ID   A38_VAR67               Reviewed;         277 AA.
AC   P0DST5; P33853;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   03-AUG-2022, entry version 7.
DE   RecName: Full=Protein A38;
GN   ORFNames=A38L, A41L;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
CC   -!- FUNCTION: Promotes, when overexpressed, the influx of extracellular
CC       Ca2+, leading to membrane permeability and host cell necrosis.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae A38 protein family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X69198; CAA49088.1; -; Genomic_DNA.
DR   PIR; F36852; F36852.
DR   RefSeq; NP_042191.1; NC_001611.1.
DR   SMR; P0DST5; -.
DR   GeneID; 1486522; -.
DR   KEGG; vg:1486522; -.
DR   Proteomes; UP000002060; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0070053; F:thrombospondin receptor activity; IEA:InterPro.
DR   GO; GO:0022409; P:positive regulation of cell-cell adhesion; IEA:InterPro.
DR   GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR006704; CD47.
DR   InterPro; IPR013147; CD47-like_TM.
DR   InterPro; IPR013270; CD47_Vset.
DR   InterPro; IPR013783; Ig-like_fold.
DR   PANTHER; PTHR10613; PTHR10613; 1.
DR   Pfam; PF04549; CD47; 1.
DR   Pfam; PF08204; V-set_CD47; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Host membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..277
FT                   /note="Protein A38"
FT                   /id="PRO_0000099326"
FT   TRANSMEM        124..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        186..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        29
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        58
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   277 AA;  31595 MW;  16A7AC95E215D57E CRC64;
     MLRVRILLIY LCTFVVITST KTIEYTACND TIIIPCTIDN PTKYIRWKLD NHNILTYNKT
     SKTIILSKWH TSAKLHSLSD NDVSLIIKYK DILPGTYTCE DNTGIKSTVK LVQRHTNWFN
     DHHTMLMFIF TGITLFLLFL EIAYTSISVV FSTNLGILQV FGCIIAMIEL CGAFLFYPSM
     FTLRHIIGLL MMTLPSIFLI ITKVFSFWLL CKLSCAVHLI IYYQLAGYIL TVLGLGLSLK
     ECVDGTLLLS GLGTIMVSEH FSLLFLVCFP STQRDYY