ID   PCHA_PSEAE              Reviewed;         476 AA.
AC   Q51508;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Salicylate biosynthesis isochorismate synthase;
DE            EC=5.4.4.2;
DE   AltName: Full=Isochorismate mutase;
GN   Name=pchA; OrderedLocusNames=PA4231;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND CHARACTERIZATION.
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=7500944; DOI=10.1007/bf00290369;
RA   Serino L., Reimmann C., Baur H., Beyeler M., Visca P., Haas D.;
RT   "Structural genes for salicylate biosynthesis from chorismate in
RT   Pseudomonas aeruginosa.";
RL   Mol. Gen. Genet. 249:217-228(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: Involved in the conversion of chorismate to salicylate.
CC       {ECO:0000269|PubMed:7500944}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=chorismate = isochorismate; Xref=Rhea:RHEA:18985,
CC         ChEBI:CHEBI:29748, ChEBI:CHEBI:29780; EC=5.4.4.2;
CC   -!- PATHWAY: Siderophore biosynthesis; salicylate biosynthesis.
CC   -!- SIMILARITY: Belongs to the isochorismate synthase family.
CC       {ECO:0000305}.
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DR   EMBL; X82644; CAA57969.1; -; Genomic_DNA.
DR   EMBL; AE004091; AAG07619.1; -; Genomic_DNA.
DR   PIR; S60203; S58229.
DR   RefSeq; NP_252921.1; NC_002516.2.
DR   RefSeq; WP_003114686.1; NZ_QZGE01000028.1.
DR   AlphaFoldDB; Q51508; -.
DR   SMR; Q51508; -.
DR   STRING; 287.DR97_3680; -.
DR   PaxDb; Q51508; -.
DR   PRIDE; Q51508; -.
DR   EnsemblBacteria; AAG07619; AAG07619; PA4231.
DR   GeneID; 881821; -.
DR   KEGG; pae:PA4231; -.
DR   PATRIC; fig|208964.12.peg.4432; -.
DR   PseudoCAP; PA4231; -.
DR   HOGENOM; CLU_006493_8_4_6; -.
DR   InParanoid; Q51508; -.
DR   OMA; TGHGQSI; -.
DR   PhylomeDB; Q51508; -.
DR   BioCyc; MetaCyc:MON-15306; -.
DR   BioCyc; PAER208964:G1FZ6-4304-MON; -.
DR   BRENDA; 5.4.4.2; 5087.
DR   UniPathway; UPA00025; -.
DR   PHI-base; PHI:5057; -.
DR   PHI-base; PHI:6988; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0008909; F:isochorismate synthase activity; IDA:PseudoCAP.
DR   GO; GO:0042864; P:pyochelin biosynthetic process; IDA:CACAO.
DR   GO; GO:0009697; P:salicylic acid biosynthetic process; IDA:PseudoCAP.
DR   Gene3D; 3.60.120.10; -; 1.
DR   InterPro; IPR005801; ADC_synthase.
DR   InterPro; IPR015890; Chorismate_C.
DR   InterPro; IPR004561; IsoChor_synthase.
DR   Pfam; PF00425; Chorismate_bind; 1.
DR   SUPFAM; SSF56322; SSF56322; 1.
DR   TIGRFAMs; TIGR00543; isochor_syn; 1.
PE   1: Evidence at protein level;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..476
FT                   /note="Salicylate biosynthesis isochorismate synthase"
FT                   /id="PRO_0000154151"
FT   REGION          181..202
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   476 AA;  52071 MW;  D0F6AFD9CDCF9CF5 CRC64;
     MSRLAPLSQC LHALRGTFER AIGQAQALDR PVLVAASFEI DPLDPLQVFG AWDDRQTPCL
     YWEQPELAFF AWGCALELQG HGEQRFARIE ENWQLLCADA VVEGPLAPRL CGGFRFDPRG
     PREEHWQAFA DASLMLAGIT VLREGERYRV LCQHLAKPGE DALALAAYHC SALLRLRQPA
     RRRPSGPTAG AQGDASAQER RQWEAKVSDA VSSVRQGRFG KVVLARTQAR PLGDIEPWQV
     IEHLRLQHAD AQLFACRRGN ACFLGASPER LVRIRAGEAL THALAGTIAR GGDAQEDARL
     GQALLDSAKD RHEHQLVVEA IRTALEPFSE VLEIPDAPGL KRLARVQHLN TPIRARLADA
     GGILRLLQAL HPTPAVGGYP RSAALDYIRQ HEGMDRGWYA APLGWLDGEG NGDFLVALRS
     ALLTPGRGYL FAGCGLVGDS EPAHEYRETC LKLSAMREAL SAIGGLDEVP LQRGVA