PCDBD_HUMAN
ID PCDBD_HUMAN Reviewed; 798 AA.
AC Q9Y5F0; A8K9V6;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 177.
DE RecName: Full=Protocadherin beta-13;
DE Short=PCDH-beta-13;
DE Flags: Precursor;
GN Name=PCDHB13; ORFNames=UNQ332/PRO531;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10380929; DOI=10.1016/s0092-8674(00)80789-8;
RA Wu Q., Maniatis T.;
RT "A striking organization of a large family of human neural cadherin-like
RT cell adhesion genes.";
RL Cell 97:779-790(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11322959; DOI=10.1016/s0014-5793(01)02372-9;
RA Vanhalst K., Kools P., Vanden Eynde E., van Roy F.;
RT "The human and murine protocadherin-beta one-exon gene families show high
RT evolutionary conservation, despite the difference in gene number.";
RL FEBS Lett. 495:120-125(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung, and Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Potential calcium-dependent cell-adhesion protein. May be
CC involved in the establishment and maintenance of specific neuronal
CC connections in the brain.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
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DR EMBL; AF152492; AAD43753.1; -; mRNA.
DR EMBL; AF217745; AAK51613.1; -; mRNA.
DR EMBL; AY358427; AAQ88793.1; -; mRNA.
DR EMBL; AK292821; BAF85510.1; -; mRNA.
DR EMBL; BC033068; AAH33068.1; -; mRNA.
DR EMBL; BC051348; AAH51348.1; -; mRNA.
DR EMBL; BC071934; AAH71934.1; -; mRNA.
DR CCDS; CCDS4255.1; -.
DR RefSeq; NP_061756.1; NM_018933.3.
DR AlphaFoldDB; Q9Y5F0; -.
DR SMR; Q9Y5F0; -.
DR BioGRID; 121063; 6.
DR IntAct; Q9Y5F0; 1.
DR GlyGen; Q9Y5F0; 3 sites.
DR iPTMnet; Q9Y5F0; -.
DR PhosphoSitePlus; Q9Y5F0; -.
DR BioMuta; PCDHB13; -.
DR DMDM; 13431381; -.
DR EPD; Q9Y5F0; -.
DR MassIVE; Q9Y5F0; -.
DR MaxQB; Q9Y5F0; -.
DR PaxDb; Q9Y5F0; -.
DR PeptideAtlas; Q9Y5F0; -.
DR PRIDE; Q9Y5F0; -.
DR Antibodypedia; 27230; 118 antibodies from 18 providers.
DR DNASU; 56123; -.
DR Ensembl; ENST00000341948.6; ENSP00000345491.4; ENSG00000187372.11.
DR GeneID; 56123; -.
DR KEGG; hsa:56123; -.
DR MANE-Select; ENST00000341948.6; ENSP00000345491.4; NM_018933.4; NP_061756.1.
DR UCSC; uc003lja.3; human.
DR CTD; 56123; -.
DR DisGeNET; 56123; -.
DR GeneCards; PCDHB13; -.
DR HGNC; HGNC:8684; PCDHB13.
DR HPA; ENSG00000187372; Low tissue specificity.
DR MIM; 604967; gene.
DR MIM; 606339; gene.
DR neXtProt; NX_Q9Y5F0; -.
DR OpenTargets; ENSG00000187372; -.
DR PharmGKB; PA33029; -.
DR VEuPathDB; HostDB:ENSG00000187372; -.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000164011; -.
DR HOGENOM; CLU_006480_3_0_1; -.
DR InParanoid; Q9Y5F0; -.
DR OMA; IMEARDA; -.
DR OrthoDB; 300321at2759; -.
DR PhylomeDB; Q9Y5F0; -.
DR TreeFam; TF332299; -.
DR PathwayCommons; Q9Y5F0; -.
DR SignaLink; Q9Y5F0; -.
DR BioGRID-ORCS; 56123; 7 hits in 1030 CRISPR screens.
DR GeneWiki; PCDHB13; -.
DR GenomeRNAi; 56123; -.
DR Pharos; Q9Y5F0; Tdark.
DR PRO; PR:Q9Y5F0; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q9Y5F0; protein.
DR Bgee; ENSG00000187372; Expressed in buccal mucosa cell and 130 other tissues.
DR Genevisible; Q9Y5F0; HS.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0032391; C:photoreceptor connecting cilium; IEA:Ensembl.
DR GO; GO:0097381; C:photoreceptor disc membrane; IEA:Ensembl.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0016339; P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; NAS:UniProtKB.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; TAS:UniProtKB.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0007416; P:synapse assembly; TAS:UniProtKB.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; SSF49313; 5.
DR PROSITE; PS00232; CADHERIN_1; 5.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 2: Evidence at transcript level;
KW Calcium; Cell adhesion; Cell membrane; Glycoprotein; Membrane;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..798
FT /note="Protocadherin beta-13"
FT /id="PRO_0000003938"
FT TOPO_DOM 29..690
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 691..711
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 712..798
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 36..134
FT /note="Cadherin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 139..243
FT /note="Cadherin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 248..348
FT /note="Cadherin 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 353..451
FT /note="Cadherin 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 456..561
FT /note="Cadherin 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 568..671
FT /note="Cadherin 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT CARBOHYD 418
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 436
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 567
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 471
FT /note="R -> G (in dbSNP:rs2910329)"
FT /id="VAR_059189"
FT CONFLICT 705
FT /note="V -> E (in Ref. 4; BAF85510)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 798 AA; 87552 MW; 2A478554498B41A3 CRC64;
MEASGKLICR QRQVLFSFLL LGLSLAGAAE PRSYSVVEET EGSSFVTNLA KDLGLEQREF
SRRGVRVVSR GNKLHLQLNQ ETADLLLNEK LDREDLCGHT EPCVLRFQVL LESPFEFFQA
ELQVIDINDH SPVFLDKQML VKVSESSPPG TTFPLKNAED LDVGQNNIEN YIISPNSYFR
VLTRKRSDGR KYPELVLDKA LDREEEAELR LTLTALDGGS PPRSGTAQVY IEVLDVNDNA
PEFEQPFYRV QISEDSPVGF LVVKVSATDV DTGVNGEISY SLFQASEEIG KTFKINPLTG
EIELKKQLDF EKLQSYEVNI EARDAGTFSG KCTVLIQVID VNDHAPEVTM SAFTSPIPEN
APETVVALFS VSDLDSGENG KISCSIQEDL PFLLKSAENF YTLLTERPLD RESRAEYNIT
ITVTDLGTPM LITQLNMTVL IADVNDNAPA FTQTSYTLFV RENNSPALHI RSVSATDRDS
GTNAQVTYSL LPPQDPHLPL TSLVSINADN GHLFALRSLD YEALQGFQFR VGASDHGSPA
LSSEALVRVV VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA
WLSYQLLKAT ELGLFGVWAH NGEVRTARLL SERDAAKHRL VVLVKDNGEP PRSATATLHV
LLVDGFSQPY LPLPEAAPTQ AQADLLTVYL VVALASVSSL FLFSVLLFVA VRLCRRSRAA
SVGRCLVPEG PLPGHLVDMS GTRTLSQSYQ YEVCLAGGSG TNEFKFLKPI IPNFPPQCPG
KEIQGNSTFP NNFGFNIQ
