ID   PCDB4_PANTR             Reviewed;         795 AA.
AC   Q5DRD0;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Protocadherin beta-4;
DE            Short=PCDH-beta-4;
DE   Flags: Precursor;
GN   Name=PCDHB4;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=15744052; DOI=10.1534/genetics.104.037606;
RA   Wu Q.;
RT   "Comparative genomics and diversifying selection of the clustered
RT   vertebrate protocadherin genes.";
RL   Genetics 169:2179-2188(2005).
CC   -!- FUNCTION: Potential calcium-dependent cell-adhesion protein. May be
CC       involved in the establishment and maintenance of specific neuronal
CC       connections in the brain.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}.
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DR   RefSeq; NP_001013428.1; NM_001013410.3.
DR   AlphaFoldDB; Q5DRD0; -.
DR   SMR; Q5DRD0; -.
DR   STRING; 9598.ENSPTRP00000029633; -.
DR   PaxDb; Q5DRD0; -.
DR   PRIDE; Q5DRD0; -.
DR   GeneID; 471659; -.
DR   KEGG; ptr:471659; -.
DR   CTD; 56131; -.
DR   eggNOG; KOG3594; Eukaryota.
DR   HOGENOM; CLU_006480_3_0_1; -.
DR   InParanoid; Q5DRD0; -.
DR   OrthoDB; 300321at2759; -.
DR   TreeFam; TF332299; -.
DR   Proteomes; UP000002277; Unplaced.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR032455; Cadherin_C.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR013164; Cadherin_N.
DR   InterPro; IPR030729; PCDHB4.
DR   PANTHER; PTHR24028:SF55; PTHR24028:SF55; 1.
DR   Pfam; PF00028; Cadherin; 5.
DR   Pfam; PF08266; Cadherin_2; 1.
DR   Pfam; PF16492; Cadherin_C_2; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 5.
DR   SUPFAM; SSF49313; SSF49313; 6.
DR   PROSITE; PS00232; CADHERIN_1; 5.
DR   PROSITE; PS50268; CADHERIN_2; 5.
PE   3: Inferred from homology;
KW   Calcium; Cell adhesion; Cell membrane; Glycoprotein; Membrane;
KW   Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..795
FT                   /note="Protocadherin beta-4"
FT                   /id="PRO_0000003921"
FT   TOPO_DOM        28..689
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        690..710
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        711..795
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          34..132
FT                   /note="Cadherin 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          137..241
FT                   /note="Cadherin 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          246..346
FT                   /note="Cadherin 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          351..450
FT                   /note="Cadherin 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          455..560
FT                   /note="Cadherin 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          567..670
FT                   /note="Cadherin 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   CARBOHYD        183
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        417
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        566
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   795 AA;  87262 MW;  2A73204354B5DDA9 CRC64;
     MKKLGRIHPN RQVLAFILMV FLSQVRLEPI RYSVLEETES GSFVAHLTKD LGLGIGELAS
     RSARVLSDDD EQRLQLDRQT GDLLLREKLD REELCGPIEP CVLHFQVFLE MPVQFFQGEL
     LIQDINDHSP VFPEREVLLK ILENSQPGTL FPLLIAEDLD VGSNGLQKYT ISPNSHFHIL
     TRNHSEGKKY PDLVQDKPLD REEQPEFSLT LVALDGGSPP RSGTVMVRIL IMDINDNAPE
     FVHTPYGVQV LENSPLDSPI VRVLARDIDA GNFGSVSYGL FQASDEIKQT FSINEVTGEI
     LLKKKLDFEK IKSYHVEIEA TDGGGLSGKG TVVIEVVDVN DNPPELIISS LTSSIPENAP
     ETVVSIFRIR DRDSGENGKM ICSIPDNLPF ILKPTLKNFY TLVTERPLDR ETSAEYNITI
     TVTDLGTPRL KTQQSITVQV SDVNDNAPAF AQTSYTLFVR ENNSPALHIG SVSATDRDSG
     TNAQVTYSLL PPQDPHLPLS SLVSINADNG HLFALRSLDY EALQAFEFRV GASDRGSPAL
     SSEALVRVLV LDANDNSPFV LYPLQNGSAP CTELVPRAAE PGYLVTKVVA VDGDSGQNAW
     LSYQLLKATE PGLFGVWAHN GEVRTARLLS ERDAAKHRLV VLVKDNGEPP RSATATLHVL
     LVDGFSQPYL PLPEAAPAQS QADSLTVYLV VALASVSSLF LFSVLLFVAV RLCRRSRAAS
     VGRCSVPEGP FPGHLVDVSG TGTLSQSYQY EVCLTGDSGT GEFKFLKPIF PNLLVQDTGR
     EVKENPKFRN SLVFS