PCDBI_MOUSE
ID PCDBI_MOUSE Reviewed; 792 AA.
AC Q91Y02;
DT 29-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Protocadherin beta-18;
DE Short=PCDH-beta-18;
DE Flags: Precursor;
GN Name=Pcdhb18;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=11230163; DOI=10.1101/gr.167301;
RA Wu Q., Zhang T., Cheng J.-F., Kim Y., Grimwood J., Schmutz J., Dickson M.,
RA Noonan J.P., Zhang M.Q., Myers R.M., Maniatis T.;
RT "Comparative DNA sequence analysis of mouse and human protocadherin gene
RT clusters.";
RL Genome Res. 11:389-404(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Potential calcium-dependent cell-adhesion protein.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AY013779; AAK26068.1; -; mRNA.
DR EMBL; AC020967; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466528; EDL10153.1; -; Genomic_DNA.
DR CCDS; CCDS29184.1; -.
DR RefSeq; NP_444373.1; NM_053143.2.
DR AlphaFoldDB; Q91Y02; -.
DR SMR; Q91Y02; -.
DR STRING; 10090.ENSMUSP00000052113; -.
DR GlyGen; Q91Y02; 3 sites.
DR iPTMnet; Q91Y02; -.
DR PhosphoSitePlus; Q91Y02; -.
DR PaxDb; Q91Y02; -.
DR PRIDE; Q91Y02; -.
DR ProteomicsDB; 289325; -.
DR DNASU; 93889; -.
DR Ensembl; ENSMUST00000055949; ENSMUSP00000052113; ENSMUSG00000048347.
DR GeneID; 93889; -.
DR KEGG; mmu:93889; -.
DR UCSC; uc008eqd.1; mouse.
DR CTD; 93889; -.
DR MGI; MGI:2136756; Pcdhb18.
DR VEuPathDB; HostDB:ENSMUSG00000048347; -.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000163508; -.
DR HOGENOM; CLU_006480_3_0_1; -.
DR InParanoid; Q91Y02; -.
DR OMA; NLNSFFH; -.
DR OrthoDB; 300321at2759; -.
DR PhylomeDB; Q91Y02; -.
DR TreeFam; TF332299; -.
DR BioGRID-ORCS; 93889; 3 hits in 72 CRISPR screens.
DR PRO; PR:Q91Y02; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q91Y02; protein.
DR Bgee; ENSMUSG00000048347; Expressed in cortical plate and 27 other tissues.
DR Genevisible; Q91Y02; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 5.
DR SUPFAM; SSF49313; SSF49313; 6.
DR PROSITE; PS00232; CADHERIN_1; 5.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 2: Evidence at transcript level;
KW Calcium; Cell adhesion; Cell membrane; Glycoprotein; Membrane;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..792
FT /note="Protocadherin beta-18"
FT /evidence="ECO:0000255"
FT /id="PRO_0000432743"
FT TRANSMEM 693..713
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 27..133
FT /note="Cadherin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 134..242
FT /note="Cadherin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 243..347
FT /note="Cadherin 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 348..451
FT /note="Cadherin 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 452..561
FT /note="Cadherin 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 568..676
FT /note="Cadherin 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT CARBOHYD 169
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 418
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 452
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 792 AA; 86959 MW; A1567D495D6E8A24 CRC64;
MAARGSCVSR QRQVLFLFLL GGLCLAGSEL GRYSVTEETE RGSFVANLAK DLGLGVEALA
AKRTRVVCDD NKQHLFLDSH TGDLLTNEKL DREKLCGPTE PCMLYFQILM DNPFQIYRAE
LRILDINDHS PIFQDKKMIL KILENTAVGT TFRLERAQDS DGGRNGIQNY TISPNTFFHI
TVHNSDEGMI YPELVLDKAL DWEGQPEFSL TLTALDGGSP PRSGTATIHI LVLDINDNAP
QFPQELYEIQ APENSPIGLV VIKVTGEDVD SGVNAEISYS FFDASEDIRA TFQINPFSGE
ITLKALLDYE FIKSYKLNVQ AVDGGGLSAR CTVLVRVLDV NDNAPELIMS SLVNEVVENS
PETVLAVFRI NDRDSGENGK MVCHIQENLP FLLKPSVDNF YILMTEGALD RESRAEYNIT
ITVSDLGTPR LTTQHTIRVQ VSDINDNAPA FNQTSYTLFV RENNSPAMHI GTISATDSDA
GSNAHITYSL LPTQDLQMTL TSLVSINADN GQLFAIKALD YEALQAFEFH VGATDRGSPE
LSSQALVRVV VLDDNDNAPF VLYPMQNASA PYTELLPRTA EPGYLVTKVV AVDRDSGQNA
WLSFQLLKAT EPGLFSVWAH NGEVRTTRLL SERDVPKHRL LLLVKDNGDP PRSASVTLQV
LLVDGFSQPY LPLPEVAHNP TQGEEDVLTL YLVIALASVS SLFLLSVLLF VGVRLCRRAR
AASLGGCSVP EGHFPGHLVD VSGTGTLSQN YQYEVCLMGG SSGTSDFKFL KSIYPEVHAY
SSQDNSDGNP TF
