PCDBE_HUMAN
ID PCDBE_HUMAN Reviewed; 798 AA.
AC Q9Y5E9; B4DPE2; Q4FZA4; Q4KN11;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 173.
DE RecName: Full=Protocadherin beta-14;
DE Short=PCDH-beta-14;
DE Flags: Precursor;
GN Name=PCDHB14;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=10380929; DOI=10.1016/s0092-8674(00)80789-8;
RA Wu Q., Maniatis T.;
RT "A striking organization of a large family of human neural cadherin-like
RT cell adhesion genes.";
RL Cell 97:779-790(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=11322959; DOI=10.1016/s0014-5793(01)02372-9;
RA Vanhalst K., Kools P., Vanden Eynde E., van Roy F.;
RT "The human and murine protocadherin-beta one-exon gene families show high
RT evolutionary conservation, despite the difference in gene number.";
RL FEBS Lett. 495:120-125(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Kidney;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Potential calcium-dependent cell-adhesion protein. May be
CC involved in the establishment and maintenance of specific neuronal
CC connections in the brain.
CC -!- INTERACTION:
CC Q9Y5E9; Q9ULX6: AKAP8L; NbExp=3; IntAct=EBI-10329013, EBI-357530;
CC Q9Y5E9; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-10329013, EBI-5916454;
CC Q9Y5E9; P61978: HNRNPK; NbExp=6; IntAct=EBI-10329013, EBI-304185;
CC Q9Y5E9; P61978-2: HNRNPK; NbExp=3; IntAct=EBI-10329013, EBI-7060731;
CC Q9Y5E9; O43390-2: HNRNPR; NbExp=3; IntAct=EBI-10329013, EBI-12236340;
CC Q9Y5E9; O75525: KHDRBS3; NbExp=3; IntAct=EBI-10329013, EBI-722504;
CC Q9Y5E9; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-10329013, EBI-3044087;
CC Q9Y5E9; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-10329013, EBI-11522433;
CC Q9Y5E9; O43586: PSTPIP1; NbExp=6; IntAct=EBI-10329013, EBI-1050964;
CC Q9Y5E9; Q96QR8: PURB; NbExp=3; IntAct=EBI-10329013, EBI-2880222;
CC Q9Y5E9; P38159: RBMX; NbExp=3; IntAct=EBI-10329013, EBI-743526;
CC Q9Y5E9; P0DJD3: RBMY1A1; NbExp=3; IntAct=EBI-10329013, EBI-8638511;
CC Q9Y5E9; P0DJD3-2: RBMY1A1; NbExp=3; IntAct=EBI-10329013, EBI-11994018;
CC Q9Y5E9; Q15415: RBMY1J; NbExp=6; IntAct=EBI-10329013, EBI-8642021;
CC Q9Y5E9; P84103: SRSF3; NbExp=3; IntAct=EBI-10329013, EBI-372557;
CC Q9Y5E9; P62995: TRA2B; NbExp=3; IntAct=EBI-10329013, EBI-725485;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9Y5E9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9Y5E9-2; Sequence=VSP_055932;
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DR EMBL; AF152493; AAD43754.1; -; mRNA.
DR EMBL; AF217744; AAK51612.1; -; mRNA.
DR EMBL; AK298296; BAG60554.1; -; mRNA.
DR EMBL; AC005752; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC098144; AAH98144.1; -; mRNA.
DR EMBL; BC099728; AAH99728.1; -; mRNA.
DR CCDS; CCDS4256.1; -. [Q9Y5E9-1]
DR RefSeq; NP_061757.1; NM_018934.3. [Q9Y5E9-1]
DR AlphaFoldDB; Q9Y5E9; -.
DR SMR; Q9Y5E9; -.
DR BioGRID; 121062; 20.
DR IntAct; Q9Y5E9; 14.
DR STRING; 9606.ENSP00000239449; -.
DR GlyConnect; 1678; 1 N-Linked glycan (1 site).
DR GlyGen; Q9Y5E9; 6 sites, 1 N-linked glycan (1 site).
DR iPTMnet; Q9Y5E9; -.
DR PhosphoSitePlus; Q9Y5E9; -.
DR BioMuta; PCDHB14; -.
DR DMDM; 13431380; -.
DR EPD; Q9Y5E9; -.
DR jPOST; Q9Y5E9; -.
DR MassIVE; Q9Y5E9; -.
DR PaxDb; Q9Y5E9; -.
DR PeptideAtlas; Q9Y5E9; -.
DR PRIDE; Q9Y5E9; -.
DR ProteomicsDB; 4778; -.
DR ProteomicsDB; 86348; -. [Q9Y5E9-1]
DR Antibodypedia; 27242; 104 antibodies from 20 providers.
DR DNASU; 56122; -.
DR Ensembl; ENST00000239449.7; ENSP00000239449.4; ENSG00000120327.7. [Q9Y5E9-1]
DR Ensembl; ENST00000624896.1; ENSP00000485055.1; ENSG00000120327.7. [Q9Y5E9-2]
DR GeneID; 56122; -.
DR KEGG; hsa:56122; -.
DR MANE-Select; ENST00000239449.7; ENSP00000239449.4; NM_018934.4; NP_061757.1.
DR UCSC; uc003ljb.5; human. [Q9Y5E9-1]
DR CTD; 56122; -.
DR GeneCards; PCDHB14; -.
DR HGNC; HGNC:8685; PCDHB14.
DR HPA; ENSG00000120327; Low tissue specificity.
DR MIM; 604967; gene.
DR MIM; 606340; gene.
DR neXtProt; NX_Q9Y5E9; -.
DR OpenTargets; ENSG00000120327; -.
DR PharmGKB; PA33030; -.
DR VEuPathDB; HostDB:ENSG00000120327; -.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000163362; -.
DR HOGENOM; CLU_006480_3_0_1; -.
DR InParanoid; Q9Y5E9; -.
DR OMA; SWIVTIS; -.
DR OrthoDB; 300321at2759; -.
DR PhylomeDB; Q9Y5E9; -.
DR TreeFam; TF332299; -.
DR PathwayCommons; Q9Y5E9; -.
DR SignaLink; Q9Y5E9; -.
DR BioGRID-ORCS; 56122; 17 hits in 1029 CRISPR screens.
DR ChiTaRS; PCDHB14; human.
DR GeneWiki; PCDHB14; -.
DR GenomeRNAi; 56122; -.
DR Pharos; Q9Y5E9; Tdark.
DR PRO; PR:Q9Y5E9; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q9Y5E9; protein.
DR Bgee; ENSG00000120327; Expressed in cortical plate and 148 other tissues.
DR Genevisible; Q9Y5E9; HS.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0016339; P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; NAS:UniProtKB.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; TAS:UniProtKB.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0007416; P:synapse assembly; TAS:UniProtKB.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 5.
DR SUPFAM; SSF49313; SSF49313; 6.
DR PROSITE; PS00232; CADHERIN_1; 5.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 1: Evidence at protein level;
KW Alternative splicing; Calcium; Cell adhesion; Cell membrane;
KW Disulfide bond; Glycoprotein; Membrane; Reference proteome; Repeat; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..798
FT /note="Protocadherin beta-14"
FT /id="PRO_0000003940"
FT TOPO_DOM 27..686
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 687..711
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 712..798
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 35..133
FT /note="Cadherin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 138..242
FT /note="Cadherin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 247..347
FT /note="Cadherin 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 352..451
FT /note="Cadherin 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 456..561
FT /note="Cadherin 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 568..671
FT /note="Cadherin 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT CARBOHYD 169
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 359
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 418
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 436
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 487
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 567
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 96..102
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..153
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055932"
SQ SEQUENCE 798 AA; 87548 MW; 65151C1A423BB52E CRC64;
MEIRGALDLR KRQVLIFLVL LGLSRAGTES AHYSVAEETE IGSFVANLAR DLGLGVEELS
SREARVVSDD NKKYLHLDLL TGNLLLNEKL DRDELCGSTE PCVLHFQVVL ENPLQFFRFE
LCVKDINDHS PTFLDKEILI KISEGTTVGA TFLMESAQDL DVGSNSLQNY TISPNSHFYI
KIPDSSDRKI YPELVLDRAL DYEQEAELRL TLTAVDGGSP PKSGTTLVLI KVLDINDNAP
EFPQSLYEVQ VPEDRPLGSW IATISAKDLD AGNYGKISYT FFHASEDIRK TFEINPISGE
VNLRSPLDFE VIQSYTINIQ ATDGGGLSGK CTLLVKVMDI NDNPPEVTIS SITKRIPENA
SETLVALFSI LDQDSGDNGR MICSIQDNLP FFLKPTFKNF FTLVSEKALD RESQAEYNIT
ITVTDLGTPR LKTEYNITVL LSDVNDNAPT FTQTSYTLFV RENNSPALHI GSVSATDRDS
GTNAQVNYSL LPPQDRHLPL ASLVSINADN GHLFALRSLD YEALQEFEFR VGATDRGSPA
LSSEALVRVL VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA
WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKHRL VVLVKDNGEP PRSATATLHV
LLVDGFSQPY LPLPEAAPAQ AQADSLTVYL VVALASVSSL FLFSVLLFVA VRLCRRSRAA
SVGRCSVPEG PFPGHLVDVS GTGTLSQSYQ YEVCLTGGSG TNEFKFLKPI IPNFQVHDTG
RNMGEIENFR NSFGLNIQ
