ID   PCHR_PSEAE              Reviewed;         296 AA.
AC   P40883;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Regulatory protein PchR;
GN   Name=pchR; OrderedLocusNames=PA4227;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=8397186; DOI=10.1128/jb.175.18.5882-5889.1993;
RA   Heinrichs D.E., Poole K.;
RT   "Cloning and sequence analysis of a gene (pchR) encoding an AraC family
RT   activator of pyochelin and ferripyochelin receptor synthesis in Pseudomonas
RT   aeruginosa.";
RL   J. Bacteriol. 175:5882-5889(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: Positive activator of the genes for pyochelin and
CC       ferripyochelin receptors.
CC   -!- INDUCTION: Expression is iron regulated.
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DR   EMBL; L11657; AAA25926.1; -; Genomic_DNA.
DR   EMBL; AE004091; AAG07615.1; -; Genomic_DNA.
DR   PIR; A48496; A48496.
DR   RefSeq; NP_252917.1; NC_002516.2.
DR   RefSeq; WP_003106955.1; NZ_QZGE01000028.1.
DR   AlphaFoldDB; P40883; -.
DR   SMR; P40883; -.
DR   STRING; 287.DR97_3684; -.
DR   PaxDb; P40883; -.
DR   PRIDE; P40883; -.
DR   DNASU; 880049; -.
DR   EnsemblBacteria; AAG07615; AAG07615; PA4227.
DR   GeneID; 880049; -.
DR   KEGG; pae:PA4227; -.
DR   PATRIC; fig|208964.12.peg.4428; -.
DR   PseudoCAP; PA4227; -.
DR   HOGENOM; CLU_052345_4_2_6; -.
DR   InParanoid; P40883; -.
DR   OMA; YEEPLER; -.
DR   PhylomeDB; P40883; -.
DR   BioCyc; PAER208964:G1FZ6-4300-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   CollecTF; EXPREG_00000aa0; -.
DR   GO; GO:0032993; C:protein-DNA complex; IMP:CollecTF.
DR   GO; GO:0001216; F:DNA-binding transcription activator activity; IMP:CollecTF.
DR   GO; GO:0001217; F:DNA-binding transcription repressor activity; IMP:CollecTF.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IMP:CollecTF.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   Pfam; PF12833; HTH_18; 1.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..296
FT                   /note="Regulatory protein PchR"
FT                   /id="PRO_0000194544"
FT   DOMAIN          201..296
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        218..239
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        266..288
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ   SEQUENCE   296 AA;  32339 MW;  6EF141CF852D7D84 CRC64;
     MTITIIAPPQ ADAAAPAPGN RPGVAHIDPN MKLVTGTFCS ASEDWFEEPL ERGLRLILVQ
     SGQLRCRIPG QPEHLIEGPS LCTIANDGDF TSAQIYGTDK PLRYTIVQLG VEALDSRLGW
     LPEQLIRRPG GDPRIMSCPA PRAMQALASQ IATCQMLGPT RDLYLGGKAL ELAALSAQFL
     SGEGRPVEEP RITCSEVERI HAARDLLVGA LQEPPSLDTL ASRVGMNPRK LTAGFRKVFG
     ASVFGYLQEY RLREAHRMLC DEEANVSTVA YRVGYSPAHF SIAFRKRYGI SPSEIR