ID   PCH2_XENTR              Reviewed;         432 AA.
AC   Q6P4W8;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Pachytene checkpoint protein 2 homolog;
DE   AltName: Full=Thyroid hormone receptor interactor 13 homolog;
DE   AltName: Full=Thyroid receptor-interacting protein 13 homolog;
DE            Short=TR-interacting protein 13 homolog;
DE            Short=TRIP-13 homolog;
GN   Name=trip13; Synonyms=pch2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a key role in chromosome recombination and chromosome
CC       structure development during meiosis. Required at early steps in
CC       meiotic recombination that leads to non-crossovers pathways. Also
CC       needed for efficient completion of homologous synapsis by influencing
CC       crossover distribution along the chromosomes affecting both crossovers
CC       and non-crossovers pathways (By similarity).
CC       {ECO:0000250|UniProtKB:Q3UA06}.
CC   -!- SIMILARITY: Belongs to the AAA ATPase family. PCH2 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC063217; AAH63217.1; -; mRNA.
DR   RefSeq; NP_989228.1; NM_203897.1.
DR   RefSeq; XP_012819903.1; XM_012964449.2.
DR   RefSeq; XP_012819905.1; XM_012964451.2.
DR   RefSeq; XP_012819906.1; XM_012964452.2.
DR   AlphaFoldDB; Q6P4W8; -.
DR   SMR; Q6P4W8; -.
DR   PaxDb; Q6P4W8; -.
DR   GeneID; 394836; -.
DR   KEGG; xtr:394836; -.
DR   CTD; 9319; -.
DR   Xenbase; XB-GENE-974898; trip13.
DR   eggNOG; KOG0744; Eukaryota.
DR   HOGENOM; CLU_028208_0_1_1; -.
DR   InParanoid; Q6P4W8; -.
DR   OMA; WEGLWES; -.
DR   OrthoDB; 1036414at2759; -.
DR   TreeFam; TF313507; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   ExpressionAtlas; Q6P4W8; baseline.
DR   GO; GO:0005694; C:chromosome; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0006302; P:double-strand break repair; ISS:UniProtKB.
DR   GO; GO:0051598; P:meiotic recombination checkpoint signaling; IBA:GO_Central.
DR   GO; GO:0048477; P:oogenesis; ISS:UniProtKB.
DR   GO; GO:0007131; P:reciprocal meiotic recombination; ISS:UniProtKB.
DR   GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR   GO; GO:0007130; P:synaptonemal complex assembly; ISS:UniProtKB.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR003960; ATPase_AAA_CS.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR044539; Pch2-like.
DR   PANTHER; PTHR45991; PTHR45991; 1.
DR   Pfam; PF00004; AAA; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00674; AAA; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Differentiation; Meiosis; Nucleotide-binding; Oogenesis;
KW   Reference proteome; Spermatogenesis.
FT   CHAIN           1..432
FT                   /note="Pachytene checkpoint protein 2 homolog"
FT                   /id="PRO_0000410925"
FT   BINDING         179..186
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   432 AA;  49243 MW;  078622288A52D855 CRC64;
     MDEVAVDLKQ ALPNVYNNLQ VHVDVHQKSN SPATSQDIQS HVMQLLNRHC VVFGDYSWTE
     FDDSFLMKNI HSISIADTEL KLKDRQPIDL SKCKVLIHIF QLNEDGPCVE SLEEENEDLV
     AANHWLLPAA DFHGLWDSLI YDSEIKSRLL DYIETAMLFS DKNVDSNLIS WNRVVLLHGP
     PGTGKTSLCK ALAQKLTIRL SYRYRYGQLV EINSHSLFSK WFSESGKLVT KMFQKIHELI
     NDKEALVFVL IDEVESLTAA RKASRAGTEP SDAIRVVNAV LTQIDHIKRY PNVVILSTSN
     LTEKIDVAFT DRADIKQYIG PPSPAAIFKI YLSCIEELMK CQIIYPKQQL LTLRDLEIIG
     FLENNISKLS LQLNEISRKS EGLSGRVLRK LPFLAHALYL QSPTVTIERF LWALSLAVDE
     QFQERKNFSE NI