ID   PCGF3_BOVIN             Reviewed;         242 AA.
AC   Q2KJ29;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Polycomb group RING finger protein 3;
GN   Name=PCGF3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like
CC       complex, a complex class required to maintain the transcriptionally
CC       repressive state of many genes, including Hox genes, throughout
CC       development. PcG PRC1 complex acts via chromatin remodeling and
CC       modification of histones; it mediates monoubiquitination of histone H2A
CC       'Lys-119', rendering chromatin heritably changed in its expressibility
CC       (By similarity). Within the PRC1-like complex, regulates RNF2 ubiquitin
CC       ligase activity (By similarity). Plays a redundant role with PCGF5 as
CC       part of a PRC1-like complex that mediates monoubiquitination of histone
CC       H2A 'Lys-119' on the X chromosome and is required for normal silencing
CC       of one copy of the X chromosome in XX females (By similarity).
CC       {ECO:0000250|UniProtKB:Q3KNV8, ECO:0000250|UniProtKB:Q8BTQ0}.
CC   -!- SUBUNIT: Component of a PRC1-like complex that contains PCGF3, RNF2 and
CC       RYBP (By similarity). Interacts with CBX6, CBX7 and CBX8 (By
CC       similarity). Interacts with BCORL1 (By similarity).
CC       {ECO:0000250|UniProtKB:Q3KNV8, ECO:0000250|UniProtKB:Q8BTQ0}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8BTQ0}. Nucleus,
CC       nucleoplasm {ECO:0000250|UniProtKB:Q8BTQ0}. Note=Recruited by the non-
CC       coding RNA Xist to specific nuclear foci that probably correspond to
CC       the inactivated X chromosome. {ECO:0000250|UniProtKB:Q8BTQ0}.
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DR   EMBL; BC105550; AAI05551.1; -; mRNA.
DR   RefSeq; NP_001040032.1; NM_001046567.1.
DR   AlphaFoldDB; Q2KJ29; -.
DR   SMR; Q2KJ29; -.
DR   STRING; 9913.ENSBTAP00000054369; -.
DR   PaxDb; Q2KJ29; -.
DR   PRIDE; Q2KJ29; -.
DR   Ensembl; ENSBTAT00000018621; ENSBTAP00000018621; ENSBTAG00000014017.
DR   Ensembl; ENSBTAT00000067150; ENSBTAP00000063193; ENSBTAG00000014017.
DR   GeneID; 615967; -.
DR   KEGG; bta:615967; -.
DR   CTD; 10336; -.
DR   VEuPathDB; HostDB:ENSBTAG00000014017; -.
DR   VGNC; VGNC:97295; PCGF3.
DR   eggNOG; KOG2660; Eukaryota.
DR   GeneTree; ENSGT00940000158395; -.
DR   InParanoid; Q2KJ29; -.
DR   OMA; ILCNNEL; -.
DR   OrthoDB; 1203951at2759; -.
DR   Proteomes; UP000009136; Chromosome 6.
DR   Bgee; ENSBTAG00000014017; Expressed in ruminant reticulum and 106 other tissues.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0031519; C:PcG protein complex; ISS:UniProtKB.
DR   GO; GO:0035102; C:PRC1 complex; IBA:GO_Central.
DR   GO; GO:0000805; C:X chromosome; IEA:Ensembl.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0036353; P:histone H2A-K119 monoubiquitination; ISS:UniProtKB.
DR   GO; GO:0060819; P:inactivation of X chromosome by genomic imprinting; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR032443; RAWUL.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   Pfam; PF16207; RAWUL; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..242
FT                   /note="Polycomb group RING finger protein 3"
FT                   /id="PRO_0000277863"
FT   ZN_FING         17..56
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   REGION          115..149
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          132..242
FT                   /note="Interaction with BCORL1"
FT                   /evidence="ECO:0000250|UniProtKB:Q3KNV8"
SQ   SEQUENCE   242 AA;  28081 MW;  39C0DD41E9131B41 CRC64;
     MLTRKIKLWD INAHITCRLC SGYLIDATTV TECLHTFCRS CLVKYLEENN TCPTCRIVIH
     QSHPLQYIGH DRTMQDIVYK LVPGLQEAEM RKQREFYHKL GLEVPGDIKG ETCSAKQHLD
     PHRNGETKAD DSSNKEAAEE KQEEDGDYHR SDEQVSICLE CNSSKLRGLK RKWIRCSAQA
     TVLHLKKFIA KKLNLSSFNE LDILCNEEIL GKDHTLKFVV VTRWRFKKAP LLLHYRPKMD
     LL