位置:首页 > 蛋白库 > PCGF1_XENTR
PCGF1_XENTR
ID   PCGF1_XENTR             Reviewed;         259 AA.
AC   Q28H21;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Polycomb group RING finger protein 1;
GN   Name=pcgf1; ORFNames=TEgg135k09.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like
CC       complex, a complex class required to maintain the transcriptionally
CC       repressive state of many genes, including Hox genes, throughout
CC       development. PcG PRC1 complex acts via chromatin remodeling and
CC       modification of histones; it mediates monoubiquitination of histone H2A
CC       'Lys-119', rendering chromatin heritably changed in its expressibility.
CC       {ECO:0000250|UniProtKB:Q9BSM1}.
CC   -!- SUBUNIT: Component of a PRC1-like complex.
CC       {ECO:0000250|UniProtKB:Q9BSM1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BSM1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR761098; CAJ81866.1; -; mRNA.
DR   RefSeq; NP_001016417.2; NM_001016417.2.
DR   AlphaFoldDB; Q28H21; -.
DR   SMR; Q28H21; -.
DR   GeneID; 549171; -.
DR   KEGG; xtr:549171; -.
DR   CTD; 84759; -.
DR   Xenbase; XB-GENE-6454077; pcgf1.
DR   InParanoid; Q28H21; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0031519; C:PcG protein complex; ISS:UniProtKB.
DR   GO; GO:0035102; C:PRC1 complex; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:1990841; F:promoter-specific chromatin binding; IBA:GO_Central.
DR   GO; GO:0036353; P:histone H2A-K119 monoubiquitination; ISS:UniProtKB.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR032443; RAWUL.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   Pfam; PF16207; RAWUL; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..259
FT                   /note="Polycomb group RING finger protein 1"
FT                   /id="PRO_0000277860"
FT   ZN_FING         45..84
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
SQ   SEQUENCE   259 AA;  30106 MW;  A250CA97B5AF8A0E CRC64;
     MASQGPLVIA MRLRNQLQSV YKMDPLRNEE VVKVKIKELN EHIVCYLCAG YFIDATTITE
     CLHTFCKSCI VKYLQTSKYC PLCNIKIHET QPLLNLKLDR VMQDIVYKLV PGLQENEDGR
     IRDFYHSRGL ERVLQPSAVE DSVGDVSQLS LSLAVSQKTS HYYRNDEHVC LCLEKVSSGK
     DKKKFILEQK YVRCSVRSEI RHLRRVLSHR LSAPLAHVQL LIDNKVLPDH MTMKQLWLTH
     WYGKPAPLVL LYSVREKRR
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024