PCDGB_HUMAN
ID PCDGB_HUMAN Reviewed; 935 AA.
AC Q9Y5H2; B7ZVY8; Q9Y5D8; Q9Y5D9;
DT 24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Protocadherin gamma-A11;
DE Short=PCDH-gamma-A11;
DE Flags: Precursor;
GN Name=PCDHGA11;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
RC TISSUE=Brain;
RX PubMed=10380929; DOI=10.1016/s0092-8674(00)80789-8;
RA Wu Q., Maniatis T.;
RT "A striking organization of a large family of human neural cadherin-like
RT cell adhesion genes.";
RL Cell 97:779-790(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Potential calcium-dependent cell-adhesion protein. May be
CC involved in the establishment and maintenance of specific neuronal
CC connections in the brain.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9Y5H2-1; Sequence=Displayed;
CC Name=2; Synonyms=Short;
CC IsoId=Q9Y5H2-2; Sequence=VSP_008680, VSP_008681;
CC Name=3;
CC IsoId=Q9Y5H2-3; Sequence=VSP_008679;
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DR EMBL; AF152320; AAD43714.1; -; mRNA.
DR EMBL; AF152505; AAD43766.1; -; mRNA.
DR EMBL; AF152504; AAD43765.1; -; mRNA.
DR EMBL; CH471062; EAW61934.1; -; Genomic_DNA.
DR EMBL; BC136781; AAI36782.1; -; mRNA.
DR EMBL; BC171774; AAI71774.1; -; mRNA.
DR CCDS; CCDS47294.1; -. [Q9Y5H2-1]
DR CCDS; CCDS54930.1; -. [Q9Y5H2-3]
DR CCDS; CCDS75345.1; -. [Q9Y5H2-2]
DR RefSeq; NP_061737.1; NM_018914.2. [Q9Y5H2-1]
DR RefSeq; NP_114480.1; NM_032091.1. [Q9Y5H2-2]
DR RefSeq; NP_114481.1; NM_032092.1. [Q9Y5H2-3]
DR AlphaFoldDB; Q9Y5H2; -.
DR SMR; Q9Y5H2; -.
DR BioGRID; 121045; 18.
DR IntAct; Q9Y5H2; 9.
DR STRING; 9606.ENSP00000381589; -.
DR GlyGen; Q9Y5H2; 5 sites.
DR iPTMnet; Q9Y5H2; -.
DR PhosphoSitePlus; Q9Y5H2; -.
DR BioMuta; PCDHGA11; -.
DR DMDM; 37999842; -.
DR jPOST; Q9Y5H2; -.
DR MassIVE; Q9Y5H2; -.
DR MaxQB; Q9Y5H2; -.
DR PaxDb; Q9Y5H2; -.
DR PeptideAtlas; Q9Y5H2; -.
DR PRIDE; Q9Y5H2; -.
DR ProteomicsDB; 86385; -. [Q9Y5H2-1]
DR ProteomicsDB; 86386; -. [Q9Y5H2-2]
DR ProteomicsDB; 86387; -. [Q9Y5H2-3]
DR Antibodypedia; 57509; 11 antibodies from 6 providers.
DR DNASU; 56105; -.
DR Ensembl; ENST00000398587.7; ENSP00000381589.2; ENSG00000253873.6. [Q9Y5H2-1]
DR Ensembl; ENST00000518882.2; ENSP00000428333.1; ENSG00000253873.6. [Q9Y5H2-3]
DR Ensembl; ENST00000622044.1; ENSP00000480917.1; ENSG00000253873.6. [Q9Y5H2-2]
DR GeneID; 56105; -.
DR KEGG; hsa:56105; -.
DR MANE-Select; ENST00000398587.7; ENSP00000381589.2; NM_018914.3; NP_061737.1.
DR UCSC; uc003lko.2; human. [Q9Y5H2-1]
DR CTD; 56105; -.
DR DisGeNET; 56105; -.
DR GeneCards; PCDHGA11; -.
DR HGNC; HGNC:8698; PCDHGA11.
DR HPA; ENSG00000253873; Tissue enhanced (brain).
DR MIM; 604968; gene.
DR MIM; 606298; gene.
DR neXtProt; NX_Q9Y5H2; -.
DR OpenTargets; ENSG00000253873; -.
DR PharmGKB; PA33046; -.
DR VEuPathDB; HostDB:ENSG00000253873; -.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000164062; -.
DR HOGENOM; CLU_006480_3_0_1; -.
DR InParanoid; Q9Y5H2; -.
DR OMA; TAVSCIF; -.
DR OrthoDB; 213724at2759; -.
DR PhylomeDB; Q9Y5H2; -.
DR TreeFam; TF332299; -.
DR PathwayCommons; Q9Y5H2; -.
DR SignaLink; Q9Y5H2; -.
DR SIGNOR; Q9Y5H2; -.
DR BioGRID-ORCS; 56105; 5 hits in 1013 CRISPR screens.
DR GeneWiki; PCDHGA11; -.
DR GenomeRNAi; 56105; -.
DR Pharos; Q9Y5H2; Tdark.
DR PRO; PR:Q9Y5H2; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q9Y5H2; protein.
DR Bgee; ENSG00000253873; Expressed in stromal cell of endometrium and 93 other tissues.
DR Genevisible; Q9Y5H2; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR031904; Cadherin_CBD.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR Pfam; PF00028; Cadherin; 4.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR Pfam; PF15974; Cadherin_tail; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; SSF49313; 6.
DR PROSITE; PS00232; CADHERIN_1; 5.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 2: Evidence at transcript level;
KW Alternative splicing; Calcium; Cell adhesion; Cell membrane; Glycoprotein;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..935
FT /note="Protocadherin gamma-A11"
FT /id="PRO_0000003968"
FT TOPO_DOM 30..693
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 694..714
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 715..935
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 30..134
FT /note="Cadherin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 135..243
FT /note="Cadherin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 244..348
FT /note="Cadherin 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 349..453
FT /note="Cadherin 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 454..563
FT /note="Cadherin 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 571..677
FT /note="Cadherin 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT REGION 805..844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 905..935
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 48
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 255
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 266
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 420
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 546
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 627..811
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:10380929"
FT /id="VSP_008679"
FT VAR_SEQ 812..837
FT /note="QAPPNTDWRFSQAQRPGTSGSQNGDD -> VRFISLPPNCWCLGTSLLRRCF
FT LSLL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10380929"
FT /id="VSP_008680"
FT VAR_SEQ 838..935
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10380929"
FT /id="VSP_008681"
FT VARIANT 104
FT /note="F -> L (in dbSNP:rs11167744)"
FT /id="VAR_033711"
SQ SEQUENCE 935 AA; 101543 MW; 51296C167D62480B CRC64;
MANRLQRGDR SRLLLLLCIF LGTLRGFRAR QIRYSVPEET EKGSFVGNIS KDLGLEPREL
AKRGVRIVSR GKTQLFAVNP RSGSLITAGR IDREELCETV SSCFLNMELL VEDTLKIYGV
EVEIIDINDN APSFQEDEVE IKVSEHAIPG ARFALPNARD PDVGVNSLQS YQLSPNNYFS
LQLRGRTDGA KNPELVLEGS LDREKEAAHL LLLTALDGGD PIRKGAVPIR VVVLDVNDHI
PMFTQSVYRV SVPENISSGT RVLMVNATDP DEGINGEVMY SFRNMESKAS EIFQLDSQTG
EVQVRGSLDF EKYRFYEMEI QGQDGGGLFT TTTMLITVVD VNDNAPEITI TSSINSILEN
SPPGTVIALL NVQDQDSGEN GQVSCFIPNH LPFKLEKTYG NYYKLITSRV LDRELVQSYN
ITLTATDQGS PPLSAETHVW LNVADDNDNP PVFPHSSYSA YIPENNPRGA SIFSVTALDP
DSKQNALVTY SLTDDTVQGV PLSSYVSINS NTGVLYALQS FDYEQFRDLE LRVIARDSGD
PPLSSNVSLS LFVLDQNDNA PEILYPALPT DGSTGVELAP RSAEPGYLVT KVVAVDKDSG
QNAWLSYRLL KASEPGLFAV GEHTGEVRTA RALLDRDALK QSLVVAVQDH GQPPLSATVT
LTVAVADSIP EVLADLGSLE SLANSETSDL SLYLVVAVAA VSCIFLVFVI VLLALRLWRW
HKSRLLQASE GGLAGMPTSH FVGVDGVQAF LQTYSHEVSL IADSQKSHLI FPQPNYGDTL
ISQESCEKSE PLLIAEDSAI ILGKCDPTSN QQAPPNTDWR FSQAQRPGTS GSQNGDDTGT
WPNNQFDTEM LQAMILASAS EAADGSSTLG GGAGTMGLSA RYGPQFTLQH VPDYRQNVYI
PGSNATLTNA AGKRDGKAPA GGNGNKKKSG KKEKK
