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PCH2_ARATH
ID   PCH2_ARATH              Reviewed;         467 AA.
AC   Q8H1F9; F4JR10; Q67ZT1; Q9SB66;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Pachytene checkpoint protein 2 homolog {ECO:0000305};
DE            Short=AtPCH2 {ECO:0000303|PubMed:26182244};
GN   Name=PCH2 {ECO:0000303|PubMed:26182244}; OrderedLocusNames=At4g24710;
GN   ORFNames=F22K18.90;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617198; DOI=10.1038/47134;
RA   Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA   Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA   Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA   de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA   Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA   Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA   Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA   Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA   Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA   Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA   Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA   Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA   Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA   Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA   Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA   Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA   Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA   Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA   Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA   Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA   Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA   Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA   Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA   Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA   Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA   Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA   de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA   Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA   Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA   Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA   Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA   Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA   Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA   Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA   Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA   Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA   O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA   Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA   Martienssen R., McCombie W.R.;
RT   "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL   Nature 402:769-777(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 105-467.
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RX   PubMed=26182244; DOI=10.1371/journal.pgen.1005372;
RA   Lambing C., Osman K., Nuntasoontorn K., West A., Higgins J.D.,
RA   Copenhaver G.P., Yang J., Armstrong S.J., Mechtler K., Roitinger E.,
RA   Franklin F.C.;
RT   "Arabidopsis PCH2 mediates meiotic chromosome remodeling and maturation of
RT   crossovers.";
RL   PLoS Genet. 11:E1005372-E1005372(2015).
CC   -!- FUNCTION: Plays a key role in chromosome recombination during meiosis.
CC       Mediates meiotic chromosome remodeling and crossover maturation.
CC       {ECO:0000269|PubMed:26182244}.
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:26182244}.
CC       Note=Localizes to the sites of chromosome axis remodeling.
CC       {ECO:0000269|PubMed:26182244}.
CC   -!- DISRUPTION PHENOTYPE: Reduced fertility. Reduced number of seeds.
CC       {ECO:0000269|PubMed:26182244}.
CC   -!- SIMILARITY: Belongs to the AAA ATPase family. PCH2 subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA22992.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=CAB79381.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AL035356; CAA22992.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AL161562; CAB79381.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002687; AEE84945.2; -; Genomic_DNA.
DR   EMBL; AY150398; AAN12943.1; -; mRNA.
DR   EMBL; AK176036; BAD43799.1; -; mRNA.
DR   PIR; T05563; T05563.
DR   RefSeq; NP_001320058.1; NM_001341695.1.
DR   AlphaFoldDB; Q8H1F9; -.
DR   SMR; Q8H1F9; -.
DR   BioGRID; 13862; 1.
DR   IntAct; Q8H1F9; 2.
DR   STRING; 3702.AT4G24710.1; -.
DR   PaxDb; Q8H1F9; -.
DR   EnsemblPlants; AT4G24710.1; AT4G24710.1; AT4G24710.
DR   GeneID; 828573; -.
DR   Gramene; AT4G24710.1; AT4G24710.1; AT4G24710.
DR   KEGG; ath:AT4G24710; -.
DR   Araport; AT4G24710; -.
DR   eggNOG; KOG0744; Eukaryota.
DR   HOGENOM; CLU_028208_0_1_1; -.
DR   InParanoid; Q8H1F9; -.
DR   OMA; VQIHVEV; -.
DR   PhylomeDB; Q8H1F9; -.
DR   PRO; PR:Q8H1F9; -.
DR   Proteomes; UP000006548; Chromosome 4.
DR   ExpressionAtlas; Q8H1F9; baseline and differential.
DR   Genevisible; Q8H1F9; AT.
DR   GO; GO:0005694; C:chromosome; IDA:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0007129; P:homologous chromosome pairing at meiosis; IMP:UniProtKB.
DR   GO; GO:0051598; P:meiotic recombination checkpoint signaling; IBA:GO_Central.
DR   GO; GO:0007131; P:reciprocal meiotic recombination; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR003960; ATPase_AAA_CS.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR044539; Pch2-like.
DR   PANTHER; PTHR45991; PTHR45991; 1.
DR   Pfam; PF00004; AAA; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00674; AAA; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Chromosome; Meiosis; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..467
FT                   /note="Pachytene checkpoint protein 2 homolog"
FT                   /id="PRO_0000410926"
FT   BINDING         209..216
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   467 AA;  51704 MW;  AA17A444DCCF0F62 CRC64;
     MVEDPIPLPN ASMEVSYQNP IEAATIPVQI AVAEPVATPN PPPCLHENKF LVSVEVCLKP
     SSTARLEDVQ RAVERMLENR SMSYADGLVL IPADDLFLVD NVQRICICDT EEWVKNNDVL
     LFWQVKPVVH TFQLIEEGPC EDLCADGQPA SFNEWILPAK EFDGLWESLI YESGLKQRLL
     RYAASALLFT QKGVNPNLVS WNRIILLHGP PGTGKTSLCK ALAQKLSIRC NSRYPHCQLI
     EVNAHSLFSK WFSESGKLVA KLFQKIQEMV EEDGNLVFVL IDEVESLAAA RKAALSGSEP
     SDSIRVVNAL LTQMDKLKSA PNVIILTTSN ITTAIDVAFV DRADIKAYVG PPTLHVRYEI
     LRSCVEELIS KGIISSFQGC DGLSIPSFSS LKEKLSESEV HDTNTVPWFC KQLIEAAKGC
     EGLSGRSLRK LPFLAHAALA DPYSHDPSNF LCTMIETAKR EKSEQPE
 
 
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