH HREDDNLEVQ IPLKGKIDLC MRERKPVDIS NI
