ID   PCH2_CHICK              Reviewed;         432 AA.
AC   E1C6Q1;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2010, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Pachytene checkpoint protein 2 homolog;
DE   AltName: Full=Thyroid hormone receptor interactor 13 homolog;
DE   AltName: Full=Thyroid receptor-interacting protein 13 homolog;
DE            Short=TR-interacting protein 13 homolog;
DE            Short=TRIP-13 homolog;
GN   Name=TRIP13; Synonyms=PCH2;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Red jungle fowl;
RX   PubMed=15592404; DOI=10.1038/nature03154;
RA   Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P.,
RA   Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B.,
RA   Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C.,
RA   Fulton R.S., Graves T.A., Kremitzki C., Layman D., Magrini V.,
RA   McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O.,
RA   Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W.,
RA   Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D.,
RA   Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K.,
RA   Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L.,
RA   Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B.,
RA   Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M.,
RA   Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA   Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA   Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA   Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M.,
RA   Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S.,
RA   Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M.,
RA   Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M.,
RA   Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A.,
RA   Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S.,
RA   Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J.,
RA   Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J.,
RA   Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E.,
RA   Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M.,
RA   Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A.,
RA   Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA   Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA   Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E.,
RA   Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S.,
RA   Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E.,
RA   Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R.,
RA   Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R.,
RA   Wilson R.K.;
RT   "Sequence and comparative analysis of the chicken genome provide unique
RT   perspectives on vertebrate evolution.";
RL   Nature 432:695-716(2004).
CC   -!- FUNCTION: Plays a key role in chromosome recombination and chromosome
CC       structure development during meiosis. Required at early steps in
CC       meiotic recombination that leads to non-crossovers pathways. Also
CC       needed for efficient completion of homologous synapsis by influencing
CC       crossover distribution along the chromosomes affecting both crossovers
CC       and non-crossovers pathways (By similarity).
CC       {ECO:0000250|UniProtKB:Q3UA06}.
CC   -!- SIMILARITY: Belongs to the AAA ATPase family. PCH2 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AADN02027348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001291984.1; NM_001305055.1.
DR   RefSeq; NP_001291985.1; NM_001305056.1.
DR   AlphaFoldDB; E1C6Q1; -.
DR   SMR; E1C6Q1; -.
DR   STRING; 9031.ENSGALP00000020406; -.
DR   PaxDb; E1C6Q1; -.
DR   Ensembl; ENSGALT00000090074; ENSGALP00000064487; ENSGALG00000033834.
DR   GeneID; 420798; -.
DR   KEGG; gga:420798; -.
DR   CTD; 9319; -.
DR   VEuPathDB; HostDB:geneid_420798; -.
DR   eggNOG; KOG0744; Eukaryota.
DR   GeneTree; ENSGT00390000017432; -.
DR   HOGENOM; CLU_028208_0_1_1; -.
DR   InParanoid; E1C6Q1; -.
DR   OMA; VQIHVEV; -.
DR   OrthoDB; 1036414at2759; -.
DR   PhylomeDB; E1C6Q1; -.
DR   TreeFam; TF313507; -.
DR   PRO; PR:E1C6Q1; -.
DR   Proteomes; UP000000539; Chromosome 2.
DR   Bgee; ENSGALG00000033834; Expressed in spermatid and 11 other tissues.
DR   GO; GO:0005694; C:chromosome; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0006302; P:double-strand break repair; ISS:UniProtKB.
DR   GO; GO:0051598; P:meiotic recombination checkpoint signaling; IBA:GO_Central.
DR   GO; GO:0048477; P:oogenesis; ISS:UniProtKB.
DR   GO; GO:0007131; P:reciprocal meiotic recombination; ISS:UniProtKB.
DR   GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR   GO; GO:0007130; P:synaptonemal complex assembly; ISS:UniProtKB.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR003960; ATPase_AAA_CS.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR044539; Pch2-like.
DR   PANTHER; PTHR45991; PTHR45991; 1.
DR   Pfam; PF00004; AAA; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00674; AAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Differentiation; Meiosis; Nucleotide-binding; Oogenesis;
KW   Reference proteome; Spermatogenesis.
FT   CHAIN           1..432
FT                   /note="Pachytene checkpoint protein 2 homolog"
FT                   /id="PRO_0000410923"
FT   BINDING         179..186
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   432 AA;  49079 MW;  49AFABF13FFFDD80 CRC64;
     MDEAAGDLKQ ALPNTCDNVQ IHVEVHQKSN STAKKEDIRM SVLKLLNRHN IVFGDYKWTE
     FDDGFLNSNV QSVSIVDTEL KLKERQPIDL SKSSLTIHIF HLNEEGPSIE NLEEENEDIV
     AANHWVLPAA EFHGLWESLI YDTEVKSHLL DYVTTTLLFS DRNVDSNLIS WNRVVLLHGP
     PGTGKTSLCK ALAQKLTIRL SYRYRYGQLI EINSHSLFSK WFSESGKLVT KMFQKIQELI
     DDKDALVFVL IDEVESLTAA RSAFKAGTEP SDAIRVVNAV LMQIDQIKRY PNVVILTTSN
     ITEKIDMAFV DRADIKQYIG PPSAAAIFRI YLSCLEELMK CQIIYPRQHL LSLRELEMIG
     FVENNVSRLS LVLKEISRRS EGLSGRVLRK LPFLAHALYI QSPSVTMTAF LQALSLVVDK
     QFEERKKLAD CV