PCDGH_HUMAN
ID PCDGH_HUMAN Reviewed; 923 AA.
AC Q9Y5G0; Q52LK8; Q9Y5C6;
DT 24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Protocadherin gamma-B5;
DE Short=PCDH-gamma-B5;
DE Flags: Precursor;
GN Name=PCDHGB5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain;
RX PubMed=10380929; DOI=10.1016/s0092-8674(00)80789-8;
RA Wu Q., Maniatis T.;
RT "A striking organization of a large family of human neural cadherin-like
RT cell adhesion genes.";
RL Cell 97:779-790(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Potential calcium-dependent cell-adhesion protein. May be
CC involved in the establishment and maintenance of specific neuronal
CC connections in the brain.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9Y5G0-1; Sequence=Displayed;
CC Name=2; Synonyms=Short;
CC IsoId=Q9Y5G0-2; Sequence=VSP_008692, VSP_008693;
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DR EMBL; AF152334; AAD43728.1; -; mRNA.
DR EMBL; AF152521; AAD43781.1; -; mRNA.
DR EMBL; CH471062; EAW61948.1; -; Genomic_DNA.
DR EMBL; BC093877; AAH93877.1; -; mRNA.
DR EMBL; BC093879; AAH93879.1; -; mRNA.
DR CCDS; CCDS75339.1; -. [Q9Y5G0-1]
DR CCDS; CCDS75340.1; -. [Q9Y5G0-2]
DR RefSeq; NP_061748.1; NM_018925.2. [Q9Y5G0-1]
DR RefSeq; NP_115270.1; NM_032099.1. [Q9Y5G0-2]
DR AlphaFoldDB; Q9Y5G0; -.
DR SMR; Q9Y5G0; -.
DR BioGRID; 121041; 52.
DR IntAct; Q9Y5G0; 4.
DR MINT; Q9Y5G0; -.
DR STRING; 9606.ENSP00000478258; -.
DR GlyConnect; 1689; 4 N-Linked glycans (1 site).
DR GlyGen; Q9Y5G0; 2 sites, 3 N-linked glycans (1 site).
DR iPTMnet; Q9Y5G0; -.
DR PhosphoSitePlus; Q9Y5G0; -.
DR BioMuta; PCDHGB5; -.
DR DMDM; 37999830; -.
DR EPD; Q9Y5G0; -.
DR jPOST; Q9Y5G0; -.
DR MassIVE; Q9Y5G0; -.
DR MaxQB; Q9Y5G0; -.
DR PeptideAtlas; Q9Y5G0; -.
DR PRIDE; Q9Y5G0; -.
DR ProteomicsDB; 86361; -. [Q9Y5G0-1]
DR ProteomicsDB; 86362; -. [Q9Y5G0-2]
DR Antibodypedia; 72859; 35 antibodies from 11 providers.
DR DNASU; 56101; -.
DR Ensembl; ENST00000617380.2; ENSP00000478258.1; ENSG00000276547.2. [Q9Y5G0-1]
DR Ensembl; ENST00000621169.1; ENSP00000484888.1; ENSG00000276547.2. [Q9Y5G0-2]
DR GeneID; 56101; -.
DR KEGG; hsa:56101; -.
DR MANE-Select; ENST00000617380.2; ENSP00000478258.1; NM_018925.3; NP_061748.1.
DR UCSC; uc003lkf.3; human. [Q9Y5G0-1]
DR CTD; 56101; -.
DR GeneCards; PCDHGB5; -.
DR HGNC; HGNC:8712; PCDHGB5.
DR HPA; ENSG00000276547; Tissue enhanced (parathyroid).
DR MIM; 604968; gene.
DR MIM; 606302; gene.
DR neXtProt; NX_Q9Y5G0; -.
DR OpenTargets; ENSG00000276547; -.
DR PharmGKB; PA33060; -.
DR VEuPathDB; HostDB:ENSG00000276547; -.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000156683; -.
DR HOGENOM; CLU_006480_3_0_1; -.
DR InParanoid; Q9Y5G0; -.
DR OMA; IKIHDRD; -.
DR OrthoDB; 305110at2759; -.
DR PhylomeDB; Q9Y5G0; -.
DR PathwayCommons; Q9Y5G0; -.
DR SignaLink; Q9Y5G0; -.
DR SIGNOR; Q9Y5G0; -.
DR BioGRID-ORCS; 56101; 6 hits in 181 CRISPR screens.
DR GenomeRNAi; 56101; -.
DR Pharos; Q9Y5G0; Tdark.
DR PRO; PR:Q9Y5G0; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q9Y5G0; protein.
DR Bgee; ENSG00000276547; Expressed in cortical plate and 94 other tissues.
DR Genevisible; Q9Y5G0; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR031904; Cadherin_CBD.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR Pfam; PF15974; Cadherin_tail; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; SSF49313; 6.
DR PROSITE; PS00232; CADHERIN_1; 5.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 2: Evidence at transcript level;
KW Alternative splicing; Calcium; Cell adhesion; Cell membrane; Glycoprotein;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..923
FT /note="Protocadherin gamma-B5"
FT /id="PRO_0000003979"
FT TOPO_DOM 31..687
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 688..708
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 709..923
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 31..133
FT /note="Cadherin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 134..242
FT /note="Cadherin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 243..343
FT /note="Cadherin 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 344..448
FT /note="Cadherin 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 449..558
FT /note="Cadherin 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 566..671
FT /note="Cadherin 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT REGION 794..832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 893..923
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 415
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 541
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 800..818
FT /note="QAPPNTDWRFSQAQRPGTS -> VSFIYVYSFSLPTQFSVFT (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:10380929,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_008692"
FT VAR_SEQ 819..923
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10380929,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_008693"
FT VARIANT 188
FT /note="G -> S (in dbSNP:rs6867460)"
FT /id="VAR_048571"
SQ SEQUENCE 923 AA; 99875 MW; 2CC42DDF7D80CC60 CRC64;
MGSGAGELGR AERLPVLFLF LLSLFCPALC EQIRYRIPEE MPKGSVVGNL ATDLGFSVQE
LPTRKLRVSS EKPYFTVSAE SGELLVSSRL DREEICGKKP ACALEFEAVA ENPLNFYHVN
VEIEDINDHT PKFTQNSFEL QISESAQPGT RFILEVAEDA DIGLNSLQKY KLSLNPSFSL
IIKEKQDGSK YPELALEKTL DREQQSYHRL VLTALDGGHP PLSGTTELRI QVTDANDNPP
VFNRDVYRVS LRENVPPGTT VLQVSATDQD EGINSEITYS FYRTGQIFSL NSKSGEITTQ
KKLDFEETKE YSMVVEGRDG GGLVAQCTVE INIQDENDNS PEVTFHSLLE MILENAVPGT
LIALIKIHDQ DSGENGEVNC QLQGEVPFKI ISSSKNSYKL VTDGTLDREQ TPEYNVTITA
TDRGKPPLSS SISVILHIRD VNDNAPVFHQ ASYLVSVPEN NPPGASIAQV CASDLDLGLN
GQVSYSIMAS DLEPLALASY VSMSAQSGVV FAQRAFDYEQ LRTFELTLQA RDQGSPALSA
NVSLRVLVGD RNDNAPRVLY PALGPDGSAL FDMVPRAAEP GYLVTKVVAV DADSGHNAWL
SYHVLQASEP GLFSLGLRTG EVRTARALGD RDAARQRLLV AVRDGGQPPL SATATLHLVF
ADSLQEVLPD ITDRPVPSDP QAELQFYLVV ALALISVLFL LAVILAVALR LRRSSSPAAW
SCFQPGLCVK SGPVVPPNYS QGTLPYSYNL CVAHTGKTEF NFLKCSEQLS SGQDILCGDS
SGALFPLCNS SESTSHPELQ APPNTDWRFS QAQRPGTSGS QNGDDTGTWP NNQFDTEMLQ
AMILASASEA ADGSSTLGGG AGTMGLSARY GPQFTLQHVP DYRQNVYIPG SNATLTNAAG
KRDGKAPAGG NGNKKKSGKK EKK
