ID   PCDB7_PANTR             Reviewed;         793 AA.
AC   Q5DRC7;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Protocadherin beta-7;
DE            Short=PCDH-beta-7;
DE   Flags: Precursor;
GN   Name=PCDHB7;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=15744052; DOI=10.1534/genetics.104.037606;
RA   Wu Q.;
RT   "Comparative genomics and diversifying selection of the clustered
RT   vertebrate protocadherin genes.";
RL   Genetics 169:2179-2188(2005).
CC   -!- FUNCTION: Potential calcium-dependent cell-adhesion protein. May be
CC       involved in the establishment and maintenance of specific neuronal
CC       connections in the brain.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}.
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DR   AlphaFoldDB; Q5DRC7; -.
DR   SMR; Q5DRC7; -.
DR   STRING; 9598.ENSPTRP00000047957; -.
DR   PaxDb; Q5DRC7; -.
DR   eggNOG; KOG3594; Eukaryota.
DR   InParanoid; Q5DRC7; -.
DR   Proteomes; UP000002277; Unplaced.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR032455; Cadherin_C.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR013164; Cadherin_N.
DR   InterPro; IPR030741; PCDHB7.
DR   PANTHER; PTHR24028:SF69; PTHR24028:SF69; 1.
DR   Pfam; PF00028; Cadherin; 5.
DR   Pfam; PF08266; Cadherin_2; 1.
DR   Pfam; PF16492; Cadherin_C_2; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 5.
DR   SUPFAM; SSF49313; SSF49313; 6.
DR   PROSITE; PS00232; CADHERIN_1; 5.
DR   PROSITE; PS50268; CADHERIN_2; 5.
PE   3: Inferred from homology;
KW   Calcium; Cell adhesion; Cell membrane; Glycoprotein; Membrane;
KW   Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..793
FT                   /note="Protocadherin beta-7"
FT                   /id="PRO_0000003927"
FT   TOPO_DOM        27..688
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        689..709
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        710..793
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          35..133
FT                   /note="Cadherin 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          138..242
FT                   /note="Cadherin 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          247..347
FT                   /note="Cadherin 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          352..451
FT                   /note="Cadherin 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          456..561
FT                   /note="Cadherin 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          568..671
FT                   /note="Cadherin 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   CARBOHYD        169
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        418
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        436
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        567
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   793 AA;  86787 MW;  1CBB9A4E4CF605E7 CRC64;
     MEARVERAVQ KRQVLFLCVF LGMSWAGAEP LRYFVAEETE RGTFLTNLAK DLGLGVGELR
     ARGTRIVSDQ NMQILLLSSL TGDLLLNEKL DREELCGPRE PCVLPFQLLL EKPFQIFRAE
     LWVRDINDHA PVFLDREISL KILESTTPGA AFLLESAQDS DVGTNSLSNY TISPNAYFHI
     NVHDSGEGNI YPELVLNQVL DREEIPEFSL TLTALDGGSP PRSGTALVRI LVLDVNDNAP
     DFVRSLYKVQ VPENSPVGSM VVSVSARDLD TGSNGEIAYA FSYATERILK TFQINPTSGN
     LHLKAQLDYE AIQTYTLTIQ AKDGGGLSGK CTVVVDVTDI NDNRPELLLS SLTSPIAENS
     PETVVAVFRI RDRDSGNNGK TVCSIQDDLP FILKPSVENF YTLVSEKPLD RERNTEYNIT
     ITVTDLGTPR LKTEHNITVL VSDVNDNAPA FTQTSYTLFV RENNSPALPI GSVSATDRDS
     GTNAQVIYSL LPSQDPHLPL SSLVSINADN GHLFALRSLD YEALQAFEFR VGATDRSSPA
     LSSEALVHVL VLDANDNSPF VLYPLQNSSA PCTEPLPRAA EPGYLVTKVV AVDGDSGQNA
     WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKQRL VVLVKDNGEP PRSATATLHV
     LLVDGFSQPY LRLPEAAPDQ ANLLTVYLVV ALASVSSLFL LSVLLFVAVR LCRRSRAAPV
     GRCSVPEGPF PRHLVDLSGT GTLSQSYQYE VCLTGGSGTN EFKFLKPIIP NLLPQSTGRE
     VEENRPFQNN LGF