PCDB5_HUMAN
ID PCDB5_HUMAN Reviewed; 795 AA.
AC Q9Y5E4; Q549F4; Q9UFU9;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 23-FEB-2022, sequence version 2.
DT 03-AUG-2022, entry version 172.
DE RecName: Full=Protocadherin beta-5;
DE Short=PCDH-beta-5;
DE Flags: Precursor;
GN Name=PCDHB5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT SER-720.
RX PubMed=10380929; DOI=10.1016/s0092-8674(00)80789-8;
RA Wu Q., Maniatis T.;
RT "A striking organization of a large family of human neural cadherin-like
RT cell adhesion genes.";
RL Cell 97:779-790(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT SER-720.
RA Ding J.B., Yu L., Zhao S.Y.;
RT "Cloning and characterization of a new human cDNA homologous to Rattus
RT norvegicus protocadherin-3 (pcdh3).";
RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT SER-720.
RX PubMed=11322959; DOI=10.1016/s0014-5793(01)02372-9;
RA Vanhalst K., Kools P., Vanden Eynde E., van Roy F.;
RT "The human and murine protocadherin-beta one-exon gene families show high
RT evolutionary conservation, despite the difference in gene number.";
RL FEBS Lett. 495:120-125(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 95-795.
RC TISSUE=Uterus;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- FUNCTION: Potential calcium-dependent cell-adhesion protein. May be
CC involved in the establishment and maintenance of specific neuronal
CC connections in the brain.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
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DR EMBL; AF152498; AAD43759.1; -; mRNA.
DR EMBL; AF134474; AAP97251.1; -; mRNA.
DR EMBL; AF217753; AAK51620.1; -; mRNA.
DR EMBL; BC001186; AAH01186.1; -; mRNA.
DR EMBL; AL117449; CAB55933.1; -; mRNA.
DR CCDS; CCDS4247.1; -.
DR PIR; T17243; T17243.
DR RefSeq; NP_056484.2; NM_015669.4.
DR AlphaFoldDB; Q9Y5E4; -.
DR BioGRID; 117593; 56.
DR IntAct; Q9Y5E4; 9.
DR STRING; 9606.ENSP00000231134; -.
DR GlyConnect; 1683; 1 N-Linked glycan (1 site).
DR GlyGen; Q9Y5E4; 4 sites, 1 N-linked glycan (1 site).
DR iPTMnet; Q9Y5E4; -.
DR PhosphoSitePlus; Q9Y5E4; -.
DR BioMuta; PCDHB5; -.
DR DMDM; 13431375; -.
DR EPD; Q9Y5E4; -.
DR jPOST; Q9Y5E4; -.
DR MassIVE; Q9Y5E4; -.
DR PaxDb; Q9Y5E4; -.
DR PeptideAtlas; Q9Y5E4; -.
DR PRIDE; Q9Y5E4; -.
DR ProteomicsDB; 86343; -.
DR Antibodypedia; 2351; 108 antibodies from 19 providers.
DR DNASU; 26167; -.
DR Ensembl; ENST00000231134.8; ENSP00000231134.5; ENSG00000113209.9.
DR GeneID; 26167; -.
DR KEGG; hsa:26167; -.
DR MANE-Select; ENST00000231134.8; ENSP00000231134.5; NM_015669.5; NP_056484.2.
DR UCSC; uc003liq.5; human.
DR CTD; 26167; -.
DR GeneCards; PCDHB5; -.
DR HGNC; HGNC:8690; PCDHB5.
DR HPA; ENSG00000113209; Low tissue specificity.
DR MIM; 604967; gene.
DR MIM; 606331; gene.
DR neXtProt; NX_Q9Y5E4; -.
DR OpenTargets; ENSG00000113209; -.
DR PharmGKB; PA33039; -.
DR VEuPathDB; HostDB:ENSG00000113209; -.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000157793; -.
DR HOGENOM; CLU_006480_3_0_1; -.
DR InParanoid; Q9Y5E4; -.
DR OrthoDB; 300321at2759; -.
DR PhylomeDB; Q9Y5E4; -.
DR TreeFam; TF332299; -.
DR PathwayCommons; Q9Y5E4; -.
DR SignaLink; Q9Y5E4; -.
DR BioGRID-ORCS; 26167; 8 hits in 1029 CRISPR screens.
DR ChiTaRS; PCDHB5; human.
DR GeneWiki; PCDHB5; -.
DR GenomeRNAi; 26167; -.
DR Pharos; Q9Y5E4; Tdark.
DR PRO; PR:Q9Y5E4; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q9Y5E4; protein.
DR Bgee; ENSG00000113209; Expressed in sperm and 117 other tissues.
DR ExpressionAtlas; Q9Y5E4; baseline and differential.
DR Genevisible; Q9Y5E4; HS.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0016339; P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; NAS:UniProtKB.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; TAS:UniProtKB.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0007416; P:synapse assembly; TAS:UniProtKB.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR InterPro; IPR030730; PCDHB5/6/8.
DR PANTHER; PTHR24028:SF90; PTHR24028:SF90; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 5.
DR SUPFAM; SSF49313; SSF49313; 6.
DR PROSITE; PS00232; CADHERIN_1; 5.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 2: Evidence at transcript level;
KW Acetylation; Calcium; Cell adhesion; Cell membrane; Glycoprotein; Membrane;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..795
FT /note="Protocadherin beta-5"
FT /id="PRO_0000003922"
FT TOPO_DOM 31..689
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 690..710
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 711..795
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 35..133
FT /note="Cadherin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 138..242
FT /note="Cadherin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 247..346
FT /note="Cadherin 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 351..450
FT /note="Cadherin 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 455..560
FT /note="Cadherin 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 567..670
FT /note="Cadherin 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT MOD_RES 296
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y5E7"
FT CARBOHYD 169
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 417
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 435
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 566
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 156
FT /note="I -> T (in dbSNP:rs17096901)"
FT /id="VAR_033704"
FT VARIANT 720
FT /note="P -> S (in dbSNP:rs400562)"
FT /evidence="ECO:0000269|PubMed:10380929,
FT ECO:0000269|PubMed:11322959, ECO:0000269|Ref.2"
FT /id="VAR_048552"
SQ SEQUENCE 795 AA; 86433 MW; BB67435BC10958A8 CRC64;
METALAKTPQ KRQVMFLAIL LLLWEAGSEA VRYSIPEETE SGYSVANLAK DLGLGVGELA
TRGARMHYKG NKELLQLDIK TGNLLLYEKL DREVMCGATE PCILHFQLLL ENPVQFFQTD
LQLTDINDHA PEFPEKEMLL KIPESTQPGT VFPLKIAQDF DIGSNTVQNY TISPNSHFHV
ATHNRGDGRK YPELVLDKAL DREERPELSL TLTALDGGAP PRSGTTTIRI VVLDNNDNAP
EFLQSFYEVQ VPENSPLNSL VVVVSARDLD AGAYGSVAYA LFQGDEVTQP FVIDEKTAEI
RLKRALDFEA TPYYNVEIVA TDGGGLSGKC TVAIEVVDVN DNAPELTMST LSSPTPENAP
ETVVAVFSVS DPDSGDNGRM ICSIQNDLPF LLKPTLKNFY TLVTQRTLDR ESQAEYNITI
TVTDMGTPRL KTEHNITVLV SDVNDNAPAF TQTSYTLFVR ENNSPALHIG SVSATDRDSG
TNAQVTYSLL PPQNPHLRLA SLVSINADNG HLFALRSLDY EALQAFEFRV GATDRGSPAL
SSEALVRVLV LDANDNSPFV LYPLQNGSAP CTELVPRAAE PGYLVTKVVA VDGDSGQNAW
LSYQLLKATE PGLFSMWAHN GEVRTARLLS ERDAAKHRLV VLVKDNGEPP RSATATLHVL
LVDGFSQPYL PLPEAAPAQA QADSLTVYLV VALASVSSLF LFSVLLFVAV RLCRRSRAAP
VGRCSVPEGP FPGHLVDVSG TGTLSQSYHY EVCLTGDSGA GEFKFLKPII PNLLPQGAGE
EIGKTAAFRN SFGLN
