PCDG5_HUMAN
ID PCDG5_HUMAN Reviewed; 931 AA.
AC Q9Y5G8; Q2M3F5; Q9Y5D2;
DT 24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Protocadherin gamma-A5;
DE Short=PCDH-gamma-A5;
DE Flags: Precursor;
GN Name=PCDHGA5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain;
RX PubMed=10380929; DOI=10.1016/s0092-8674(00)80789-8;
RA Wu Q., Maniatis T.;
RT "A striking organization of a large family of human neural cadherin-like
RT cell adhesion genes.";
RL Cell 97:779-790(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Potential calcium-dependent cell-adhesion protein. May be
CC involved in the establishment and maintenance of specific neuronal
CC connections in the brain.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9Y5G8-1; Sequence=Displayed;
CC Name=2; Synonyms=Short;
CC IsoId=Q9Y5G8-2; Sequence=VSP_008667, VSP_008668;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF152325; AAD43719.1; -; mRNA.
DR EMBL; AF152512; AAD43772.1; -; mRNA.
DR EMBL; CH471062; EAW61938.1; -; Genomic_DNA.
DR EMBL; BC104926; AAI04927.1; -; mRNA.
DR EMBL; BC113460; AAI13461.1; -; mRNA.
DR CCDS; CCDS54925.1; -. [Q9Y5G8-1]
DR CCDS; CCDS75333.1; -. [Q9Y5G8-2]
DR RefSeq; NP_061741.1; NM_018918.2. [Q9Y5G8-1]
DR RefSeq; NP_114443.1; NM_032054.1. [Q9Y5G8-2]
DR AlphaFoldDB; Q9Y5G8; -.
DR SMR; Q9Y5G8; -.
DR BioGRID; 121050; 62.
DR IntAct; Q9Y5G8; 51.
DR STRING; 9606.ENSP00000429834; -.
DR GlyGen; Q9Y5G8; 2 sites.
DR iPTMnet; Q9Y5G8; -.
DR PhosphoSitePlus; Q9Y5G8; -.
DR BioMuta; PCDHGA5; -.
DR DMDM; 37999838; -.
DR EPD; Q9Y5G8; -.
DR jPOST; Q9Y5G8; -.
DR MassIVE; Q9Y5G8; -.
DR MaxQB; Q9Y5G8; -.
DR PaxDb; Q9Y5G8; -.
DR PeptideAtlas; Q9Y5G8; -.
DR PRIDE; Q9Y5G8; -.
DR Antibodypedia; 57471; 99 antibodies from 17 providers.
DR DNASU; 56110; -.
DR Ensembl; ENST00000518069.2; ENSP00000429834.1; ENSG00000253485.3. [Q9Y5G8-1]
DR Ensembl; ENST00000611914.1; ENSP00000480337.1; ENSG00000253485.3. [Q9Y5G8-2]
DR GeneID; 56110; -.
DR KEGG; hsa:56110; -.
DR MANE-Select; ENST00000518069.2; ENSP00000429834.1; NM_018918.3; NP_061741.1.
DR UCSC; uc003lju.3; human. [Q9Y5G8-1]
DR CTD; 56110; -.
DR GeneCards; PCDHGA5; -.
DR HGNC; HGNC:8703; PCDHGA5.
DR HPA; ENSG00000253485; Tissue enhanced (brain).
DR MIM; 604968; gene.
DR MIM; 606292; gene.
DR neXtProt; NX_Q9Y5G8; -.
DR OpenTargets; ENSG00000253485; -.
DR PharmGKB; PA33051; -.
DR VEuPathDB; HostDB:ENSG00000253485; -.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000165041; -.
DR HOGENOM; CLU_006480_3_0_1; -.
DR InParanoid; Q9Y5G8; -.
DR OMA; LFTRSEY; -.
DR OrthoDB; 213724at2759; -.
DR PhylomeDB; Q9Y5G8; -.
DR TreeFam; TF332299; -.
DR PathwayCommons; Q9Y5G8; -.
DR SignaLink; Q9Y5G8; -.
DR SIGNOR; Q9Y5G8; -.
DR BioGRID-ORCS; 56110; 9 hits in 1016 CRISPR screens.
DR GenomeRNAi; 56110; -.
DR Pharos; Q9Y5G8; Tdark.
DR PRO; PR:Q9Y5G8; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q9Y5G8; protein.
DR Bgee; ENSG00000253485; Expressed in cortical plate and 101 other tissues.
DR Genevisible; Q9Y5G8; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR031904; Cadherin_CBD.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR Pfam; PF15974; Cadherin_tail; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; SSF49313; 6.
DR PROSITE; PS00232; CADHERIN_1; 5.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 2: Evidence at transcript level;
KW Alternative splicing; Calcium; Cell adhesion; Cell membrane; Glycoprotein;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..931
FT /note="Protocadherin gamma-A5"
FT /id="PRO_0000003956"
FT TOPO_DOM 30..692
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 693..713
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 714..931
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 30..133
FT /note="Cadherin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 134..242
FT /note="Cadherin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 243..347
FT /note="Cadherin 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 348..452
FT /note="Cadherin 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 453..562
FT /note="Cadherin 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 570..683
FT /note="Cadherin 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT REGION 800..840
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 901..931
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 811..840
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 419
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 545
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 808..813
FT /note="QAPPNT -> VSFLFR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10380929,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_008667"
FT VAR_SEQ 814..931
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10380929,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_008668"
SQ SEQUENCE 931 AA; 100935 MW; 65B854089A52A7AA CRC64;
MASPPRGWGC GELLLPFMLL GTLCEPGSGQ IRYSMPEELD KGSFVGNIAK DLGLEPQELA
ERGVRIVSRG RTQLFALNPR SGSLVTAGRI DREELCAQSP LCVVNFNILV ENKMKIYGVE
VEIIDINDNF PRFRDEELKV KVNENAAAGT RLVLPFARDA DVGVNSLRSY QLSSNLHFSL
DVVSGTDGQK YPELVLEQPL DREKETVHDL LLTALDGGDP VLSGTTHIRV TVLDANDNAP
LFTPSEYSVS VPENIPVGTR LLMLTATDPD EGINGKLTYS FRNEEEKISE TFQLDSNLGE
ISTLQSLDYE ESRFYLMEVV AQDGGALVAS AKVVVTVQDV NDNAPEVILT SLTSSISEDC
LPGTVIALFS VHDGDSGENG EIACSIPRNL PFKLEKSVDN YYHLLTTRDL DREETSDYNI
TLTVMDHGTP PLSTESHIPL KVADVNDNPP NFPQASYSTS VTENNPRGVS IFSVTAHDPD
SGDNARVTYS LAEDTFQGAP LSSYVSINSD TGVLYALRSF DYEQLRDLQL WVTASDSGNP
PLSSNVSLSL FVLDQNDNTP EILYPALPTD GSTGVELAPR SAEPGYLVTK VVAVDKDSGQ
NAWLSYRLLK ASEPGLFAVG LHTGEVRTAR ALLDRDALKQ SLVVAVEDHG QPPLSATFTV
TVAVADRIPD ILADLGSIKT PIDPEDLDLT LYLVVAVAAV SCVFLAFVIV LLVLRLRRWH
KSRLLQAEGS RLAGVPASHF VGVDGVRAFL QTYSHEVSLT ADSRKSHLIF PQPNYADTLL
SEESCEKSEP LLMSDKVDAN KEERRVQQAP PNTDWRFSQA QRPGTSGSQN GDDTGTWPNN
QFDTEMLQAM ILASASEAAD GSSTLGGGAG TMGLSARYGP QFTLQHVPDY RQNVYIPGSN
ATLTNAAGKR DGKAPAGGNG NKKKSGKKEK K
