PCDL_ACRMI
ID PCDL_ACRMI Reviewed; 4467 AA.
AC B8V7Q1;
DT 09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT 09-JUL-2014, sequence version 1.
DT 23-FEB-2022, entry version 20.
DE RecName: Full=Protocadherin-like protein {ECO:0000303|PubMed:23765379};
DE Flags: Precursor;
OS Acropora millepora (Staghorn coral) (Heteropora millepora).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC Astrocoeniina; Acroporidae; Acropora.
OX NCBI_TaxID=45264;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=22490231; DOI=10.1111/j.1365-294x.2012.05554.x;
RA Moya A., Huisman L., Ball E.E., Hayward D.C., Grasso L.C., Chua C.M.,
RA Woo H.N., Gattuso J.P., Foret S., Miller D.J.;
RT "Whole transcriptome analysis of the coral Acropora millepora reveals
RT complex responses to CO(2)-driven acidification during the initiation of
RT calcification.";
RL Mol. Ecol. 21:2440-2454(2012).
RN [2] {ECO:0000305}
RP PROTEIN SEQUENCE OF 212-228; 528-540; 581-594; 612-623; 665-717; 999-1010;
RP 1087-1128; 1291-1300; 1394-1404; 1508-1518; 1719-1734; 2291-2302;
RP 2900-2914; 2943-2958; 3477-3487 AND 3912-3928, TISSUE SPECIFICITY, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=23765379; DOI=10.1093/molbev/mst109;
RA Ramos-Silva P., Kaandorp J., Huisman L., Marie B., Zanella-Cleon I.,
RA Guichard N., Miller D.J., Marin F.;
RT "The skeletal proteome of the coral Acropora millepora: the evolution of
RT calcification by co-option and domain shuffling.";
RL Mol. Biol. Evol. 30:2099-2112(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}. Note=Presence in the organic matrix of the
CC skeleton may be due to shedding of a soluble peptide. {ECO:0000255,
CC ECO:0000303|PubMed:23765379}.
CC -!- TISSUE SPECIFICITY: Component of the acid-insoluble organic matrix of
CC the aragonitic skeleton (at protein level).
CC {ECO:0000269|PubMed:23765379}.
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DR EMBL; JT011093; -; NOT_ANNOTATED_CDS; mRNA.
DR PRIDE; B8V7Q1; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd00110; LamG; 2.
DR Gene3D; 4.10.900.10; -; 1.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_cytoplasmic-dom.
DR InterPro; IPR027397; Catenin-bd_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR001791; Laminin_G.
DR Pfam; PF00028; Cadherin; 23.
DR Pfam; PF01049; Cadherin_C; 1.
DR Pfam; PF02210; Laminin_G_2; 2.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 31.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00282; LamG; 2.
DR SUPFAM; SSF49313; SSF49313; 30.
DR SUPFAM; SSF49899; SSF49899; 2.
DR PROSITE; PS00232; CADHERIN_1; 9.
DR PROSITE; PS50268; CADHERIN_2; 31.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 1: Evidence at protein level;
KW Calcium; Direct protein sequencing; Disulfide bond; EGF-like domain;
KW Membrane; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..4467
FT /note="Protocadherin-like protein"
FT /evidence="ECO:0000255"
FT /id="PRO_0000429552"
FT TOPO_DOM 23..4258
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 4259..4279
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 4280..4467
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 23..128
FT /note="Cadherin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 129..238
FT /note="Cadherin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 239..350
FT /note="Cadherin 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 351..455
FT /note="Cadherin 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 459..566
FT /note="Cadherin 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 567..664
FT /note="Cadherin 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 665..764
FT /note="Cadherin 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 765..884
FT /note="Cadherin 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 885..994
FT /note="Cadherin 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 1092..1197
FT /note="Cadherin 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 1290..1395
FT /note="Cadherin 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 1396..1499
FT /note="Cadherin 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 1495..1597
FT /note="Cadherin 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 1601..1701
FT /note="Cadherin 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 1793..1891
FT /note="Cadherin 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 1892..1992
FT /note="Cadherin 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 1993..2100
FT /note="Cadherin 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 2101..2202
FT /note="Cadherin 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 2203..2312
FT /note="Cadherin 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 2313..2423
FT /note="Cadherin 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 2425..2529
FT /note="Cadherin 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 2530..2639
FT /note="Cadherin 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 2640..2746
FT /note="Cadherin 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 2747..2849
FT /note="Cadherin 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 2850..2954
FT /note="Cadherin 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 2955..3062
FT /note="Cadherin 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 3063..3170
FT /note="Cadherin 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 3173..3288
FT /note="Cadherin 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 3551..3589
FT /note="EGF-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 3590..3788
FT /note="Laminin G-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT DOMAIN 3790..3824
FT /note="EGF-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 3842..4096
FT /note="Laminin G-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT DOMAIN 4206..4238
FT /note="EGF-like 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REGION 4089..4118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4423..4445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4089..4115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 3555..3567
FT /evidence="ECO:0000255"
FT DISULFID 3561..3577
FT /evidence="ECO:0000255"
FT DISULFID 3579..3588
FT /evidence="ECO:0000255"
FT DISULFID 3762..3788
FT /evidence="ECO:0000255"
FT DISULFID 3794..3803
FT /evidence="ECO:0000255"
FT DISULFID 3797..3812
FT /evidence="ECO:0000255"
FT DISULFID 3814..3823
FT /evidence="ECO:0000255"
FT DISULFID 4207..4218
FT /evidence="ECO:0000255"
FT DISULFID 4212..4226
FT /evidence="ECO:0000255"
FT DISULFID 4228..4237
FT /evidence="ECO:0000255"
SQ SEQUENCE 4467 AA; 488589 MW; 424AB248C66E6C08 CRC64;
MRGINAIVGF LLCFCLLHRI NTAVQFKQEI LEEGKSAGYV VLSLPLPPSN EIYTFFQAQD
SGSRDALLLF QISESGVIKT TKPITYEIGQ KNYYDLVAIR RQRGEKVGGI PTSIRIVIKD
TNNFSPTFPQ HLYYGRVKER SPDNTVVMGL ENCFAEDRDT GGIQSYSISS GNDKGYFKTS
MTTVNDRKFL VLKTTNVPIL IDTTPEINLT VRAYDGANSA TTGITVKIID ENDNSPVFEK
KSYATTVNED TPLLTSVLRV RATDKDLGTN GGVYYYLNGA QYFSVDAITG VIKVVRQLPD
QPRIVLDVKA TDRGTPSKTA SVQVTIDING IPDYPPPDSS NPGVNTVPVF QEESYTASVR
EDFPINAALL VIHAIDRDPP GRNRQIRYSL SSSGTFEIDQ FSGVVKLVGR LNYDSKKQYN
LFVRATDQAL TPLVASASLK VTVQEVDKNR NTPVFSPANP QQRMVSIKEN MPASTQVGSL
ITATDADGNQ GPDGQIAYSI FSGSGLPYFQ INKDTGRLET VIRLDRERQS QYDLIVEARD
KALYPLFSHV YLMINIDPEE DNNPDFSKVV YTANVPEKAP RDTFVTVIHA TDRDGASVSY
SIQNAGSAFA IRAETGVIVT ARVLDASIGD TDFTLFVTAS AGTKKSESQI NVTIVSKQDS
PPTFKNAPYS VTVPENLGKI DNLLCIAAYG VRGTAVSYSI ASAAVGKFAV DIDSGRFSAT
SSFDYEQVLG GEYPVQVQAS TSPQQVATAG ITVRVTDDKD PPTFSRSSYT FDIDENTPGG
TTILPKNADG SSGGLLISDE DTAITQFDCT IENVPGNVFD HFRVVNPDNS VRECKLVTVR
GFNFVENPSF QFEVRATDRN YRNMFASAQV KVVIKDTNNH SPEFSQTSYW ASVGRDYPTG
NSILKVTATD QDSGSFGEIT YELLNTQDRS RFSLDSNTGV LSFPNSLPAR RYQLRVQASD
RAQKSNEIRR TEVDVFVTVY LPGTGIIVFD PPLFPKAIRE DITINTQVKL VSTRGASNIK
YSIVGGNTNN AFRIGSNNGQ ILVQKALDRE TQSKYTLVIR AEESTSNVAT EANFIISVTD
VNDNPPRITF MEAQPKNIAI EDFSPPGSPV IRVIATDPDT GAAAAIKYSI TIGTPFSINE
DNGLITAARE IRKTERSTWD LTVTARDSGT PSRNSAPYRL RIHVTDGLQA PQLQPRFSVN
VNENEQVGNV VKDISPVQKN PNFKYSILSG NRDDAFCINH AGMISVAKPL DREKVNSYIL
RVSASVGNKI SNSTVSVTIA DQNDDAPQFS RTVYTFEVRE DLPQGREVGR VFAIDRDDGT
NGQVSYSLLY TVDVNSKFTV DGATGAVVTG SVLDFEEIRQ HILYVKAEDK GRPLRTSIAK
VIVNVKDVND RSPKFSADSY VTKVSLDEVI GTQVLLVSAT DLDSGDNSVV VYNITAGNEE
GAFEIDPDTG AIKVKKSLTT VSASKFSLRV EAKDKGNPPR MTPTTVQLNI FLPDGPPKFV
VKPVVEERFE GIAANGRVMV VKAATSEALT YEIISGNEDG LFRIEPTTGE IKVTRVLDYE
EASEHRLVVR VMDTRDRSDR VTVILKVKNI NDNEPQFPGE SNGFVERKVE DDFQIGDAAA
RLSAYDKDAG DSISYQLSAN ALPLFSIDNE GFLIAKKPRS EIQSPVKFEL VAKDNGVPQR
QTTVQVRLVF VSYRGDQQPV RVYVREDKEV GSVIARVPRF FPGGTLSIIF PQKANFTVDN
SGRIRMTTAF DFEQSQFYRL TVREQEPAPG RRTNDIDVEI NVVDVNDNKP KFTMIDFFGR
VNTNSRPGTS AYQLKAEDKD GGLSGTVGYQ MLSRDVPFGI NPISGVVETD ATLQDRGGYN
ITVFPFDFGV PREFGAAVSL DIKTVNFKPQ FSESAYRFQV FENAPPGVIV GEVNATSLSG
ARLGFSVPLG DPSKKFEVHN SGEIRLNSRL DHEKQSIYNL KVRATELIPG GYSNEVEVQV
TVTNANEYYP KFEPNLYFKV VNENVAAGQS VLRVTAIDKD CGTTSKCEAG LLKFSVEGTS
LFKIDPRTGD VSVGSTPLDY EKQREHVFTV VVEDFGEKIY KSRGFVTIDV RNTDDEKPQF
LESDYTISIA EDAETGRPLA AILARDADGD PVKYSITSGD SGGIFQINPT TGVLSLKSSI
KGNPRTQYTL QVKASNSAQD SRFDEVRVVV NIEDSNDNRP VFTDCPPEVP VEENKPRGHR
VYQVVAQDTK DRGRNKEIEY FLVTGGERLF EIDNTTGVIK TLTSLDRETK DQHTLIIMAE
DGGHGRNSAE RLLSYCILDV KVVDQNDNFP FFLTRTYYAS VWQGAPVNTE VLTVRAADMD
TRVNANIDNS EVQYQLVNAD DKFQVELATG VIKTKATLVS FVGKVQLQIR AINKQPMAIS
EERPRTSTTT VEINVEKDKP PAFAPSAVYK SAINEDVKIG KEVQQILAIS QVDRKNKIVY
SFVKSNPEGE QKFQIDPATG NITTASTLDY EQVKEYRLQF RATDIATNLY ATCVVIISLI
DVNDDTPTFK LEEYTARVPE NAAVDFNVIT IEADDRDTAL SGQVGYTLEV SDSSEGQFFA
INGQTGVMIT KKSFDREDPK HIPKYNVFAV ATDKGVPPLA AKVTISVAIV DQNDQPPIFP
KPSYEVSVQE DAGIGTSVGE FTATDADIGD NARLDYFISS GDASHIFKME SVYGDNNFGI
LILAGKLDFE TKKTYNISIT ATDRKDSATV PVVVNVLDTN DNIPKFDNLI YEAIIPENSP
PGQRVETVSA TDLDSPKIQN DLRYSLDADG QKNFAVDAVS GLITTANQRL DREVNPVVTF
TAFAFDGKHR GEALIRVTLR DVNDNSPYFP NPPYVGYVEE NLDPGASVMV IQAFDLDSGI
DGEIVYSLDD SSNNKFKIDR ISGLVTTVET MEKETAVNSF TIVVKATDKG SPALSGTVTA
TIRVSDGNDQ APVFNPREYR QKVPEDSPPG FLVTQVKATD QDEGYNAELE FTITAGNDPY
QFYIDPKTGE ILVSGMLDFD HGKKSYNLTV MVSDRGVPPK QAAKPAFVYI TIVDSNDNPP
VFVPAEYSIK VTEGTKPGDT VQLVTAVDQD TGTNALFTFG IADGDDADMF GIRPDPKNSS
IGFIYTVLQL DRETVPQYNL TVTATDTGGL QGVAVVRITV LDTNDNGPWF QPRYYEGSIT
VTSDSNSQQE ITTVKVFDPD EPSNGPPFSF SIESTKPATD ATRFGLRKDP KEPQTANEVY
SIGAFTRQVP EWELTIKAID SGKPVAMFNS TLVFVWVVDD KNLNEPFDGA LTIIVNAYDD
KFAGGIIGKA YYQDVDYMGD ENTYSMSEQE YFTLGELTGD ISAAANIPVG LYKFEIEVLE
QRLRPNTNTF KTVTSSVSVI VQSVPRAAIL QSVAVQILAY RRPALFVADI YTNFRQKLAG
IFGVQEADIL IFSVQRAPSK RVPLADVFGV EIQLAVRSSG SSFMDKMDVV RGIVEGKAEL
EALSLKIGDI GIDVCAAERQ DVGVCNNKVE ASSAFTVVSG DIGQIEPSKS SLTVVSIDIT
LKAVYTSILP PDINCTTGTP CLHGGTCHNA VPKGIICECG RDYLGPECQS TTRTFRGNSY
LWLDKLASYE RSSISLQFMT GSANGLLLYQ GPLYNGANNG LPDSIALYLV DGFAKLVIAL
GPHPMTPLEL YMNKGDRLDD RTWHTVQVIR ERKKVVLRID KCSYSKIVED YGQIVEDRSS
CEIKGEIWGS AIYLNGFGPL QIGGVENSIS DMKINFTGFS GCIRNIYNNG RMYDLFNPLK
EVNTELGCRL NNQCPNCNGR GYCEPFWNYA ICVCDLGFGG ANCDSRTQAN WYRANSFTQY
RVKQVKRKRR ELVPAPVSMA NEFYTNIALQ VRVSPNSSNV VIFLASNSLG TEFNRIDVKN
HVLRYAFRLG DRMKILKIPQ LNVTDDKYHT VIVKREGNRA SLQIDYRGKV EGTTGGLHKL
LNMGGGSFFT GGLPNITEVR VVEAFVNSGG NAVLRTAEGN IISSGMGSAY TGIGSYMSNV
ITVNNFGGVD VSYGVSGAPH VQRTIKTKSS IFTGSSGVIT RISVSRGHSV EFMNSRFFTR
KTKQKQKVII SSSGGSVSGG SGGASGGSGG ASGSGGSVGV SGGGGASVGG SILGSSASMD
TKGNLRSYGS GFGTWTIAGA GPNEAGDVQV IGDFGGCTAS NSYNGLDLDS HPTIEARRQN
VEFPCPCGSN FCRHGGTCVS ADPPYCLCPV GWSGPVCESI VKDPRPGQRP SSRWANPAVI
ACILVILLAI LVIIGAVLLK RRPQPAVVAV VEDGHVHDNV RPYHDEGAGE EDNFGYDIST
LMKYTYVENG VAGTGGVGHG KFKNGGSSGE EEFTATETKP LLQGAMPDDD LHFKTTTITK
RKVVHPDSID VKQFIDTRAS EADGEYILSI DELHIYRYEG DDSDVDDLSE LGDSDEEPDE
EEEQEFAFLQ DWGKKFDNLN RIFNEDE
