PCGF1_XENTR
ID PCGF1_XENTR Reviewed; 259 AA.
AC Q28H21;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Polycomb group RING finger protein 1;
GN Name=pcgf1; ORFNames=TEgg135k09.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Egg;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like
CC complex, a complex class required to maintain the transcriptionally
CC repressive state of many genes, including Hox genes, throughout
CC development. PcG PRC1 complex acts via chromatin remodeling and
CC modification of histones; it mediates monoubiquitination of histone H2A
CC 'Lys-119', rendering chromatin heritably changed in its expressibility.
CC {ECO:0000250|UniProtKB:Q9BSM1}.
CC -!- SUBUNIT: Component of a PRC1-like complex.
CC {ECO:0000250|UniProtKB:Q9BSM1}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BSM1}.
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DR EMBL; CR761098; CAJ81866.1; -; mRNA.
DR RefSeq; NP_001016417.2; NM_001016417.2.
DR AlphaFoldDB; Q28H21; -.
DR SMR; Q28H21; -.
DR GeneID; 549171; -.
DR KEGG; xtr:549171; -.
DR CTD; 84759; -.
DR Xenbase; XB-GENE-6454077; pcgf1.
DR InParanoid; Q28H21; -.
DR Proteomes; UP000008143; Chromosome 8.
DR Proteomes; UP000790000; Unplaced.
DR GO; GO:0031519; C:PcG protein complex; ISS:UniProtKB.
DR GO; GO:0035102; C:PRC1 complex; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:1990841; F:promoter-specific chromatin binding; IBA:GO_Central.
DR GO; GO:0036353; P:histone H2A-K119 monoubiquitination; ISS:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR032443; RAWUL.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR Pfam; PF16207; RAWUL; 1.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..259
FT /note="Polycomb group RING finger protein 1"
FT /id="PRO_0000277860"
FT ZN_FING 45..84
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
SQ SEQUENCE 259 AA; 30106 MW; A250CA97B5AF8A0E CRC64;
MASQGPLVIA MRLRNQLQSV YKMDPLRNEE VVKVKIKELN EHIVCYLCAG YFIDATTITE
CLHTFCKSCI VKYLQTSKYC PLCNIKIHET QPLLNLKLDR VMQDIVYKLV PGLQENEDGR
IRDFYHSRGL ERVLQPSAVE DSVGDVSQLS LSLAVSQKTS HYYRNDEHVC LCLEKVSSGK
DKKKFILEQK YVRCSVRSEI RHLRRVLSHR LSAPLAHVQL LIDNKVLPDH MTMKQLWLTH
WYGKPAPLVL LYSVREKRR