PCDBB_HUMAN
ID PCDBB_HUMAN Reviewed; 797 AA.
AC Q9Y5F2; B4DSF7; Q2M223;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 176.
DE RecName: Full=Protocadherin beta-11;
DE Short=PCDH-beta-11;
DE Flags: Precursor;
GN Name=PCDHB11;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=10380929; DOI=10.1016/s0092-8674(00)80789-8;
RA Wu Q., Maniatis T.;
RT "A striking organization of a large family of human neural cadherin-like
RT cell adhesion genes.";
RL Cell 97:779-790(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=11322959; DOI=10.1016/s0014-5793(01)02372-9;
RA Vanhalst K., Kools P., Vanden Eynde E., van Roy F.;
RT "The human and murine protocadherin-beta one-exon gene families show high
RT evolutionary conservation, despite the difference in gene number.";
RL FEBS Lett. 495:120-125(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Potential calcium-dependent cell-adhesion protein. May be
CC involved in the establishment and maintenance of specific neuronal
CC connections in the brain.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9Y5F2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9Y5F2-2; Sequence=VSP_055931;
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DR EMBL; AF152490; AAD43751.1; -; mRNA.
DR EMBL; AF217747; AAK51615.1; -; mRNA.
DR EMBL; AK299719; BAG61619.1; -; mRNA.
DR EMBL; AC005752; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC112132; AAI12133.1; -; mRNA.
DR EMBL; BC113611; AAI13612.1; -; mRNA.
DR CCDS; CCDS4253.1; -. [Q9Y5F2-1]
DR RefSeq; NP_061754.1; NM_018931.2. [Q9Y5F2-1]
DR AlphaFoldDB; Q9Y5F2; -.
DR SMR; Q9Y5F2; -.
DR BioGRID; 121065; 114.
DR IntAct; Q9Y5F2; 48.
DR STRING; 9606.ENSP00000346802; -.
DR GlyConnect; 1677; 1 N-Linked glycan (1 site).
DR GlyGen; Q9Y5F2; 6 sites, 1 N-linked glycan (1 site), 2 O-linked glycans (2 sites).
DR iPTMnet; Q9Y5F2; -.
DR PhosphoSitePlus; Q9Y5F2; -.
DR BioMuta; PCDHB11; -.
DR DMDM; 13431383; -.
DR jPOST; Q9Y5F2; -.
DR MassIVE; Q9Y5F2; -.
DR PaxDb; Q9Y5F2; -.
DR PeptideAtlas; Q9Y5F2; -.
DR PRIDE; Q9Y5F2; -.
DR ProteomicsDB; 5021; -.
DR ProteomicsDB; 86351; -. [Q9Y5F2-1]
DR Antibodypedia; 27222; 132 antibodies from 23 providers.
DR DNASU; 56125; -.
DR Ensembl; ENST00000354757.5; ENSP00000346802.3; ENSG00000197479.7. [Q9Y5F2-1]
DR Ensembl; ENST00000624887.1; ENSP00000485553.1; ENSG00000197479.7. [Q9Y5F2-2]
DR GeneID; 56125; -.
DR KEGG; hsa:56125; -.
DR MANE-Select; ENST00000354757.5; ENSP00000346802.3; NM_018931.3; NP_061754.1.
DR UCSC; uc003liy.4; human. [Q9Y5F2-1]
DR CTD; 56125; -.
DR GeneCards; PCDHB11; -.
DR HGNC; HGNC:8682; PCDHB11.
DR HPA; ENSG00000197479; Low tissue specificity.
DR MIM; 604967; gene.
DR MIM; 606337; gene.
DR neXtProt; NX_Q9Y5F2; -.
DR OpenTargets; ENSG00000197479; -.
DR PharmGKB; PA33027; -.
DR VEuPathDB; HostDB:ENSG00000197479; -.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000163201; -.
DR HOGENOM; CLU_006480_3_0_1; -.
DR InParanoid; Q9Y5F2; -.
DR OMA; QPFYEVK; -.
DR OrthoDB; 300321at2759; -.
DR PhylomeDB; Q9Y5F2; -.
DR TreeFam; TF332299; -.
DR PathwayCommons; Q9Y5F2; -.
DR SignaLink; Q9Y5F2; -.
DR BioGRID-ORCS; 56125; 4 hits in 1027 CRISPR screens.
DR GeneWiki; PCDHB11; -.
DR GenomeRNAi; 56125; -.
DR Pharos; Q9Y5F2; Tdark.
DR PRO; PR:Q9Y5F2; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q9Y5F2; protein.
DR Bgee; ENSG00000197479; Expressed in calcaneal tendon and 98 other tissues.
DR Genevisible; Q9Y5F2; HS.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0016339; P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; NAS:UniProtKB.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; TAS:UniProtKB.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0007399; P:nervous system development; TAS:ProtInc.
DR GO; GO:0007416; P:synapse assembly; TAS:UniProtKB.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR InterPro; IPR030734; PCDHB11/12.
DR PANTHER; PTHR24028:SF286; PTHR24028:SF286; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; SSF49313; 6.
DR PROSITE; PS00232; CADHERIN_1; 5.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 2: Evidence at transcript level;
KW Alternative splicing; Calcium; Cell adhesion; Cell membrane; Glycoprotein;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..797
FT /note="Protocadherin beta-11"
FT /id="PRO_0000003934"
FT TOPO_DOM 27..690
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 691..711
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 712..797
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 35..133
FT /note="Cadherin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 138..242
FT /note="Cadherin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 247..347
FT /note="Cadherin 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 352..451
FT /note="Cadherin 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 456..561
FT /note="Cadherin 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 568..671
FT /note="Cadherin 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT CARBOHYD 418
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 436
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 487
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 567
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..365
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055931"
FT VARIANT 4
FT /note="Q -> R (in dbSNP:rs3756323)"
FT /id="VAR_021881"
FT VARIANT 7
FT /note="R -> H (in dbSNP:rs917535)"
FT /id="VAR_048553"
FT VARIANT 528
FT /note="D -> E (in dbSNP:rs799834)"
FT /id="VAR_059188"
SQ SEQUENCE 797 AA; 87088 MW; 8FBA0DBCC2858504 CRC64;
MENQGTRTQQ IRQVLLLFVL LGMSQAGSET WSFSVAEEMQ SGSFVGNLAK DLGLKVRELS
SRGARVVSND KKQRLQLDIN TGDLLLSETL DREELCGSIE PCVLHLQVLM QNPTQFLQIE
LQVRDINDHS PIFSEKQMLL EIPENSPVGA VFLLESAKDL DVGINAVKSY TISPNSHFHI
KMRVIPDNRK YPELVLDKAL DYEELPELSF ILSALDGGSP PRSGTALVRV VVVDINDNSP
EFEQAFYEVK IRENSILGSL ILIVSAWDLD SGTNGEICYT FSHASEDIRK TFEINQKSGE
ITLRAPLDFE TIESYSIIIQ ATDGGGLFGK STVIIHVIDV NDNAPEITVS SITSPIPENT
PETVVMVFSI QDIDSGDNGR IVCSIPEDLP FVLKSSVENY YTLETERPLD RESTAEYNIT
ITVTDLGIPR LKTEHNTTVL VSDVNDNAPT FTQTSYTLFV RENNSPALHI GSVSATDRDS
GTNAQVNYSL LPPQDLHLPL ASLVSINTDN GHLFALRSLD YEALQAFDFR VGATDRGSPA
LSSEALVRVL VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA
WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKHRL VVLVKDNGEP PRSATATLQV
LLVDGFSQPY LPLPEAAPAQ AQADSLTVYL VVALASVSSL FLFSVLLFVA VRLCRRSRAA
SVGSCSVPKG PFPGHLVDVS GTGTLSQSYQ YEVCLTGGSE TNEFKFLKPV IPNIQAKGLG
KNSEENSTFR NSFGFNF
