ID   PCGF5_BOVIN             Reviewed;         255 AA.
AC   A0JN86;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Polycomb group RING finger protein 5;
GN   Name=PCGF5;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like
CC       complex, a complex class required to maintain the transcriptionally
CC       repressive state of many genes, including Hox genes, throughout
CC       development. PcG PRC1 complex acts via chromatin remodeling and
CC       modification of histones; it mediates monoubiquitination of histone H2A
CC       'Lys-119', rendering chromatin heritably changed in its expressibility
CC       (By similarity). Within the PRC1-like complex, regulates RNF2 ubiquitin
CC       ligase activity (By similarity). Plays a redundant role with PCGF3 as
CC       part of a PRC1-like complex that mediates monoubiquitination of histone
CC       H2A 'Lys-119' on the X chromosome and is required for normal silencing
CC       of one copy of the X chromosome in XX females (By similarity).
CC       {ECO:0000250|UniProtKB:Q3UK78, ECO:0000250|UniProtKB:Q86SE9}.
CC   -!- SUBUNIT: Component of a PRC1-like complex that contains PCGF5, RNF2 and
CC       UBE2D3. Interacts with RNF2; the interaction is direct. Interacts with
CC       CBX6, CBX7 and CBX8. Interacts with AUTS2; the interaction is direct.
CC       Identified in a complex that contains AUTS2, PCGF5, CSNK2B and RNF2.
CC       {ECO:0000250|UniProtKB:Q86SE9}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q3UK78}. Nucleus,
CC       nucleoplasm {ECO:0000250|UniProtKB:Q3UK78}. Note=Recruited by the non-
CC       coding RNA Xist to specific nuclear foci that probably correspond to
CC       the inactivated X chromosome. {ECO:0000250|UniProtKB:Q3UK78}.
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DR   EMBL; BC126565; AAI26566.1; -; mRNA.
DR   RefSeq; NP_001071448.1; NM_001077980.1.
DR   AlphaFoldDB; A0JN86; -.
DR   SMR; A0JN86; -.
DR   STRING; 9913.ENSBTAP00000006533; -.
DR   PaxDb; A0JN86; -.
DR   Ensembl; ENSBTAT00000006533; ENSBTAP00000006533; ENSBTAG00000004964.
DR   GeneID; 528946; -.
DR   KEGG; bta:528946; -.
DR   CTD; 84333; -.
DR   VEuPathDB; HostDB:ENSBTAG00000004964; -.
DR   VGNC; VGNC:32628; PCGF5.
DR   eggNOG; KOG2660; Eukaryota.
DR   GeneTree; ENSGT00940000155896; -.
DR   HOGENOM; CLU_046427_4_1_1; -.
DR   InParanoid; A0JN86; -.
DR   OMA; NRELEFW; -.
DR   OrthoDB; 1203951at2759; -.
DR   TreeFam; TF324206; -.
DR   Proteomes; UP000009136; Chromosome 26.
DR   Bgee; ENSBTAG00000004964; Expressed in neutrophil and 108 other tissues.
DR   ExpressionAtlas; A0JN86; baseline.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0031519; C:PcG protein complex; ISS:UniProtKB.
DR   GO; GO:0035102; C:PRC1 complex; IBA:GO_Central.
DR   GO; GO:0000805; C:X chromosome; IEA:Ensembl.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0036353; P:histone H2A-K119 monoubiquitination; ISS:UniProtKB.
DR   GO; GO:0060819; P:inactivation of X chromosome by genomic imprinting; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR032443; RAWUL.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   Pfam; PF16207; RAWUL; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..255
FT                   /note="Polycomb group RING finger protein 5"
FT                   /id="PRO_0000277867"
FT   ZN_FING         18..57
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   REGION          97..132
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   255 AA;  29642 MW;  A2E593366465235E CRC64;
     MATQRKHLVK DFNPYITCYI CKGYLIKPTT VTECLHTFCK TCIVQHFEDS NDCPRCGNQV
     HETNPLEMLR LDNTLEEIIF KLVPGLREQL ERESEFWKKN KPQENGQDDM SKVDKPKVDE
     EGDENQDDKD YHRSDPQIAI CLDCLRNNGQ SGDNVVKGLM KKFIRCSTRV TVGTIKKFLS
     LKLKLPSSYE LDVLCNGEIM GKDHTMEFIY MTRWRLRGEN FRCLNCSASQ VCSQDGPLYQ
     SYPMVLQYRP RIDFG