PCDGM_HUMAN
ID PCDGM_HUMAN Reviewed; 944 AA.
AC Q9Y5F6; Q9Y5C2;
DT 24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Protocadherin gamma-C5;
DE Short=PCDH-gamma-C5;
DE Flags: Precursor;
GN Name=PCDHGC5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain;
RX PubMed=10380929; DOI=10.1016/s0092-8674(00)80789-8;
RA Wu Q., Maniatis T.;
RT "A striking organization of a large family of human neural cadherin-like
RT cell adhesion genes.";
RL Cell 97:779-790(1999).
CC -!- FUNCTION: Potential calcium-dependent cell-adhesion protein. May be
CC involved in the establishment and maintenance of specific neuronal
CC connections in the brain.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9Y5F6-1; Sequence=Displayed;
CC Name=2; Synonyms=Short;
CC IsoId=Q9Y5F6-2; Sequence=VSP_008702, VSP_008703;
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DR EMBL; AF152339; AAD43733.1; -; mRNA.
DR EMBL; AF152526; AAD43786.1; -; mRNA.
DR CCDS; CCDS4263.1; -. [Q9Y5F6-1]
DR CCDS; CCDS75350.1; -. [Q9Y5F6-2]
DR RefSeq; NP_061752.1; NM_018929.2. [Q9Y5F6-1]
DR RefSeq; NP_115783.1; NM_032407.1. [Q9Y5F6-2]
DR AlphaFoldDB; Q9Y5F6; -.
DR SMR; Q9Y5F6; -.
DR BioGRID; 121037; 21.
DR IntAct; Q9Y5F6; 2.
DR MINT; Q9Y5F6; -.
DR STRING; 9606.ENSP00000252087; -.
DR GlyGen; Q9Y5F6; 3 sites.
DR iPTMnet; Q9Y5F6; -.
DR PhosphoSitePlus; Q9Y5F6; -.
DR BioMuta; PCDHGC5; -.
DR DMDM; 37999826; -.
DR jPOST; Q9Y5F6; -.
DR MassIVE; Q9Y5F6; -.
DR MaxQB; Q9Y5F6; -.
DR PaxDb; Q9Y5F6; -.
DR PeptideAtlas; Q9Y5F6; -.
DR PRIDE; Q9Y5F6; -.
DR ProteomicsDB; 86353; -. [Q9Y5F6-1]
DR ProteomicsDB; 86354; -. [Q9Y5F6-2]
DR Antibodypedia; 35054; 238 antibodies from 17 providers.
DR DNASU; 56097; -.
DR Ensembl; ENST00000252087.3; ENSP00000252087.2; ENSG00000240764.4. [Q9Y5F6-1]
DR Ensembl; ENST00000610789.1; ENSP00000482569.1; ENSG00000240764.4. [Q9Y5F6-2]
DR GeneID; 56097; -.
DR KEGG; hsa:56097; -.
DR MANE-Select; ENST00000252087.3; ENSP00000252087.2; NM_018929.3; NP_061752.1.
DR UCSC; uc003lla.3; human. [Q9Y5F6-1]
DR CTD; 56097; -.
DR GeneCards; PCDHGC5; -.
DR HGNC; HGNC:8718; PCDHGC5.
DR HPA; ENSG00000240764; Tissue enriched (brain).
DR MIM; 604968; gene.
DR MIM; 606306; gene.
DR neXtProt; NX_Q9Y5F6; -.
DR OpenTargets; ENSG00000240764; -.
DR PharmGKB; PA33066; -.
DR VEuPathDB; HostDB:ENSG00000240764; -.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000162232; -.
DR HOGENOM; CLU_006480_0_0_1; -.
DR InParanoid; Q9Y5F6; -.
DR OMA; MLQIMVG; -.
DR OrthoDB; 385992at2759; -.
DR PhylomeDB; Q9Y5F6; -.
DR TreeFam; TF332299; -.
DR PathwayCommons; Q9Y5F6; -.
DR SignaLink; Q9Y5F6; -.
DR SIGNOR; Q9Y5F6; -.
DR BioGRID-ORCS; 56097; 12 hits in 1020 CRISPR screens.
DR GenomeRNAi; 56097; -.
DR Pharos; Q9Y5F6; Tdark.
DR PRO; PR:Q9Y5F6; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q9Y5F6; protein.
DR Bgee; ENSG00000240764; Expressed in prefrontal cortex and 87 other tissues.
DR Genevisible; Q9Y5F6; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR GO; GO:0050808; P:synapse organization; IEA:Ensembl.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR031904; Cadherin_CBD.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR Pfam; PF15974; Cadherin_tail; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; SSF49313; 6.
DR PROSITE; PS00232; CADHERIN_1; 5.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 2: Evidence at transcript level;
KW Alternative splicing; Calcium; Cell adhesion; Cell membrane; Glycoprotein;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..944
FT /note="Protocadherin gamma-C5"
FT /id="PRO_0000003989"
FT TOPO_DOM 30..693
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 694..714
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 715..944
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 30..133
FT /note="Cadherin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 134..242
FT /note="Cadherin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 243..350
FT /note="Cadherin 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 351..454
FT /note="Cadherin 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 455..564
FT /note="Cadherin 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 571..677
FT /note="Cadherin 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT REGION 722..747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 812..853
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 914..944
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 814..853
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 265
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 443
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 547
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 821..878
FT /note="QAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAA
FT DGSSTL -> VRGSAPPRATPGGGTGEAARPHKGLNLHPLLSGRLGRWLRSTRFSGSLD
FT RLRETRVAD (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10380929"
FT /id="VSP_008702"
FT VAR_SEQ 879..944
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10380929"
FT /id="VSP_008703"
FT VARIANT 275
FT /note="G -> S (in dbSNP:rs2233603)"
FT /id="VAR_048574"
FT VARIANT 570
FT /note="D -> G (in dbSNP:rs2074912)"
FT /id="VAR_024394"
SQ SEQUENCE 944 AA; 101921 MW; 10B8E7D60DC9497A CRC64;
MGPKTLPQLA GKWQVLCMLS LCCWGWVSGQ LRYSVVEESE PGTLVGNVAQ DLGLKMTDLL
SRRLQLGSEE NGRYFSLSLM SGALAVNQKI DRESLCGAST SCLLPVQVVT EHPLELIRVE
VEILDLNDNS PSFATPEREM RISESAASGA RFPLDSAQDP DVGTNTVSFY TLSPNSHFSL
NVKTLKDGKP FPELVLEQQL DREAQARHQL VLTAVDGGTP ARSGTTLISV IVLDINDNAP
TFQSSVLRVG IPENAPIGTL LLRLNATDPD EGTNGQLDYS FGDHTSEAVR NLFGLDPSSG
AIHVLGPIDF EESRFYEIHA RARDQGQPAM EGHCVIQVDV GDVNDNAPEV LLASLANPVL
ESTPVGTVVG LFNVRDRDSG RNGEVSLDIS PDLPFQIKPS ENHYSLLTSQ PLDREATSHY
IIELLASDAG SPSLHKHLTI RLNISDVNDN APRFNQQLYT AYILENRPPG SLLCTVAASD
PDTGDNARLT YSIVGNQVQG APASSFVYVN PEDGRIFAQR TFDYELLQML QIVVGVRDSG
SPPLHANTSL HVFVLDENDN APAVLHPRPD WEHSAPQRLP RSAPPGSLVT KVTAVDADAG
HNAWLSYSLL PQSTAPGLFL VSTHTGEVRT ARALLEDDSD TQQVVVLVRD NGDPSLSSTA
TVLLVLEDED PEEMPKSSDF LIHPPERSDL TLYLIVALAT VSLLSLVTFT FLSAKCLQGN
ADGDGGGGQC CRRQDSPSPD FYKQSSPNLQ VSSDGTLKYM EVTLRPTDSQ SHCYRTCFSP
ASDGSDFTFL RPLSVQQPTA LALEPDAIRS RSNTLRERSQ QAPPNTDWRF SQAQRPGTSG
SQNGDDTGTW PNNQFDTEML QAMILASASE AADGSSTLGG GAGTMGLSAR YGPQFTLQHV
PDYRQNVYIP GSNATLTNAA GKRDGKAPAG GNGNKKKSGK KEKK
