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PCEP4_ARATH
ID   PCEP4_ARATH             Reviewed;          86 AA.
AC   Q3EBM6;
DT   10-MAY-2017, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Precursor of CEP4 {ECO:0000303|PubMed:24179096};
DE            Short=PCEP4 {ECO:0000303|PubMed:24179096};
DE   Contains:
DE     RecName: Full=C-terminally encoded peptide 4 {ECO:0000303|PubMed:24179096};
DE              Short=CEP4 {ECO:0000303|PubMed:24179096};
DE   Flags: Precursor;
GN   Name=CEP4 {ECO:0000303|PubMed:24179096};
GN   OrderedLocusNames=At2g35612 {ECO:0000312|Araport:AT2G35612};
GN   ORFNames=T20F21 {ECO:0000305};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=18315543; DOI=10.1111/j.1365-313x.2008.03464.x;
RA   Ohyama K., Ogawa M., Matsubayashi Y.;
RT   "Identification of a biologically active, small, secreted peptide in
RT   Arabidopsis by in silico gene screening, followed by LC-MS-based structure
RT   analysis.";
RL   Plant J. 55:152-160(2008).
RN   [4]
RP   REVIEW.
RX   PubMed=22303274; DOI=10.1199/tab.0150;
RA   Matsubayashi Y.;
RT   "Small post-translationally modified Peptide signals in Arabidopsis.";
RL   Arabidopsis Book 9:E0150-E0150(2011).
RN   [5]
RP   TISSUE SPECIFICITY, AND GENE FAMILY.
RC   STRAIN=cv. Columbia;
RX   PubMed=24179095; DOI=10.1093/jxb/ert331;
RA   Roberts I., Smith S., De Rybel B., Van Den Broeke J., Smet W.,
RA   De Cokere S., Mispelaere M., De Smet I., Beeckman T.;
RT   "The CEP family in land plants: evolutionary analyses, expression studies,
RT   and role in Arabidopsis shoot development.";
RL   J. Exp. Bot. 64:5371-5381(2013).
RN   [6]
RP   FUNCTION, INDUCTION BY AMMONIUM CHLORIDE STARVATION; NITROGEN DEPLETION AND
RP   OSMOTIC STRESS, GENE FAMILY, AND NOMENCLATURE.
RC   STRAIN=cv. Columbia;
RX   PubMed=24179096; DOI=10.1093/jxb/ert332;
RA   Delay C., Imin N., Djordjevic M.A.;
RT   "CEP genes regulate root and shoot development in response to environmental
RT   cues and are specific to seed plants.";
RL   J. Exp. Bot. 64:5383-5394(2013).
RN   [7]
RP   FUNCTION.
RC   STRAIN=cv. No-0;
RX   PubMed=25324386; DOI=10.1126/science.1257800;
RA   Tabata R., Sumida K., Yoshii T., Ohyama K., Shinohara H., Matsubayashi Y.;
RT   "Perception of root-derived peptides by shoot LRR-RKs mediates systemic N-
RT   demand signaling.";
RL   Science 346:343-346(2014).
CC   -!- FUNCTION: Extracellular signaling peptide that represses primary root
CC       growth rate. Promotes shoot growth and modulates leaf morphology
CC       (PubMed:24179096). Regulates systemic nitrogen (N)-demand signaling.
CC       Mediates up-regulation of genes involved in N uptake and assimilation
CC       pathways (PubMed:25324386). {ECO:0000269|PubMed:24179096,
CC       ECO:0000269|PubMed:25324386}.
CC   -!- SUBUNIT: Interacts with CEP receptors (e.g. CEPR1 and CEPR2).
CC       {ECO:0000250|UniProtKB:Q8L8Y3}.
CC   -!- SUBCELLULAR LOCATION: [C-terminally encoded peptide 4]: Secreted,
CC       extracellular space, apoplast {ECO:0000250|UniProtKB:O80460}.
CC       Note=Accumulates in xylem sap. {ECO:0000250|UniProtKB:O80460}.
CC   -!- TISSUE SPECIFICITY: Expressed at low levels in flowers
CC       (PubMed:18315543). Present in lateral roots, shoot apical meristem
CC       (SAM), flowers and siliques (PubMed:24179095).
CC       {ECO:0000269|PubMed:18315543, ECO:0000269|PubMed:24179095}.
CC   -!- INDUCTION: Slightly induced in roots by nitrogen and ammonium chloride
CC       NH(4)Cl starvation. Accumulates in response to osmotic stress (e.g.
CC       mannitol and salt NaCl). {ECO:0000269|PubMed:24179096}.
CC   -!- PTM: The mature small signaling peptide is generated by proteolytic
CC       processing of the longer precursor. {ECO:0000250|UniProtKB:Q8L8Y3}.
CC   -!- SIMILARITY: Belongs to the C-terminally encoded plant signaling peptide
CC       (CEP) family. {ECO:0000305}.
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DR   EMBL; AC006068; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CP002685; AEC09129.1; -; Genomic_DNA.
DR   RefSeq; NP_001318359.1; NM_001336564.1.
DR   AlphaFoldDB; Q3EBM6; -.
DR   SMR; Q3EBM6; -.
DR   STRING; 3702.AT2G35612.1; -.
DR   PaxDb; Q3EBM6; -.
DR   PRIDE; Q3EBM6; -.
DR   EnsemblPlants; AT2G35612.1; AT2G35612.1; AT2G35612.
DR   GeneID; 28718329; -.
DR   Gramene; AT2G35612.1; AT2G35612.1; AT2G35612.
DR   KEGG; ath:AT2G35612; -.
DR   Araport; AT2G35612; -.
DR   TAIR; locus:1006230136; AT2G35612.
DR   eggNOG; KOG1186; Eukaryota.
DR   HOGENOM; CLU_2444970_0_0_1; -.
DR   InParanoid; Q3EBM6; -.
DR   OMA; LLVIQVH; -.
DR   OrthoDB; 1546836at2759; -.
DR   PhylomeDB; Q3EBM6; -.
DR   PRO; PR:Q3EBM6; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q3EBM6; baseline and differential.
DR   GO; GO:0048046; C:apoplast; ISS:UniProtKB.
DR   GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; ISS:UniProtKB.
DR   GO; GO:0006995; P:cellular response to nitrogen starvation; IEP:UniProtKB.
DR   GO; GO:1902025; P:nitrate import; IDA:UniProtKB.
DR   GO; GO:1901371; P:regulation of leaf morphogenesis; IMP:UniProtKB.
DR   GO; GO:2000280; P:regulation of root development; IMP:UniProtKB.
DR   GO; GO:0048831; P:regulation of shoot system development; IMP:UniProtKB.
DR   GO; GO:0060359; P:response to ammonium ion; IEP:UniProtKB.
DR   GO; GO:0006970; P:response to osmotic stress; IEP:UniProtKB.
DR   GO; GO:0009651; P:response to salt stress; IEP:UniProtKB.
DR   GO; GO:0048364; P:root development; IEA:InterPro.
DR   InterPro; IPR033250; CEP.
DR   PANTHER; PTHR33348; PTHR33348; 1.
PE   2: Evidence at transcript level;
KW   Apoplast; Developmental protein; Hormone; Hydroxylation;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   PROPEP          31..64
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000439971"
FT   PEPTIDE         65..79
FT                   /note="C-terminally encoded peptide 4"
FT                   /evidence="ECO:0000250|UniProtKB:Q058G9"
FT                   /id="PRO_0000439972"
FT   PROPEP          80..86
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000439973"
FT   REGION          63..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         68
FT                   /note="Hydroxyproline"
FT                   /evidence="ECO:0000250|UniProtKB:Q8L8Y3"
FT   MOD_RES         73
FT                   /note="Hydroxyproline"
FT                   /evidence="ECO:0000250|UniProtKB:Q058G9"
SQ   SEQUENCE   86 AA;  9755 MW;  CD56A4ABE059B44D CRC64;
     MVSRGCSITV LFRFLIVLLV IQVHFENTKA ARHAPVVSWS PPEPPKDDFV WYHKINRFKN
     IEQDAFRPTH QGPSQGIGHK NPPGAP
 
 
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