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PCGF1_XENLA
ID   PCGF1_XENLA             Reviewed;         259 AA.
AC   Q4QR06;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Polycomb group RING finger protein 1;
GN   Name=pcgf1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like
CC       complex, a complex class required to maintain the transcriptionally
CC       repressive state of many genes, including Hox genes, throughout
CC       development. PcG PRC1 complex acts via chromatin remodeling and
CC       modification of histones; it mediates monoubiquitination of histone H2A
CC       'Lys-119', rendering chromatin heritably changed in its expressibility.
CC       {ECO:0000250|UniProtKB:Q9BSM1}.
CC   -!- SUBUNIT: Component of a PRC1-like complex.
CC       {ECO:0000250|UniProtKB:Q9BSM1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BSM1}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH97736.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC097736; AAH97736.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001089498.2; NM_001096029.1.
DR   AlphaFoldDB; Q4QR06; -.
DR   DNASU; 734550; -.
DR   GeneID; 734550; -.
DR   KEGG; xla:734550; -.
DR   CTD; 734550; -.
DR   Xenbase; XB-GENE-6255892; pcgf1.L.
DR   OrthoDB; 1203951at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 734550; Expressed in oocyte and 19 other tissues.
DR   GO; GO:0031519; C:PcG protein complex; ISS:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0036353; P:histone H2A-K119 monoubiquitination; ISS:UniProtKB.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR032443; RAWUL.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   Pfam; PF16207; RAWUL; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..259
FT                   /note="Polycomb group RING finger protein 1"
FT                   /id="PRO_0000277859"
FT   ZN_FING         45..84
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
SQ   SEQUENCE   259 AA;  30128 MW;  0714DFD7035BAB57 CRC64;
     MASQGPLVIA MRLRNQLQSV YKMDPLRNEE VVKVKIKELN EHIVCYLCAG YFIDATTITE
     CLHTFCKSCI VKYLQTSKYC PLCNIKIHET QPLLNLKLDR VMQDIVYKLV PGLQENEDSR
     IRDFYHSRGL ERVLQPSAVE DSVGDVSQLS LSLAVSQKTS HYYRNDEHVC LCLEKVSSGK
     DKKKFILQQK YVRCSVRSEI RHLRRVLSHR LSAPLAQVQL LIDNKVLPDH MTMKQLWLMH
     WYGKPAPLVL LYSVKEKRR
 
 
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