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PCEP8_ARATH
ID   PCEP8_ARATH             Reviewed;          87 AA.
AC   P0DN97;
DT   10-MAY-2017, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2017, sequence version 1.
DT   25-MAY-2022, entry version 14.
DE   RecName: Full=Precursor of CEP8 {ECO:0000303|PubMed:24179096};
DE            Short=PCEP8 {ECO:0000303|PubMed:24179096};
DE   Contains:
DE     RecName: Full=C-terminally encoded peptide 8 {ECO:0000303|PubMed:24179096};
DE              Short=CEP8 {ECO:0000303|PubMed:24179096};
DE   Flags: Precursor;
GN   Name=CEP8 {ECO:0000303|PubMed:24179096};
GN   OrderedLocusNames=At5g66819 {ECO:0000305}; ORFNames=MUD21 {ECO:0000305};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9679202; DOI=10.1093/dnares/5.2.131;
RA   Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
RT   features of the regions of 1,381,565 bp covered by twenty one physically
RT   assigned P1 and TAC clones.";
RL   DNA Res. 5:131-145(1998).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY.
RC   STRAIN=cv. Columbia;
RX   PubMed=24179095; DOI=10.1093/jxb/ert331;
RA   Roberts I., Smith S., De Rybel B., Van Den Broeke J., Smet W.,
RA   De Cokere S., Mispelaere M., De Smet I., Beeckman T.;
RT   "The CEP family in land plants: evolutionary analyses, expression studies,
RT   and role in Arabidopsis shoot development.";
RL   J. Exp. Bot. 64:5371-5381(2013).
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RC   STRAIN=cv. Columbia;
RX   PubMed=24179096; DOI=10.1093/jxb/ert332;
RA   Delay C., Imin N., Djordjevic M.A.;
RT   "CEP genes regulate root and shoot development in response to environmental
RT   cues and are specific to seed plants.";
RL   J. Exp. Bot. 64:5383-5394(2013).
RN   [5]
RP   TISSUE SPECIFICITY, FUNCTION, AND INDUCTION BY NITROGEN DEPLETION.
RC   STRAIN=cv. No-0;
RX   PubMed=25324386; DOI=10.1126/science.1257800;
RA   Tabata R., Sumida K., Yoshii T., Ohyama K., Shinohara H., Matsubayashi Y.;
RT   "Perception of root-derived peptides by shoot LRR-RKs mediates systemic N-
RT   demand signaling.";
RL   Science 346:343-346(2014).
CC   -!- FUNCTION: Extracellular signaling peptide that may regulate primary
CC       root growth rate and systemic nitrogen (N)-demand signaling (By
CC       similarity). Mediates up-regulation of genes involved in N uptake and
CC       assimilation pathways (PubMed:25324386). {ECO:0000250|UniProtKB:Q8L8Y3,
CC       ECO:0000269|PubMed:25324386}.
CC   -!- SUBUNIT: Interacts with CEP receptors (e.g. CEPR1 and CEPR2).
CC       {ECO:0000250|UniProtKB:Q8L8Y3}.
CC   -!- SUBCELLULAR LOCATION: [C-terminally encoded peptide 8]: Secreted,
CC       extracellular space, apoplast {ECO:0000250|UniProtKB:O80460}.
CC       Note=Accumulates in xylem sap. {ECO:0000250|UniProtKB:O80460}.
CC   -!- TISSUE SPECIFICITY: Expressed in lateral root primordia and in lateral
CC       roots excluding the meristem region. Also present in the aerial
CC       tissues, such as leaf petioles and the shoot apex region.
CC       {ECO:0000269|PubMed:25324386}.
CC   -!- INDUCTION: Triggered by nitrogen depletion.
CC       {ECO:0000269|PubMed:25324386}.
CC   -!- PTM: The mature small signaling peptide is generated by proteolytic
CC       processing of the longer precursor. {ECO:0000250|UniProtKB:Q8L8Y3}.
CC   -!- SIMILARITY: Belongs to the C-terminally encoded plant signaling peptide
CC       (CEP) family. {ECO:0000305}.
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DR   EMBL; AB010700; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CP002688; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; P0DN97; -.
DR   Araport; AT5G66819; -.
DR   PRO; PR:P0DN97; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   GO; GO:0048046; C:apoplast; ISS:UniProtKB.
DR   GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; ISS:UniProtKB.
DR   GO; GO:0006995; P:cellular response to nitrogen starvation; IEP:UniProtKB.
DR   GO; GO:1902025; P:nitrate import; IDA:UniProtKB.
DR   GO; GO:1901371; P:regulation of leaf morphogenesis; IBA:GO_Central.
DR   GO; GO:2000280; P:regulation of root development; ISS:UniProtKB.
DR   GO; GO:0048364; P:root development; IEA:InterPro.
DR   InterPro; IPR033250; CEP.
DR   PANTHER; PTHR33348; PTHR33348; 1.
PE   2: Evidence at transcript level;
KW   Apoplast; Developmental protein; Glycoprotein; Hormone; Hydroxylation;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   PROPEP          30..72
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000439984"
FT   PEPTIDE         73..87
FT                   /note="C-terminally encoded peptide 8"
FT                   /evidence="ECO:0000250|UniProtKB:Q058G9"
FT                   /id="PRO_0000439985"
FT   REGION          41..87
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         76
FT                   /note="Hydroxyproline"
FT                   /evidence="ECO:0000250|UniProtKB:Q8L8Y3"
FT   MOD_RES         79
FT                   /note="Hydroxyproline"
FT                   /evidence="ECO:0000250|UniProtKB:Q058G9"
FT   MOD_RES         83
FT                   /note="Hydroxyproline"
FT                   /evidence="ECO:0000250|UniProtKB:Q8L8Y3"
FT   CARBOHYD        41
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   87 AA;  9373 MW;  D9538888DE7B24C4 CRC64;
     MAKALFFNFC ISLLIIAILV SHEIIPTEAR HLRTHRKSIK NSTLTVHEGA GGLRTGGGSV
     KTDISKEEHG VDEFRPTTPG NSPGIGH
 
 
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