ID   PCGF3_XENTR             Reviewed;         242 AA.
AC   Q07G17;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Polycomb group RING finger protein 3;
GN   Name=pcgf3; ORFNames=TNeu137d10.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like
CC       complex, a complex class required to maintain the transcriptionally
CC       repressive state of many genes, including Hox genes, throughout
CC       development. PcG PRC1 complex acts via chromatin remodeling and
CC       modification of histones; it mediates monoubiquitination of histone H2A
CC       'Lys-119', rendering chromatin heritably changed in its expressibility.
CC       Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity.
CC       {ECO:0000250|UniProtKB:Q3KNV8}.
CC   -!- SUBUNIT: Component of a PRC1-like complex.
CC       {ECO:0000250|UniProtKB:Q3KNV8}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q3KNV8}.
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DR   EMBL; CR855442; CAL49402.1; -; mRNA.
DR   RefSeq; NP_001016847.1; NM_001016847.1.
DR   AlphaFoldDB; Q07G17; -.
DR   SMR; Q07G17; -.
DR   STRING; 8364.ENSXETP00000010700; -.
DR   GeneID; 549601; -.
DR   KEGG; xtr:549601; -.
DR   CTD; 10336; -.
DR   Xenbase; XB-GENE-987640; pcgf3.
DR   eggNOG; KOG2660; Eukaryota.
DR   InParanoid; Q07G17; -.
DR   OrthoDB; 1203951at2759; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000004916; Expressed in ovary and 12 other tissues.
DR   GO; GO:0031519; C:PcG protein complex; ISS:UniProtKB.
DR   GO; GO:0035102; C:PRC1 complex; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0036353; P:histone H2A-K119 monoubiquitination; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR032443; RAWUL.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   Pfam; PF16207; RAWUL; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..242
FT                   /note="Polycomb group RING finger protein 3"
FT                   /id="PRO_0000277866"
FT   ZN_FING         17..56
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   REGION          120..149
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   242 AA;  28442 MW;  9A8BD52162898F5E CRC64;
     MLTRKIKLWD INAHITCRLC NGYLIDATTV TECLHTFCRS CLVKYLEENN TCPTCRIVIH
     QSHPLQYIGH DRTMQDIVYK LVPGLQEAEM RKQREFYHKL GMEVPGDIKA EILTVKQHVE
     AHRNGETKTD EHTHKEPPEE KQEEDHDYHR SDEQVSICLE CNSSKLRGLK RKWIRCSAQA
     TVLHLKKFIA KKLNLSSFNE LDILCNEEIL GKDHTLKFVV VTRWRFKKAP LLLHYRPKMD
     LL