PCDGJ_PANTR
ID PCDGJ_PANTR Reviewed; 929 AA.
AC Q5DRA5;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 29-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Protocadherin gamma-B7;
DE Short=PCDH-gamma-B7;
DE Flags: Precursor;
GN Name=PCDHGB7;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2]
RP IDENTIFICATION.
RX PubMed=15744052; DOI=10.1534/genetics.104.037606;
RA Wu Q.;
RT "Comparative genomics and diversifying selection of the clustered
RT vertebrate protocadherin genes.";
RL Genetics 169:2179-2188(2005).
CC -!- FUNCTION: Potential calcium-dependent cell-adhesion protein. May be
CC involved in the establishment and maintenance of specific neuronal
CC connections in the brain.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
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DR RefSeq; NP_001076039.1; NM_001082570.2.
DR AlphaFoldDB; Q5DRA5; -.
DR SMR; Q5DRA5; -.
DR Ensembl; ENSPTRT00000061833; ENSPTRP00000054376; ENSPTRG00000017346.
DR GeneID; 100034692; -.
DR KEGG; ptr:100034692; -.
DR CTD; 56099; -.
DR GeneTree; ENSGT00940000162232; -.
DR InParanoid; Q5DRA5; -.
DR OrthoDB; 305110at2759; -.
DR Proteomes; UP000002277; Chromosome 5.
DR Bgee; ENSPTRG00000017346; Expressed in dorsolateral prefrontal cortex and 21 other tissues.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR031904; Cadherin_CBD.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR Pfam; PF15974; Cadherin_tail; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; SSF49313; 6.
DR PROSITE; PS00232; CADHERIN_1; 5.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 3: Inferred from homology;
KW Calcium; Cell adhesion; Cell membrane; Glycoprotein; Membrane;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..929
FT /note="Protocadherin gamma-B7"
FT /id="PRO_0000003984"
FT TOPO_DOM 31..691
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 692..712
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 713..929
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 31..133
FT /note="Cadherin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 134..242
FT /note="Cadherin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 243..347
FT /note="Cadherin 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 348..452
FT /note="Cadherin 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 453..562
FT /note="Cadherin 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 570..675
FT /note="Cadherin 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT REGION 806..838
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 899..929
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 809..838
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 419
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 545
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 929 AA; 100986 MW; 8D3C763DDD142ECA CRC64;
MGGSCAQRRR AGPRQVLFPL LLPLFYPTLC EPIRYSIPEE LAKGSVVGNL AKDLGLSVLD
VSARELRVSA EKLHFSVDAQ SGDLLVKDRI DREQICKERR RCELQLEAVV ENPLNIFHII
VVIEDVNDHA PQFQKDEINL EISESVSLGM GTILESAEDP DISMNSLSKY QLSPNEYFSL
VEKDNPDGGK YPELVLQKTL DRETQSAHHL VLTALDGGDP PRSGTAQIRI LVIDANDNPP
VFSQDVYRVS LREDVPPGTS ILRVKATDQD EGINSEITYS FFGVADKAQH VFSLDYTTGN
ILTQQPLDFE EVERYTMNIE AKDRGSLSTR CKVIVEVVDE NDNSPEIIIT SLSDQIMEDS
PPGVVVALFK TRDRDSGENG EVRCSLSRGV PFKIHSSSNN YYKLVTDEAL DREQTPEYNV
TIAATDRGKP PLSSSKTITL HITDVNDNAP VFGQSAYLVH VPENNQPGAS IAQVSASDPD
FGPNGRVSYS LIASDLESRT LSSYVSVSAQ SGVVFAQRAF DHEQLRTFEL TLQARDQGSP
ALSANVSLRV LVGDRNDNAP RVLYPALGPD GSALFDTVPR AAQPGYLVTK VVAVDADSGH
NAWLSYHVVQ ASEPGLFSLG LRTGEVRMVR ALGDKDLVRQ RLLVAVRDGG QPPLSATATL
HLVFADSLQE VLPDFSDHPT PSDSQAEMQF YLVVALALIS VLFLLAVILA IALRLRQSFS
PTAGDCFESV LCSKSGPVGP PNYSEGTLPY AYNFCVPGDQ MNPEFNFFAS VDHCPATQDN
LNKDSMLLAS ILTPSVEADK KILKQQAPPN TDWRFSQAQR PGTSGSQNGD DTGTWPNNQF
DTEMLQAMIL ASASEAADGS STLGGGAGTM GLSARYGPQF TLQHVPDYRQ NVYIPGSNAT
LTNAAGKRDG KAPAGGNGNK KKSGKKEKK
