PCDGJ_HUMAN
ID PCDGJ_HUMAN Reviewed; 929 AA.
AC Q9Y5F8; Q9UN63;
DT 24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Protocadherin gamma-B7;
DE Short=PCDH-gamma-B7;
DE Flags: Precursor;
GN Name=PCDHGB7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain;
RX PubMed=10380929; DOI=10.1016/s0092-8674(00)80789-8;
RA Wu Q., Maniatis T.;
RT "A striking organization of a large family of human neural cadherin-like
RT cell adhesion genes.";
RL Cell 97:779-790(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Potential calcium-dependent cell-adhesion protein. May be
CC involved in the establishment and maintenance of specific neuronal
CC connections in the brain.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9Y5F8-1; Sequence=Displayed;
CC Name=2; Synonyms=Short;
CC IsoId=Q9Y5F8-2; Sequence=VSP_008696, VSP_008697;
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DR EMBL; AF152336; AAD43730.1; -; mRNA.
DR EMBL; AF152523; AAD43783.1; -; mRNA.
DR EMBL; BC051788; AAH51788.1; -; mRNA.
DR CCDS; CCDS47293.1; -. [Q9Y5F8-1]
DR CCDS; CCDS75344.1; -. [Q9Y5F8-2]
DR RefSeq; NP_061750.1; NM_018927.3. [Q9Y5F8-1]
DR RefSeq; NP_115272.1; NM_032101.2. [Q9Y5F8-2]
DR AlphaFoldDB; Q9Y5F8; -.
DR SMR; Q9Y5F8; -.
DR BioGRID; 121039; 4.
DR STRING; 9606.ENSP00000381594; -.
DR GlyConnect; 1690; 4 N-Linked glycans (1 site).
DR GlyGen; Q9Y5F8; 2 sites, 3 N-linked glycans (1 site).
DR iPTMnet; Q9Y5F8; -.
DR PhosphoSitePlus; Q9Y5F8; -.
DR BioMuta; PCDHGB7; -.
DR DMDM; 37999828; -.
DR EPD; Q9Y5F8; -.
DR jPOST; Q9Y5F8; -.
DR MassIVE; Q9Y5F8; -.
DR MaxQB; Q9Y5F8; -.
DR PaxDb; Q9Y5F8; -.
DR PeptideAtlas; Q9Y5F8; -.
DR PRIDE; Q9Y5F8; -.
DR ProteomicsDB; 86357; -. [Q9Y5F8-1]
DR ProteomicsDB; 86358; -. [Q9Y5F8-2]
DR Antibodypedia; 56135; 12 antibodies from 4 providers.
DR DNASU; 56099; -.
DR Ensembl; ENST00000398594.4; ENSP00000381594.3; ENSG00000254122.3. [Q9Y5F8-1]
DR Ensembl; ENST00000612073.1; ENSP00000479132.1; ENSG00000254122.3. [Q9Y5F8-2]
DR GeneID; 56099; -.
DR KEGG; hsa:56099; -.
DR MANE-Select; ENST00000398594.4; ENSP00000381594.3; NM_018927.4; NP_061750.1.
DR UCSC; uc003lkm.4; human. [Q9Y5F8-1]
DR CTD; 56099; -.
DR DisGeNET; 56099; -.
DR GeneCards; PCDHGB7; -.
DR HGNC; HGNC:8714; PCDHGB7.
DR HPA; ENSG00000254122; Low tissue specificity.
DR MIM; 604968; gene.
DR MIM; 606304; gene.
DR neXtProt; NX_Q9Y5F8; -.
DR OpenTargets; ENSG00000254122; -.
DR PharmGKB; PA33062; -.
DR VEuPathDB; HostDB:ENSG00000254122; -.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000164848; -.
DR HOGENOM; CLU_006480_3_0_1; -.
DR InParanoid; Q9Y5F8; -.
DR OMA; ICKERRI; -.
DR OrthoDB; 305110at2759; -.
DR PhylomeDB; Q9Y5F8; -.
DR TreeFam; TF332299; -.
DR PathwayCommons; Q9Y5F8; -.
DR SIGNOR; Q9Y5F8; -.
DR BioGRID-ORCS; 56099; 9 hits in 1020 CRISPR screens.
DR GeneWiki; PCDHGB7; -.
DR GenomeRNAi; 56099; -.
DR Pharos; Q9Y5F8; Tdark.
DR PRO; PR:Q9Y5F8; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q9Y5F8; protein.
DR Bgee; ENSG00000254122; Expressed in stromal cell of endometrium and 95 other tissues.
DR Genevisible; Q9Y5F8; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR031904; Cadherin_CBD.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR Pfam; PF15974; Cadherin_tail; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; SSF49313; 6.
DR PROSITE; PS00232; CADHERIN_1; 5.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 2: Evidence at transcript level;
KW Alternative splicing; Calcium; Cell adhesion; Cell membrane; Glycoprotein;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..929
FT /note="Protocadherin gamma-B7"
FT /id="PRO_0000003983"
FT TOPO_DOM 31..691
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 692..712
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 713..929
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 31..133
FT /note="Cadherin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 134..242
FT /note="Cadherin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 243..347
FT /note="Cadherin 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 348..452
FT /note="Cadherin 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 453..562
FT /note="Cadherin 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 570..675
FT /note="Cadherin 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT REGION 806..838
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 899..929
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 809..838
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 419
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 545
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 806..808
FT /note="QAP -> VSI (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10380929"
FT /id="VSP_008696"
FT VAR_SEQ 809..929
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10380929"
FT /id="VSP_008697"
FT VARIANT 405
FT /note="V -> L (in dbSNP:rs17208397)"
FT /id="VAR_048573"
SQ SEQUENCE 929 AA; 100974 MW; 2AFDD977CE501F59 CRC64;
MGGSCAQRRR AGPRQVLFPL LLPLFYPTLC EPIRYSIPEE LAKGSVVGNL AKDLGLSVLD
VSARELRVSA EKLHFSVDAQ SGDLLVKDRI DREQICKERR RCELQLEAVV ENPLNIFHVI
VVIEDVNDHA PQFRKDEINL EISESVSLGM GTILESAEDP DISMNSLSKY QLSPNEYFSL
VEKDNPDGGK YPELVLQKTL DRETQSAHHL VLTALDGGDP PRSGTAQIRI LVIDANDNPP
VFSQDVYRVS LREDVPPGTS ILRVKATDQD EGINSEITYS FFGVADKAQH VFSLDYTTGN
ILTQQPLDFE EVERYTINIE AKDRGSLSTR CKVIVEVVDE NDNSPEIIIT SLSDQIMEDS
PPGVVVALFK TRDQDSGENG EVRCSLSRGV PFKIHSSSNN YYKLVTDEAL DREQTPEYNV
TIAATDRGKP PLSSSKTITL HITDVNDNAP VFGQSAYLVH VPENNQPGAS IAQVSASDPD
FGLNGRVSYS LIASDLESRT LSSYVSVSAQ SGVVFAQRAF DHEQLRTFEL TLQARDQGSP
ALSANVSLRV LVGDRNDNAP RVLYPALGPD GSALFDTVPR AAQPGYLVTK VVAVDADSGH
NAWLSYHVVQ ASEPGLFSLG LRTGEVRMVR ALGDKDSVRQ RLLVAVRDGG QPPLSATATL
HLVFADSLQE VLPDFSDHPT PSDSQAEMQF YLVVALALIS VLFLLAVILA IALRLRQSFS
PTAGDCFESV LCSKSGPVGP PNYSEGTLPY AYNFCVPGDQ MNPEFNFFTS VDHCPATQDN
LNKDSMLLAS ILTPSVEADK KILKQQAPPN TDWRFSQAQR PGTSGSQNGD DTGTWPNNQF
DTEMLQAMIL ASASEAADGS STLGGGAGTM GLSARYGPQF TLQHVPDYRQ NVYIPGSNAT
LTNAAGKRDG KAPAGGNGNK KKSGKKEKK
