PCDAA_MOUSE
ID PCDAA_MOUSE Reviewed; 946 AA.
AC Q91Y20;
DT 07-JAN-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Protocadherin alpha-10 {ECO:0000312|EMBL:AAK26046.1};
DE Short=PCDH-alpha-10;
DE Flags: Precursor;
GN Name=Pcdha10 {ECO:0000312|EMBL:AAK26046.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=11230163; DOI=10.1101/gr.167301;
RA Wu Q., Zhang T., Cheng J.-F., Kim Y., Grimwood J., Schmutz J., Dickson M.,
RA Noonan J.P., Zhang M.Q., Myers R.M., Maniatis T.;
RT "Comparative DNA sequence analysis of mouse and human protocadherin gene
RT clusters.";
RL Genome Res. 11:389-404(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Potential calcium-dependent cell-adhesion protein. May be
CC involved in the establishment and maintenance of specific neuronal
CC connections in the brain. {ECO:0000303|PubMed:11230163}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:11230163};
CC Single-pass type I membrane protein {ECO:0000303|PubMed:11230163}.
CC -!- MISCELLANEOUS: The protocadherins alpha are expressed from a single
CC gene cluster similarly to immunoglobulin and T-cell receptors. The N-
CC terminal region containing the 6 extracellular cadherin domains, unique
CC to each protocadherin alpha, is encoded by one of the large exons found
CC in tandem array within the gene cluster. The C-terminal region,
CC identical to all protocadherins alpha, is encoded by 3 shared exons.
CC {ECO:0000303|PubMed:11230163}.
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DR EMBL; AY013757; AAK26046.1; -; mRNA.
DR EMBL; AC020968; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC020972; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC020973; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS37778.1; -.
DR RefSeq; NP_034091.1; NM_009961.1.
DR AlphaFoldDB; Q91Y20; -.
DR SMR; Q91Y20; -.
DR IntAct; Q91Y20; 1.
DR MINT; Q91Y20; -.
DR GlyGen; Q91Y20; 2 sites.
DR iPTMnet; Q91Y20; -.
DR PhosphoSitePlus; Q91Y20; -.
DR PRIDE; Q91Y20; -.
DR ProteomicsDB; 289323; -.
DR DNASU; 12943; -.
DR Ensembl; ENSMUST00000115658; ENSMUSP00000111322; ENSMUSG00000007440.
DR GeneID; 12943; -.
DR KEGG; mmu:12943; -.
DR UCSC; uc008epf.2; mouse.
DR CTD; 56139; -.
DR MGI; MGI:1298408; Pcdha10.
DR VEuPathDB; HostDB:ENSMUSG00000007440; -.
DR GeneTree; ENSGT00940000163846; -.
DR HOGENOM; CLU_006480_0_0_1; -.
DR OMA; TEATFHI; -.
DR OrthoDB; 184745at2759; -.
DR BioGRID-ORCS; 12943; 3 hits in 37 CRISPR screens.
DR PRO; PR:Q91Y20; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q91Y20; protein.
DR Bgee; ENSMUSG00000007440; Expressed in ileal epithelium and 34 other tissues.
DR Genevisible; Q91Y20; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IDA:MGI.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR031904; Cadherin_CBD.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF15974; Cadherin_tail; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; SSF49313; 6.
DR PROSITE; PS00232; CADHERIN_1; 5.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 2: Evidence at transcript level;
KW Calcium; Cell adhesion; Cell membrane; Glycoprotein; Membrane;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..946
FT /note="Protocadherin alpha-10"
FT /evidence="ECO:0000255"
FT /id="PRO_0000431485"
FT TOPO_DOM 31..697
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 698..718
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 719..946
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT DOMAIN 31..134
FT /note="Cadherin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 135..243
FT /note="Cadherin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 244..351
FT /note="Cadherin 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 352..456
FT /note="Cadherin 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 457..566
FT /note="Cadherin 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 582..679
FT /note="Cadherin 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT REPEAT 734..737
FT /note="PXXP 1"
FT REPEAT 774..777
FT /note="PXXP 2"
FT REPEAT 795..798
FT /note="PXXP 3"
FT REPEAT 828..831
FT /note="PXXP 4"
FT REPEAT 869..872
FT /note="PXXP 5"
FT REPEAT 887..890
FT /note="PXXP 6"
FT REGION 734..890
FT /note="6 X 4 AA repeats of P-X-X-P"
FT REGION 826..852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 865..946
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 931..946
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 258
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 549
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 946 AA; 102057 MW; 08338F82633C8B26 CRC64;
MSCVAMKYCH ESWCLLLSLL LFAIWEPGSG QLRYSVPEEA KHGTFVGRIA QDLGLELTEL
VPRLFRVASK DRGDLLEVNL QNGILFVNSR IDREELCGRS AECSIHLEVI VDRPLQVFHV
EVEVRDINDN PPVFPTTEKN LFVSESRALD PHFSLEGASD ADIGTNALLT YRLSPSEYFS
LEVPTTDELV KPLQLVLKKP LDRERASELH LVVKATDGGK PELTGTLELH ITVLDANDNA
PAFDRAIYRV KLVENARNGT VVIRLNASDL DEGSNGQILY SFAADVSPKT EATFHIDSVS
GEIKVNGKID FEETNLWKIQ AEAVDKGSPP MFGHCTILIE VLDINDNAPK IIVTSLSLPV
QEDAPVGTVI ALISVMDPDS TVNGQVTCSL SPHVPFKLVS TFKNYYSLVL DSALDRETTA
DYKVVVTARD GGSPALWATA SVSVEVADVN DNAPAFAQSE YTVFVKENNP PGVHVFTVLA
MDADAQENAL VSYSLVERRV GERLLSSYVS VHAESGKVFA LQPLDHEELE LLQFQVTAKD
AGVPALGSNV TLQVFVLDEN DNAPTLLPHG AVGAGGAVSE LVPRSVGSGH VVAKVRAVDA
DSGYNAWLSY ELQFRAGSVR SPFRVGLYTG EISITRALDE ADAPRQRLLV LVKDHGEPAL
TATATVLVSL VESNQAPKAS SRVLGPAASE SSVVDVNVYL IIAICAVSSL LVLTLVLYTA
LRCSALPTEV TCGPGKPMLV CSSAVGSWSY SQQRRQRVCS GEGPPKTDLM AFSPSVPPGL
GSGDSGVQQE IFENPRQPNP DWRYSASLRA GMHSSVHLEE AGILRAGPGG PDQQWPTVSS
ATPEPEAGEV SPPVGAGVNS NSWTFKYGPG NPKQSGPGEL PDKFIIPGSP AIISIRQEPA
NNQIDKSDFI TFGKKEETKK KKKKKKGNKT QEKKEKGNST TDNSDQ
