PCDAA_PANTR
ID PCDAA_PANTR Reviewed; 948 AA.
AC Q5DRF4;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 29-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Protocadherin alpha-10;
DE Short=PCDH-alpha-10;
DE Flags: Precursor;
GN Name=PCDHA10;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2]
RP IDENTIFICATION.
RX PubMed=15744052; DOI=10.1534/genetics.104.037606;
RA Wu Q.;
RT "Comparative genomics and diversifying selection of the clustered
RT vertebrate protocadherin genes.";
RL Genetics 169:2179-2188(2005).
CC -!- FUNCTION: Potential calcium-dependent cell-adhesion protein. May be
CC involved in the establishment and maintenance of specific neuronal
CC connections in the brain.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
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DR AlphaFoldDB; Q5DRF4; -.
DR SMR; Q5DRF4; -.
DR STRING; 9598.ENSPTRP00000058232; -.
DR PaxDb; Q5DRF4; -.
DR eggNOG; KOG3594; Eukaryota.
DR InParanoid; Q5DRF4; -.
DR Proteomes; UP000002277; Unplaced.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR031904; Cadherin_CBD.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR Pfam; PF00028; Cadherin; 4.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF15974; Cadherin_tail; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; SSF49313; 6.
DR PROSITE; PS00232; CADHERIN_1; 5.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 3: Inferred from homology;
KW Calcium; Cell adhesion; Cell membrane; Glycoprotein; Membrane;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..948
FT /note="Protocadherin alpha-10"
FT /id="PRO_0000003903"
FT TOPO_DOM 29..695
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 696..716
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 717..948
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 29..132
FT /note="Cadherin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 133..241
FT /note="Cadherin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 242..349
FT /note="Cadherin 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 350..454
FT /note="Cadherin 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 455..564
FT /note="Cadherin 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 587..689
FT /note="Cadherin 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT REPEAT 732..735
FT /note="PXXP 1"
FT REPEAT 772..775
FT /note="PXXP 2"
FT REPEAT 797..800
FT /note="PXXP 3"
FT REPEAT 830..833
FT /note="PXXP 4"
FT REPEAT 871..874
FT /note="PXXP 5"
FT REPEAT 889..892
FT /note="PXXP 6"
FT REGION 732..892
FT /note="6 X 4 AA repeats of P-X-X-P"
FT REGION 783..804
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 827..948
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 786..800
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 857..871
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 933..948
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 256
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 264
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 547
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 948 AA; 102840 MW; 7AF8C09C29529565 CRC64;
MVSRCSCLGV QCLLLSLLLL AAWEVGSGQL HYSVYEEARH GTFVGRIAQD LGLELAELVP
RLFRVASKRH GDLLEVNLQN GILFVNSRID REELCGRSVE CSIHLEVIVD RPLQVFHVDV
EVKDINDNPP RFSVTEQKLS IPESRLLDSR FPLEGASDAD VGENALLTYK LSPNEYFVLD
IINKKDKDKF PVLVLRKLLD REENPQLKLL LTATDGGKPE FTGSVSLLIL VLDANDNAPI
FDRPVYEVKM YENQVNQTLV IRLNASDSDE GINKEMMYSF SSLVPPTIRR KFWINERTGE
IKVNDAIDFE DSNTYQIHVD VTDKGNPPMV GHCTVLVELL DENDNSPEVI VTSLSLPVKE
DAQVGTVIAL ISVSDHDSGA NGQVTCSLTP HVPFKLVSTY KNYYSLVLDS ALDRERVSAY
ELVVTARDGG SPPLWATASV SVEVADVNDN APAFAQPEYT VFVKENNPPG YHIFTVSAWD
ADAQENALVS YSLVERRLGE RSLSSYVSVH AQSGKVYALQ PLDHEELELL QFQVSARDGG
VPPLGSNLTL QVFVLDENDN APALLASPAG SAGGAVSELV LRSVGAGHVV AKVRAVDADS
GYNAWLSYEL QSAAVGARIP FRVGLYTGEI STTRALDEAD SPRQRLLVLV KDHGEPSLTA
TATVLVSLVE GSQAPKASSR ASVGVAPEVA LVDVNVYLII AICAVSSLLV LTLLLYTALR
CSAAPTEGAC GPVKPTLVCS STVGSWSYSQ QRRQRVCSGE GLPKADLMAF SPSLPPCPMV
DVDGEDQSIG GDHSRKPRQP NPDWRYSASL RAGMHSSVHL EEAGILRAGP GGPDQQWPTV
SSATPEPEAG EVSPPVGAGV NSNSWTFKYG PGNPKQSGPG ELPDKFIIPG SPAIISIRQE
PANSQIDKSD FITFGKKEET KKKKKKKKGN KTQEKKEKGN STTDNSDQ
