PCDAA_HUMAN
ID PCDAA_HUMAN Reviewed; 948 AA.
AC Q9Y5I2; A1L493; O75280; Q9NRU2;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Protocadherin alpha-10;
DE Short=PCDH-alpha-10;
DE Flags: Precursor;
GN Name=PCDHA10; Synonyms=CNRS8;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Brain;
RX PubMed=10380929; DOI=10.1016/s0092-8674(00)80789-8;
RA Wu Q., Maniatis T.;
RT "A striking organization of a large family of human neural cadherin-like
RT cell adhesion genes.";
RL Cell 97:779-790(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND VARIANT ARG-439.
RC TISSUE=Brain;
RA Kools P.F.J., van Roy F.;
RT "Alternative splicing within the human CNR family of protocadherins (PCDH-
RT alpha) produces transcripts encoding secreted proteins.";
RL Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Potential calcium-dependent cell-adhesion protein. May be
CC involved in the establishment and maintenance of specific neuronal
CC connections in the brain.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Comment=Additional isoforms seem to exist.;
CC Name=1;
CC IsoId=Q9Y5I2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9Y5I2-2; Sequence=VSP_000690;
CC Name=3;
CC IsoId=Q9Y5I2-3; Sequence=VSP_000691, VSP_000692;
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DR EMBL; AF152306; AAD43700.1; -; mRNA.
DR EMBL; AF152475; AAD43736.1; -; mRNA.
DR EMBL; AF169689; AAF89329.1; -; mRNA.
DR EMBL; AC005609; AAC34317.1; -; Genomic_DNA.
DR EMBL; BC130447; AAI30448.1; -; mRNA.
DR CCDS; CCDS34255.1; -. [Q9Y5I2-2]
DR CCDS; CCDS54921.1; -. [Q9Y5I2-1]
DR CCDS; CCDS75325.1; -. [Q9Y5I2-3]
DR RefSeq; NP_061724.1; NM_018901.3. [Q9Y5I2-1]
DR RefSeq; NP_114065.1; NM_031859.2. [Q9Y5I2-3]
DR RefSeq; NP_114066.1; NM_031860.2. [Q9Y5I2-2]
DR AlphaFoldDB; Q9Y5I2; -.
DR SMR; Q9Y5I2; -.
DR BioGRID; 121079; 20.
DR IntAct; Q9Y5I2; 20.
DR STRING; 9606.ENSP00000304234; -.
DR GlyGen; Q9Y5I2; 3 sites.
DR iPTMnet; Q9Y5I2; -.
DR PhosphoSitePlus; Q9Y5I2; -.
DR BioMuta; PCDHA10; -.
DR DMDM; 13878433; -.
DR EPD; Q9Y5I2; -.
DR jPOST; Q9Y5I2; -.
DR MassIVE; Q9Y5I2; -.
DR PaxDb; Q9Y5I2; -.
DR PeptideAtlas; Q9Y5I2; -.
DR PRIDE; Q9Y5I2; -.
DR ProteomicsDB; 86408; -. [Q9Y5I2-1]
DR ProteomicsDB; 86409; -. [Q9Y5I2-2]
DR ProteomicsDB; 86410; -. [Q9Y5I2-3]
DR Antibodypedia; 45503; 152 antibodies from 20 providers.
DR DNASU; 56139; -.
DR Ensembl; ENST00000307360.6; ENSP00000304234.5; ENSG00000250120.8. [Q9Y5I2-1]
DR Ensembl; ENST00000506939.6; ENSP00000421030.2; ENSG00000250120.8. [Q9Y5I2-2]
DR Ensembl; ENST00000562220.2; ENSP00000478748.1; ENSG00000250120.8. [Q9Y5I2-3]
DR GeneID; 56139; -.
DR KEGG; hsa:56139; -.
DR MANE-Select; ENST00000307360.6; ENSP00000304234.5; NM_018901.4; NP_061724.1.
DR UCSC; uc003lhw.4; human. [Q9Y5I2-1]
DR CTD; 56139; -.
DR DisGeNET; 56139; -.
DR GeneCards; PCDHA10; -.
DR HGNC; HGNC:8664; PCDHA10.
DR HPA; ENSG00000250120; Tissue enhanced (brain, pancreas).
DR MIM; 604966; gene.
DR MIM; 606316; gene.
DR neXtProt; NX_Q9Y5I2; -.
DR OpenTargets; ENSG00000250120; -.
DR PharmGKB; PA33010; -.
DR VEuPathDB; HostDB:ENSG00000250120; -.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000164036; -.
DR HOGENOM; CLU_006480_0_0_1; -.
DR InParanoid; Q9Y5I2; -.
DR OMA; VIWLNAT; -.
DR OrthoDB; 184745at2759; -.
DR PhylomeDB; Q9Y5I2; -.
DR TreeFam; TF332299; -.
DR PathwayCommons; Q9Y5I2; -.
DR SignaLink; Q9Y5I2; -.
DR SIGNOR; Q9Y5I2; -.
DR BioGRID-ORCS; 56139; 8 hits in 1024 CRISPR screens.
DR GenomeRNAi; 56139; -.
DR Pharos; Q9Y5I2; Tdark.
DR PRO; PR:Q9Y5I2; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q9Y5I2; protein.
DR Bgee; ENSG00000250120; Expressed in cortical plate and 90 other tissues.
DR ExpressionAtlas; Q9Y5I2; baseline and differential.
DR Genevisible; Q9Y5I2; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0007399; P:nervous system development; TAS:ProtInc.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR031904; Cadherin_CBD.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR Pfam; PF00028; Cadherin; 4.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF15974; Cadherin_tail; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; SSF49313; 6.
DR PROSITE; PS00232; CADHERIN_1; 5.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 2: Evidence at transcript level;
KW Alternative splicing; Calcium; Cell adhesion; Cell membrane; Glycoprotein;
KW Membrane; Reference proteome; Repeat; Secreted; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..948
FT /note="Protocadherin alpha-10"
FT /id="PRO_0000003902"
FT TOPO_DOM 29..695
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 696..716
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 717..948
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 29..132
FT /note="Cadherin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 133..241
FT /note="Cadherin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 242..349
FT /note="Cadherin 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 350..454
FT /note="Cadherin 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 455..564
FT /note="Cadherin 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 587..689
FT /note="Cadherin 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT REPEAT 732..735
FT /note="PXXP 1"
FT REPEAT 772..775
FT /note="PXXP 2"
FT REPEAT 797..800
FT /note="PXXP 3"
FT REPEAT 830..833
FT /note="PXXP 4"
FT REPEAT 871..874
FT /note="PXXP 5"
FT REPEAT 889..892
FT /note="PXXP 6"
FT REGION 732..892
FT /note="6 X 4 AA repeats of P-X-X-P"
FT REGION 783..804
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 827..948
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 786..800
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 857..871
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 896..910
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 933..948
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 256
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 264
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 547
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 534..796
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.2"
FT /id="VSP_000690"
FT VAR_SEQ 797..844
FT /note="PRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSAT ->
FT VGYYVFIFLLCFMNNIFSYRIFSNMYQNISFLSTFHLCLNISSDTFVI (in
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:10380929"
FT /id="VSP_000691"
FT VAR_SEQ 845..948
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:10380929"
FT /id="VSP_000692"
FT VARIANT 439
FT /note="S -> R (in dbSNP:rs251362)"
FT /evidence="ECO:0000269|Ref.2"
FT /id="VAR_048535"
FT VARIANT 585
FT /note="V -> G (in dbSNP:rs251364)"
FT /id="VAR_048536"
FT VARIANT 639
FT /note="T -> A (in dbSNP:rs630162)"
FT /id="VAR_048537"
SQ SEQUENCE 948 AA; 102875 MW; 8F3C734B05EF4FB8 CRC64;
MVSRCSCLGV QCLLLSLLLL AAWEVGSGQL HYSVYEEARH GTFVGRIAQD LGLELAELVQ
RLFRVASKRH GDLLEVNLQN GILFVNSRID REELCGRSVE CSIHLEVIVD RPLQVFHVDV
EVKDINDNPP RFSVTEQKLS IPESRLLDSR FPLEGASDAD VGENALLTYK LSPNEYFVLD
IINKKDKDKF PVLVLRKLLD REENPQLKLL LTATDGGKPE FTGSVSLLIL VLDANDNAPI
FDRPVYEVKM YENQVNQTLV IRLNASDSDE GINKEMMYSF SSLVPPTIRR KFWINERTGE
IKVNDAIDFE DSNTYEIHVD VTDKGNPPMV GHCTVLVELL DENDNSPEVI VTSLSLPVKE
DAQVGTVIAL ISVSDHDSGA NGQVTCSLTP HVPFKLVSTY KNYYSLVLDS ALDRERVSAY
ELVVTARDGG SPPLWATASV SVEVADVNDN APAFAQSEYT VFVKENNPPG CHIFTVSAWD
ADAQENALVS YSLVERRLGE RSLSSYVSVH AESGKVYALQ PLDHEELELL QFQVSARDGG
VPPLGSNLTL QVFVLDENDN APALLASPAG SAGGAVSELV LRSVVAGHVV AKVRAVDADS
GYNAWLSYEL QSAAVGARIP FRVGLYTGEI STTRALDETD SPRQRLLVLV KDHGEPSLTA
TATVLVSLVE GSQAPKASSR ASVGVAPEVA LVDVNVYLII AICAVSSLLV LTLLLYTALR
CSAAPTEGAC GPVKPTLVCS SAVGSWSYSQ QRRQRVCSGE GLPKADLMAF SPSLPPCPMV
DVDGEDQSIG GDHSRKPRQP NPDWRYSASL RAGMHSSVHL EEAGILRAGP GGPDQQWPTV
SSATPEPEAG EVSPPVGAGV NSNSWTFKYG PGNPKQSGPG ELPDKFIIPG SPAIISIRQE
PTNSQIDKSD FITFGKKEET KKKKKKKKGN KTQEKKEKGN STTDNSDQ
