PCEP7_ARATH
ID PCEP7_ARATH Reviewed; 76 AA.
AC P0DN96;
DT 10-MAY-2017, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2017, sequence version 1.
DT 25-MAY-2022, entry version 17.
DE RecName: Full=Precursor of CEP7 {ECO:0000303|PubMed:24179096};
DE Short=PCEP7 {ECO:0000303|PubMed:24179096};
DE Contains:
DE RecName: Full=C-terminally encoded peptide 7 {ECO:0000303|PubMed:24179096};
DE Short=CEP7 {ECO:0000303|PubMed:24179096};
DE Flags: Precursor;
GN Name=CEP7 {ECO:0000303|PubMed:24179096};
GN OrderedLocusNames=At5g66818 {ECO:0000305}; ORFNames=MUD21 {ECO:0000305};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9679202; DOI=10.1093/dnares/5.2.131;
RA Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
RT features of the regions of 1,381,565 bp covered by twenty one physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:131-145(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY.
RC STRAIN=cv. Columbia;
RX PubMed=24179095; DOI=10.1093/jxb/ert331;
RA Roberts I., Smith S., De Rybel B., Van Den Broeke J., Smet W.,
RA De Cokere S., Mispelaere M., De Smet I., Beeckman T.;
RT "The CEP family in land plants: evolutionary analyses, expression studies,
RT and role in Arabidopsis shoot development.";
RL J. Exp. Bot. 64:5371-5381(2013).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=24179096; DOI=10.1093/jxb/ert332;
RA Delay C., Imin N., Djordjevic M.A.;
RT "CEP genes regulate root and shoot development in response to environmental
RT cues and are specific to seed plants.";
RL J. Exp. Bot. 64:5383-5394(2013).
RN [5]
RP FUNCTION, AND INDUCTION BY NITROGEN DEPLETION.
RC STRAIN=cv. No-0;
RX PubMed=25324386; DOI=10.1126/science.1257800;
RA Tabata R., Sumida K., Yoshii T., Ohyama K., Shinohara H., Matsubayashi Y.;
RT "Perception of root-derived peptides by shoot LRR-RKs mediates systemic N-
RT demand signaling.";
RL Science 346:343-346(2014).
CC -!- FUNCTION: Extracellular signaling peptide that may regulate primary
CC root growth rate and systemic nitrogen (N)-demand signaling (By
CC similarity). Mediates up-regulation of genes involved in N uptake and
CC assimilation pathways (PubMed:25324386). {ECO:0000250|UniProtKB:Q8L8Y3,
CC ECO:0000269|PubMed:25324386}.
CC -!- SUBUNIT: Interacts with CEP receptors (e.g. CEPR1 and CEPR2).
CC {ECO:0000250|UniProtKB:Q8L8Y3}.
CC -!- SUBCELLULAR LOCATION: [C-terminally encoded peptide 7]: Secreted,
CC extracellular space, apoplast {ECO:0000250|UniProtKB:O80460}.
CC Note=Accumulates in xylem sap. {ECO:0000250|UniProtKB:O80460}.
CC -!- INDUCTION: Triggered by nitrogen depletion.
CC {ECO:0000269|PubMed:25324386}.
CC -!- PTM: The mature small signaling peptide is generated by proteolytic
CC processing of the longer precursor. {ECO:0000250|UniProtKB:Q8L8Y3}.
CC -!- SIMILARITY: Belongs to the C-terminally encoded plant signaling peptide
CC (CEP) family. {ECO:0000305}.
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DR EMBL; AB010700; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002688; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; P0DN96; -.
DR SMR; P0DN96; -.
DR Araport; AT5G66818; -.
DR PRO; PR:P0DN96; -.
DR Proteomes; UP000006548; Chromosome 5.
DR GO; GO:0048046; C:apoplast; ISS:UniProtKB.
DR GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; ISS:UniProtKB.
DR GO; GO:0006995; P:cellular response to nitrogen starvation; IEP:UniProtKB.
DR GO; GO:1902025; P:nitrate import; IDA:UniProtKB.
DR GO; GO:1901371; P:regulation of leaf morphogenesis; IBA:GO_Central.
DR GO; GO:2000280; P:regulation of root development; ISS:UniProtKB.
DR GO; GO:0048364; P:root development; IEA:InterPro.
DR InterPro; IPR033250; CEP.
DR PANTHER; PTHR33348; PTHR33348; 1.
PE 2: Evidence at transcript level;
KW Apoplast; Developmental protein; Glycoprotein; Hormone; Hydroxylation;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT PROPEP 28..61
FT /evidence="ECO:0000305"
FT /id="PRO_0000439982"
FT PEPTIDE 62..76
FT /note="C-terminally encoded peptide 7"
FT /evidence="ECO:0000250|UniProtKB:Q058G9"
FT /id="PRO_0000439983"
FT REGION 49..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..66
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 65
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:Q8L8Y3"
FT MOD_RES 68
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:Q058G9"
FT MOD_RES 72
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:Q8L8Y3"
FT CARBOHYD 37
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 48
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 76 AA; 8125 MW; 92A654086B27A0FD CRC64;
MAKCTLTSLI LLLIVLVLIQ ESHIVEGRPL KSSRISNVSK KFAAGNSNLS SKLTTEDHSL
DAFRPTNPGN SPGIGH
