ID   PCH2_DANRE              Reviewed;         424 AA.
AC   Q6PH52;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Pachytene checkpoint protein 2 homolog;
DE   AltName: Full=Thyroid hormone receptor interactor 13 homolog;
DE   AltName: Full=Thyroid receptor-interacting protein 13 homolog;
DE            Short=TR-interacting protein 13 homolog;
DE            Short=TRIP-13 homolog;
GN   Name=trip13; Synonyms=pch2; ORFNames=zgc:65952;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a key role in chromosome recombination and chromosome
CC       structure development during meiosis. Required at early steps in
CC       meiotic recombination that leads to non-crossovers pathways. Also
CC       needed for efficient completion of homologous synapsis by influencing
CC       crossover distribution along the chromosomes affecting both crossovers
CC       and non-crossovers pathways (By similarity).
CC       {ECO:0000250|UniProtKB:Q3UA06}.
CC   -!- SIMILARITY: Belongs to the AAA ATPase family. PCH2 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC056713; AAH56713.1; -; mRNA.
DR   RefSeq; NP_956876.1; NM_200582.1.
DR   AlphaFoldDB; Q6PH52; -.
DR   SMR; Q6PH52; -.
DR   IntAct; Q6PH52; 1.
DR   MINT; Q6PH52; -.
DR   STRING; 7955.ENSDARP00000049098; -.
DR   PaxDb; Q6PH52; -.
DR   GeneID; 393554; -.
DR   KEGG; dre:393554; -.
DR   CTD; 9319; -.
DR   ZFIN; ZDB-GENE-040426-1488; trip13.
DR   eggNOG; KOG0744; Eukaryota.
DR   InParanoid; Q6PH52; -.
DR   PhylomeDB; Q6PH52; -.
DR   PRO; PR:Q6PH52; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005694; C:chromosome; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0006302; P:double-strand break repair; ISS:UniProtKB.
DR   GO; GO:0051598; P:meiotic recombination checkpoint signaling; IBA:GO_Central.
DR   GO; GO:0048477; P:oogenesis; ISS:UniProtKB.
DR   GO; GO:0007131; P:reciprocal meiotic recombination; ISS:UniProtKB.
DR   GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR   GO; GO:0007130; P:synaptonemal complex assembly; ISS:UniProtKB.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR003960; ATPase_AAA_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR044539; Pch2-like.
DR   PANTHER; PTHR45991; PTHR45991; 1.
DR   Pfam; PF00004; AAA; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00674; AAA; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Differentiation; Meiosis; Nucleotide-binding; Oogenesis;
KW   Reference proteome; Spermatogenesis.
FT   CHAIN           1..424
FT                   /note="Pachytene checkpoint protein 2 homolog"
FT                   /id="PRO_0000410924"
FT   BINDING         171..178
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   424 AA;  47777 MW;  539260356B839DE4 CRC64;
     MDISDHHMTD VGIIRPDVHI EVHVKSQSTA KRSDVRTHVL SLLDRHSTVL RSFKWMDFDN
     EFLTKNVESV TIADVTGPKL VDLKVHNLCI HIFTLNDDSP STLNLEEEEE LSAANLWLLP
     AVEFHGVWES LIYEEGIKTQ LLDYVSTTIF FSDKNVDSNL IAWNRVVLLH GPPGTGKTSL
     CKGLAQKLSI RLSDRYAHSQ FVEINSHSLF SKWFSESGKL VTKMFQKIQE LIDDKDALVF
     VLIDEVESLT AARSAAQAGT EPSDAIRVVN SVLTQLDQIK RHPNVVILTT SNVTEKIDLA
     FVDRADIKQY IGPPSAKAIF NIYLSSLEEL MKRQIIYPRQ QLVSLEELET MNFMESDVTR
     LSLCLMNISQ RSVGLSGRAL RKIPFLAHAL YGKTSTMTLK GFLTAMEHAV NKQRQEQASL
     VNCV