PCF11_CAEEL
ID PCF11_CAEEL Reviewed; 823 AA.
AC Q09345;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Polyadenylation and cleavage factor homolog 11;
GN Name=pcf-11; ORFNames=R144.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FO080694; CCD65870.1; -; Genomic_DNA.
DR PIR; T16758; T16758.
DR RefSeq; NP_498068.1; NM_065667.3.
DR AlphaFoldDB; Q09345; -.
DR SMR; Q09345; -.
DR BioGRID; 56599; 17.
DR IntAct; Q09345; 12.
DR STRING; 6239.R144.2a; -.
DR EPD; Q09345; -.
DR PaxDb; Q09345; -.
DR PeptideAtlas; Q09345; -.
DR EnsemblMetazoa; R144.2a.1; R144.2a.1; WBGene00020092.
DR EnsemblMetazoa; R144.2a.2; R144.2a.2; WBGene00020092.
DR GeneID; 246008; -.
DR KEGG; cel:CELE_R144.2; -.
DR UCSC; R144.2b; c. elegans.
DR CTD; 246008; -.
DR WormBase; R144.2a; CE02032; WBGene00020092; pcf-11.
DR eggNOG; KOG2071; Eukaryota.
DR HOGENOM; CLU_014705_0_0_1; -.
DR InParanoid; Q09345; -.
DR OMA; PANNRIF; -.
DR OrthoDB; 562928at2759; -.
DR PhylomeDB; Q09345; -.
DR Reactome; R-CEL-6807505; RNA polymerase II transcribes snRNA genes.
DR Reactome; R-CEL-72163; mRNA Splicing - Major Pathway.
DR Reactome; R-CEL-72187; mRNA 3'-end processing.
DR Reactome; R-CEL-73856; RNA Polymerase II Transcription Termination.
DR Reactome; R-CEL-77595; Processing of Intronless Pre-mRNAs.
DR SignaLink; Q09345; -.
DR PRO; PR:Q09345; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00020092; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR ExpressionAtlas; Q09345; baseline.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005849; C:mRNA cleavage factor complex; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0000993; F:RNA polymerase II complex binding; IBA:GO_Central.
DR GO; GO:0006379; P:mRNA cleavage; IEA:InterPro.
DR GO; GO:0006378; P:mRNA polyadenylation; IBA:GO_Central.
DR GO; GO:0006369; P:termination of RNA polymerase II transcription; IBA:GO_Central.
DR Gene3D; 1.25.40.90; -; 1.
DR InterPro; IPR006569; CID_dom.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR045154; PCF11-like.
DR PANTHER; PTHR15921; PTHR15921; 1.
DR Pfam; PF04818; CID; 1.
DR SMART; SM00582; RPR; 1.
DR SUPFAM; SSF48464; SSF48464; 1.
DR PROSITE; PS51391; CID; 1.
PE 4: Predicted;
KW Reference proteome.
FT CHAIN 1..823
FT /note="Polyadenylation and cleavage factor homolog 11"
FT /id="PRO_0000065440"
FT DOMAIN 3..135
FT /note="CID"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00724"
FT REGION 142..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 188..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 340..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 570..643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 728..755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..225
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..360
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..393
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 578..592
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 602..624
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 823 AA; 91142 MW; 18654DB4740FC06A CRC64;
MESVESAARD YRETLAELRN NNKTQINLLT ILADDFKKAA PQIVEVIERH LTTCSPSQKL
LVMYVCDSIL KNVKKPNDYD ALFARKIVSM FEHAFRQGDE RIRTSLYRIR VTWASTTLFM
PSKLYELDMK INKLDPNWPI SNPQTGRALR DDPQVMAPSQ SRPAGNATSP AASTSTNRVF
VNPKFIGSST PGAASASKTV VEKTKSPGTV NKEKQVKKEP KQDPLDKLLP SSSASKTSSS
PAGLKRKSAP SEHPNAPIRK KPQQPPKPQT AIDEDLRSIS LTKKPPVPSA QDQDFRPKTL
KPTSVIGSHA FAPVAAPIRP MIPVPPPVSV APFVPAPPLS SAPPFQHPQQ HHPQLPPPPV
HQGMGRGYHH NSPPQDPAPI VPVQAPPPQQ HLPAPENVYS SEQPKLDVPA NNRIFVDGKA
YEVMFVDDTA VIERGGAPHR IYFAGPPRNL VIDGIPHLLQ FDTPTQIDIL GSKHMVKFGA
PSRELYIGGH PFKGQFGGPP IIATINGRRH EIRLTGSAPE VRIEPEPAYH LTHFLHKMRE
EKKIEIASEK PEKKEDWLSY LKNLRTRNIL PAPARSPSSP RNQTPPPANL PIPGMNNAGQ
RGGYHNRHQP QQNARWGGAN KQQNIPPPPS DPSPIGSGVE KRSAPPAAIT DFNIRLLQIR
YDSVVDALIT KRADACKFCG MRLDDSQGKS KEWQDHMDWH VKQNLARHGS NNSAAVPYRQ
WYPSTSTWLT PRASDETNEQ EADKPEEPLP GVASSGVKTK ECSVCGEKFD EYYDDDEETW
RLRDTVNVHG KIVHSACASD AARSLDNSSF FNDSDIKKEE PFD
