ID   PCF5B_DANRE             Reviewed;         232 AA.
AC   Q1JPS1;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Polycomb group RING finger protein 5-B;
GN   Name=pcgf5b; ORFNames=zgc:136815;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of Polycomb group (PcG) multiprotein complexes; the
CC       complex class is required to maintain the transcriptionally repressive
CC       state of some genes. {ECO:0000250}.
CC   -!- SUBUNIT: Component of a PRC1-like complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; BC116619; AAI16620.1; -; mRNA.
DR   RefSeq; NP_001038700.1; NM_001045235.1.
DR   AlphaFoldDB; Q1JPS1; -.
DR   SMR; Q1JPS1; -.
DR   STRING; 7955.ENSDARP00000080646; -.
DR   PaxDb; Q1JPS1; -.
DR   Ensembl; ENSDART00000086211; ENSDARP00000080646; ENSDARG00000052388.
DR   GeneID; 692252; -.
DR   KEGG; dre:692252; -.
DR   CTD; 692252; -.
DR   ZFIN; ZDB-GENE-060512-34; pcgf5b.
DR   eggNOG; KOG2660; Eukaryota.
DR   GeneTree; ENSGT00940000155896; -.
DR   HOGENOM; CLU_046427_4_1_1; -.
DR   InParanoid; Q1JPS1; -.
DR   OMA; NRELEFW; -.
DR   OrthoDB; 1203951at2759; -.
DR   PhylomeDB; Q1JPS1; -.
DR   TreeFam; TF324206; -.
DR   Reactome; R-DRE-8939243; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known.
DR   PRO; PR:Q1JPS1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 12.
DR   Bgee; ENSDARG00000052388; Expressed in swim bladder and 25 other tissues.
DR   ExpressionAtlas; Q1JPS1; baseline and differential.
DR   GO; GO:0031519; C:PcG protein complex; ISS:UniProtKB.
DR   GO; GO:0035102; C:PRC1 complex; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0036353; P:histone H2A-K119 monoubiquitination; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR032443; RAWUL.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   Pfam; PF16207; RAWUL; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..232
FT                   /note="Polycomb group RING finger protein 5-B"
FT                   /id="PRO_0000277870"
FT   ZN_FING         18..57
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   REGION          93..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   232 AA;  27248 MW;  BB9BD2467D545861 CRC64;
     MTSHRKHLVR DFNHFITCFV CKGYLIKPTT VTECLHTFCK SCIVQHFEDS NDCPKCGIQV
     HETNPLEMLR LDNTLEEVIF KLVPGLREKE QQQEDEFWRR KESNDENGPM CKKRRVDEED
     DDKGDGDYHR SDPQIAICLD CLRINGQMGE NIVKGLMKKF IRCSTRVTVG TIKKFLSLKL
     KLPSSYELDV LCNGEIMGKD HTMEFIYMTR WRLRGENVYP MVLEYRPRID FG